Results 31 to 40 of about 11,650 (156)

Ketogal: A Derivative Ketorolac Molecule with Minor Ulcerogenic and Renal Toxicity

Frontiers in Pharmacology, 2017
Ketorolac is a powerful non-steroidal anti-inflammatory drug (NSAID), with a great analgesic activity, present on the Italian market since 1991. Despite the excellent therapeutic activity, the chronic use of ketorolac has long been limited owing to the ...
Roberto Russo, Carmen De Caro, Carmen De Caro, Bice Avallone, Salvatore Magliocca, Maria Nieddu, Gianpiero Boatto, Roberta Troiano, Rosario Cuomo, Carla Cirillo, Carmen Avagliano, Claudia Cristiano, Giovanna La Rana, Giovanni Sarnelli, Antonio Calignano, Maria G. Rimoli   +15 more
doaj   +1 more source

A comparative study of the effect of intravenous morphine and ketorolac on pain control in patients with renal colic

Advanced Biomedical Research, 2023
Background: The present study aimed at comparing the effect of ketorolac and morphine on the pain control in patients with renal colic. Materials and Methods: The present clinical trial was performed on 272 patients with renal colic that were divided ...
Seyed Mehdi Pourafzali, Abdolrahim Sanei, Ali Abdolrazaghnejad, Elahe Poursadra   +3 more
doaj   +1 more source

Preoperative caudal blocks associated with decreased cumulative opioid requirements compared to postoperative caudal blocks in pediatric urologic surgery

UroPrecision, EarlyView.
Abstract Background Caudal blocks (CB) are a cornerstone of pediatric urologic surgery, providing effective analgesia while mitigating potential neurotoxicity associated with general anesthesia and opioids. However, the optimal timing of CB—preoperative versus postoperative—remains controversial.
Jordan L. Mendelson, William Brenseke, Diego Alvarez Vega, William Nguyen, Mohammed Shium, Saige Gitlin, Ronnie G. Fine, Steven C. Friedman, Mark Horowitz, Walter I. Weiss, Raghu Idupuganti, Jordan S. Gitlin   +11 more
wiley   +1 more source

Effectiveness of Intraoperative Ketorolac in Outpatient Breast Surgery: A Double-blinded Prospective Randomized Controlled Trial

Plastic and Reconstructive Surgery, Global Open
Background:. The use of nonnarcotic analgesics, such as ketorolac, has been shown to reduce postoperative pain and opioid consumption. This double-blinded randomized trial is designed to assess the efficacy of intraoperative ketorolac in reducing ...
Joowon M. Choi, MBS, MD, Jose D. Rodriguez, MD, Michael A. Saccocci, DO, Robert P. Shafer, MD, Mark E. Feldmann, MD, Kurtis E. Moyer, MD, James T. Thompson, MD   +6 more
doaj   +1 more source

Postoperative Care and Management in Pediatric Hematology‐Oncology Patients

European Journal of Haematology, EarlyView.
ABSTRACT Pediatric patients with hematologic and oncologic diseases often undergo surgical procedures as part of diagnosis and therapy. These include central venous catheter placements, tumor resections, lymph node and bone marrow biopsies, among others.
Shachi Srivatsa, Sara A. Mansfield
wiley   +1 more source

Ex vivo corneal epithelial wound healing following exposure to ophthalmic nonsteroidal anti-inflammatory drugs

Clinical Ophthalmology, 2011
Keping Xu1, Mark McDermott1, Linda Villanueva2, Rhett M Schiffman2, David A Hollander21The Kresge Eye Institute, Department of Ophthalmology, Wayne State University School of Medicine, Detroit, MI, USA; 2Allergan, Inc., Irvine, CA, USAPurpose: Ketorolac ...
Keping Xu, Mark McDermott, Linda Villanueva, et al   +3 more
doaj  

Perbandingan Efektivitas Kombinasi Fentanyl–Paracetamol dan Fentanyl–Ketorolac terhadap Numerical Rating Scale (NRS) Post Operasi Seksio Sesarea

Jurnal Anestesi Obstetri Indonesia, 2020
Latar Belakang: Nyeri post operasi seksio sesarea merupakan nyeri sedang berat dengan intensitas akut. Saat ini terdapat dua kombinasi obat anti nyeri yang umum digunakan untuk mengatasi nyeri post operasi seksio sesarea yaitu kombinasi parasetamol ...
Andy H, Sugeng Budi Santoso, RTH Supraptomo   +2 more
doaj   +1 more source

Association Between Postoperative NSAID Use and Bleeding Following Transoral Robotic Surgery

Otolaryngology–Head and Neck Surgery, Volume 175, Issue 2, Page 402-408, August 2026.
Abstract Objective To evaluate the safety and outcomes of NSAID use following transoral robotic surgery (TORS). Study Design Retrospective cohort study using propensity score matching. Setting Multi‐institutional database (TriNetX). Methods Patients undergoing TORS were identified using ICD‐10 codes.
Brayden Seliger, Jacob Beiriger, Milana Berry, Nilam Patel, Richard B. Cannon, Marcus M. Monroe, Hilary C. McCrary   +6 more
wiley   +1 more source

Bioanalytical method validation to quantify ketorolac in human vitreous and aqueous via surrogate matrix of human plasma

Future Science OA
Purpose Intracameral phenylephrine 1.0%/ketorolac 0.3% (OMIDRIA®) is used during cataract surgery to prevent intraoperative miosis and reduce postoperative pain.
Prajita Pandey, Brianna A. White, Colin Goswell, Neelanjan Bose, Sara Butterworth Connell, Nicolee Schulze, Jim Nevelos, Ana Najafi, Ramin Najafi, Ryan K. Cheu   +9 more
doaj   +1 more source

Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods

Chirality, Volume 38, Issue 7, July 2026.
Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Burcu Karayavuz, Cigdem Karaaslan Kirmizioglu   +1 more
wiley   +1 more source