British Journal of Pharmacology, EarlyView.Background The activity of CYP2C9, an important drug metabolism enzyme, is subject to the impact of genetic polymorphism. The single nucleotide polymorphism *3 is significantly associated with the increased exposure of CYP2C9 substrates. In addition, metabolic enzyme inhibitors such as fluconazole may also increase the drug exposure of CYP2C9 ...
Shen Cheng +5 more
wiley +1 more source
Probing skin photoallergens in reconstructed human epidermis: An EPR spin trapping investigation
Photochemistry and Photobiology, Volume 101, Issue 2, Page 275-281, March/April 2025.We present an original proof‐of‐concept methodology to probe radical generation from allergens in contact with photoexposed skin, using electron paramagnetic resonance and spin trapping in a reconstructed human epidermis model mimicking real‐life exposure scenarios.
Yannick Port‐Lougarre +3 more
wiley +1 more source
Ketoprofen Comparative Pharmacokinetics Analysis in Humans and Animals: A Review
Безопасность и риск фармакотерапииINTRODUCTION. Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) with pronounced analgesic, anti-inflammatory and antipyretic effect. Ketoprofen pharmacokinetics is comparatively well described in various in vivo models. Since it is potentially
E. M. Petrova +4 more
doaj +1 more source
Formulation, optimization and evaluation of sustained release microsphere of ketoprofen
Journal of Pharmacy and Bioallied Sciences, 2012 The objective of this study is to formulate ketoprofen loaded microspheres of Acrycoat S100 by an o/w emulsion solvent evaporation method. It potently inhibits the enzyme cyclooxygenase resulting in prostaglandin synthesis inhibition.
V Chirag Prajapati +2 more
doaj +1 more source
Analgesic effects of platelet‐rich fibrin (PRF): A systematic review
Periodontology 2000, EarlyView.Abstract Background Platelet‐rich fibrin (PRF), a second‐generation autologous platelet concentrate, has gained significant interest for its anti‐inflammatory and regenerative characteristics. While its role in tissue healing is well‐recognized, the analgesic potential of PRF remains under‐investigated.
Nathan E. Estrin +6 more
wiley +1 more source
Evaluation of the neurotoxic effects of intrathecal administration of (S)-(+)-Ketoprofen on rat spinal cords: randomized controlled experimental study [PDF]
Revista Brasileira de Anestesiologia, 2019 Background and objectives Intrathecal administration of non-steroidal anti-inflammatory drugs is more efficacious for post-operative pain management.
Cengiz Kaya +5 more
doaj +3 more sources
In vitro and in vivo studies of artichoke extract (Cynara scolymus L.) as ketoprofen skin penetration enhancer [PDF]
, 2006 In this study, the enhancing effect of artichoke extract containing cynaropicrin on the in vitro and in vivo percutaneous absorption of ketoprofen from gels has been ...
Alamanni, Maria Cristina Paolina +6 more
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Protective effect of snail secretion filtrate in an in vitro model of mastitis
Veterinary Record Open, Volume 13, Issue 1, June 2026.Abstract Background Bovine mastitis is inflammation of the mammary gland mainly caused by bacterial infections, with relevant economic costs and implications related to antibiotic resistance. In light of the increasing demand for sustainable therapies, this study evaluated the anti‐inflammatory and antioxidant effects of snail secretion filtrate (SSF ...
Gianluca Antonio Franco +5 more
wiley +1 more source
Meloxicam decreases the migration and invasion of CF41.Mg canine mammary carcinoma cells [PDF]
, 2017 Indexación: Web of Science; Scopus.Cyclooxygenase (COX)-2 expression is positively correlated with malignant features in canine mammary carcinomas. Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit COX activity and may therefore possess anticancer ...
Arias, J.I. +3 more
core +1 more source