Results 41 to 50 of about 12,620 (174)

Synthesis of ketoprofen - L- phenylalanine and Ketoprofen -y- Aminobutyric acid ethyl esters as possible prodrugs [PDF]

المجلة العراقية للصيدلة, 2006
Ethyl ester HCI of the amino acids -L- phenylalanine and 7- Aminobutyric acid were synthesized through reaction of these amino acids with thionyl chloride in absolute ethanol.
Muthanna D.Saud, Fuad H. Al-Jawad, Adheed K. Sharrad   +2 more
doaj   +1 more source

Recent progress on the development of hydrogel‐based microneedles for transdermal drug delivery

VIEW, EarlyView.
This study provides a comprehensive and up‐to‐date analysis of recent progress in HMN technology, covering fundamental transdermal delivery mechanisms and design principles, biomaterials used in HMN fabrication, drug loading and release strategies, and emerging therapeutic applications.
Mohammad Muhtasim Ittisaf, Salman Farsi Taharat, Md. Sadek Miah, Hasan Tasnim Salehin, M. Azam Ali, Shoeb Ahmed   +5 more
wiley   +1 more source

Formulation and In Vitro Evaluation of Matrix Tablets Containing Ketoprofen–Beta Cyclodextrin Complex for Enhanced Rheumatoid Arthritis Therapy: Experimental and Computational Insights

Pharmaceutics
Background: Rheumatoid arthritis is a chronic autoimmune disease that leads to severe disability and requires improved therapeutic strategies to optimize anti-inflammatory treatment.
Monica Stamate Cretan, Lacramioara Ochiuz, Vlad Ghizdovat, Monica Molcalut, Maricel Agop, Carmen Anatolia Gafițanu, Alexandra Barsan (Bujor), Mousa Sha’at, Ciprian Stamate   +8 more
doaj   +1 more source

Application of innovative strategy in the characterization of ketoprofen gels authorized in the Republic of Serbia [PDF]

Hospital Pharmacology
Introduction: Topical ketoprofen formulations provide localized analgesic and anti-inflammatory effects while reducing systemic adverse events associated with oral administration.
Ćoškov Aleksandra D., Todorović Nemanja B., Arapović Katarina D., Bojić Ana B., Čanji-Panić Jelena M., Vuković Milana M., Lalić-Popović Mladena N.   +6 more
doaj   +1 more source

Four‐dimensional immuno‐mechanobiomaterials: Dynamic material cues that program host response to prevent fibrosis and enable regeneration

VIEW, EarlyView.
Dynamic immuno‐mechanobiomaterials with time‐programmed mechanical adaptation orchestrate host responses through precise mechanotransduction and immune‐stromal regulation. These adaptive biomaterials minimize mechanical mismatch, attenuate the forign dy response and fibrosis, promote angiogenesis and controlled extracellular matrix remodeling, and ...
Gobinath Vellapalayam Manoharan, Kathirvel Ayyaswamy, Parthasarathy Vellaichamy, Nagarajan Deivanayagam Pillai, Rithik Gobinath   +4 more
wiley   +1 more source

Ketoprofen-Tromethamine: Binary Phase Diagram of Multicomponent Crystal, Dissolution Rate, and Analgesic Activity Evaluation

Science and Technology Indonesia
Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) whose formulation options are limited due to its low dissolution rate in aqueous media. This research aimed to enhance the solubility of ketoprofen in distilled water and to compare the anti ...
Uswatul Hasanah, Elsa Badriyya, Reza Safitri, Sukma Yuliza, Ikhwanul Ihsan, Saafrida, Henni Rosaini, Adhitya Jessica, Erizal Zaini   +8 more
doaj   +1 more source

Updated EAACI Statement on Drug Hypersensitivity Skin Testing: Methodology and Non‐Irritative Concentrations

Allergy, EarlyView.
ABSTRACT These updated EAACI guidelines aim to standardize skin testing methodologies for both immediate and non‐immediate drug hypersensitivity reactions. For immediate reactions, the optimal testing window is 4–6 weeks post‐reaction; whereas beyond 6 months, false‐negative results increase.
Annick Barbaud, Lene Heise Garvey, Elizabeth Phillips, Michael Ardern‐Jones, Sevim Bavbek, Patrizia Bonadonna, Jean‐Christoph Caubet, Ana‐Maria Copaescu, Valentina Gueli, Jose Julio Laguna, Ricardo Madrigal‐Burgaleta, Francesca Mori, Vito Sabato, Maria J Torres, Knut Brockow   +14 more
wiley   +1 more source

Experimental and Statistical Studies in the Development of Ketoprofen–Hydroxypropyl-β-Cyclodextrin Inclusion Complexes for Application in Compressed Tablets

Macromol
Ketoprofen is a Biopharmaceutics Classification System (BCS) class II non-steroidal anti-inflammatory drug whose therapeutic performance is limited by its poor aqueous solubility, though complexation with cyclodextrins is a well-established strategy to ...
Monica Stamate Cretan, Lacramioara Ochiuz, Camelia-Elena Iurciuc-Tincu, Carmen Anatolia Gafițanu, Alexandra Barsan (Bujor), Mousa Sha’at, Ciprian Stamate   +6 more
doaj   +1 more source

The Impact of Common Medications on Male Fertility: An Updated Systematic Review

Andrology, EarlyView.
ABSTRACT Background Compared with those of cytotoxic treatments, the potential effects of common medications on the fertility of men trying to conceive currently or planning to conceive in the future are less well described. The use of common medications may modify the gonadotropic axis, spermatogenesis, and epididymal maturation or alter male ...
Lina Jebli, Salomé Gallissian, Roxanne Barèges, Félicia Fournier, Catherine Metzler‐Guillemain, Ségolène Prades, Fanny Magnan‐Sebag, Jeanne Perrin   +7 more
wiley   +1 more source

Molecular Mobility of Different Forms of Ketoprofen Based on DFT Calculation Data

Chemistry Proceedings
Ketoprofen is a representative of the group of non-steroidal anti-inflammatory drugs widely used in modern medical therapy. The intramolecular dynamics of ketoprofen are of particular importance, since the mobility of its main structural fragments is one
Kapitolina A. Logacheva, Alexander V. Belushkin, Polina A. Gergelezhiu, Alexander B. Eresko, Sergey N. Malakhov, Elena V. Raksha, Ludmila I. Savostina, Dorota M. Chudoba   +7 more
doaj   +1 more source