Results 61 to 70 of about 34,264 (258)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Molecular Mobility of Different Forms of Ketoprofen Based on DFT Calculation Data

Chemistry Proceedings
Ketoprofen is a representative of the group of non-steroidal anti-inflammatory drugs widely used in modern medical therapy. The intramolecular dynamics of ketoprofen are of particular importance, since the mobility of its main structural fragments is one
Kapitolina A. Logacheva, Alexander V. Belushkin, Polina A. Gergelezhiu, Alexander B. Eresko, Sergey N. Malakhov, Elena V. Raksha, Ludmila I. Savostina, Dorota M. Chudoba   +7 more
doaj   +1 more source

Evaluation of the neurotoxic effects of intrathecal administration of (S)-(+)-Ketoprofen on rat spinal cords: randomized controlled experimental study [PDF]

Revista Brasileira de Anestesiologia, 2019
Background and objectives Intrathecal administration of non-steroidal anti-inflammatory drugs is more efficacious for post-operative pain management.
Cengiz Kaya, Yunus O. Atalay, Bilge C. Meydan, Yasemin B. Ustun, Ersin Koksal, Sultan Caliskan   +5 more
doaj   +3 more sources

A model‐based analysis of the CYP2C9 genotype effects on fluconazole inhibition using flurbiprofen, ketoprofen and tolbutamide as probe drugs

British Journal of Pharmacology, EarlyView.
Background The activity of CYP2C9, an important drug metabolism enzyme, is subject to the impact of genetic polymorphism. The single nucleotide polymorphism *3 is significantly associated with the increased exposure of CYP2C9 substrates. In addition, metabolic enzyme inhibitors such as fluconazole may also increase the drug exposure of CYP2C9 ...
Shen Cheng, Darcy R. Flora, Mutaz M. Jaber, Allan E. Rettie, Richard C. Brundage, Timothy S. Tracy   +5 more
wiley   +1 more source

Идентификация и количественное определение сложных эфиров кетопрофена [PDF]

, 2018
Результаты исследований, обосновывающие подход к качественному и количественному определению сложных эфиров кетопрофена методом жидкостной хроматографии с использованием диодно-матричного детектора и масс ...
Безуглая, Е. П., Зинченко, И. А., Ляпунов, Н. А.   +2 more
core   +2 more sources

Update on diagnosis, nonpharmacological treatment and prevention of Equine Gastric Ulcer Syndrome (EGUS)

Equine Veterinary Education, EarlyView.
Summary The term Equine Gastric Ulcer Syndrome (EGUS) has been used since 1999. As there are important differences, the terms Equine Squamous Gastric Disease (ESGD) and Equine Glandular Gastric Disease (EGGD) were introduced in 2015. Risk factors like dietary management, training regimens and drug side effects, as described for NSAIDs, predispose ...
R. Lensing, A. K. Barton
wiley   +1 more source

Formulation, optimization and evaluation of sustained release microsphere of ketoprofen

Journal of Pharmacy and Bioallied Sciences, 2012
The objective of this study is to formulate ketoprofen loaded microspheres of Acrycoat S100 by an o/w emulsion solvent evaporation method. It potently inhibits the enzyme cyclooxygenase resulting in prostaglandin synthesis inhibition.
V Chirag Prajapati, P Rakesh Patel, G Bupendra Prajapati   +2 more
doaj   +1 more source

Unimolecular branched block copolymer nanoparticles in methanol for the preparation of poorly water-soluble drug nanoparticles [PDF]

, 2017
Unimolecular branched polymer nanoparticles are formed in methanol via a simple thermal annealing process, which can be used to produce aqueous drug nanoparticle suspensions.
He, Tao, Jackson, Alexander W, Liu, Jian-Hua, Wais, Ulrike, Wang, Yan-Hong, Xiang, Yu, Zhang, Haifei, Zuo, Yan-Ming   +7 more
core   +1 more source

Analgesic practices for acute pain management in cats and dogs in Africa

Journal of Small Animal Practice, EarlyView.
Objectives To understand perceptions and analgesic practices for acute pain management in cats and dogs by veterinarians in Africa. Materials and Methods Data from small animal veterinarians were collected using an online questionnaire (English/French) and convenience sampling.
S. S. U. H. Bukhari, J. C. Murrell, N. Lutevele, A. R. Ajadi, P. V. Steagall, B. P. Monteiro   +5 more
wiley   +1 more source

Comparative Evaluation of the Biochemical Effects of Ketamine plus Ketoprofen and Midazolam in the Premedication of Pigeons [PDF]

Archives of Razi Institute, 2018
The present study was conducted with the aim of comparing the effects of premedication with ketoprofen and midazolam in birds. A total of 24 male pigeons with an approximate weight of 300 g were divided into four equal groups. The control group (Group I)
H. Hajizadeh, G. Abedi, A. Asghari, S. Hesaraki   +3 more
doaj   +1 more source