Results 71 to 80 of about 44,042 (276)
Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy [PDF]
, 2011 Background: Even in the presence of oxygen, malignant cells often highly depend on glycolysis for energy generation, a phenomenon known as the Warburg effect.
Maurer, Gabriele D. +8 more
core +1 more source
Animal Research and One Health, EarlyView.(1) Kbhb modification of FBP1 and PCK1 is involved in regulation of the gluconeogenesis pathway. (2) Kbhb of FBP1 and PCK1 is catalyzed by p300 and removed by HDACs. (3) BHB induced an increase in the enzymatic activity of FBP1 and PCK1 through Kbhb modification at the K43 site of FBP1 and the K191 site of PCK1.
DingPing Feng +6 more
wiley +1 more source
Frontiers in Veterinary Science, 2021 Currently, ketosis has no fully satisfactory resolution in dairy cows. Here, we investigated the effect of levocarnitine or vitamin B complex and E with selenium on clinically ketotic cows (β-hydroxybutyrate ≥ 3.0 mmol/L and decreased milk yield), fed ...
Seungmin Ha +6 more
doaj +1 more source
Animal Research and One Health, EarlyView.The transition period in dairy cows, spanning 3 weeks before and after calving, is a critical phase characterized by increased nutrient demands, reduced dry matter intake (DMI), and elevated risk of metabolic disorders such as negative nutrient balance (NNB), lipolysis, proteolysis, and oxidative stress.
Mohammed S. Seleem +5 more
wiley +1 more source
Ketosis prone diabetes presenting as fulminant type 1 diabetes
The Pan African Medical Journal, 2018 Patients with ketosis prone diabetes have been reported primarily in Africans and African Americans. At presentation, both insulin secretion and insulin action are impaired in ketosis prone diabetes patients.
Katerina krompa +6 more
doaj +1 more source
Metabolomic and Proteomic Profiles Associated With Ketosis in Dairy Cows
Frontiers in Genetics, 2020 Ketosis is a common metabolic disease in dairy cows during early lactation. However, information about the metabolomic and proteomic profiles associated with the incidence and progression of ketosis is still limited.
Zhou-Lin Wu +5 more
doaj +1 more source
Animal Research and One Health, EarlyView.Unregulated inflammation increases non‐esterified fatty acids (NEFAs), and triggers multi‐pathway hepatocyte damage including oxidative stress, mitochondrial dysfunction, and metabolic disorders in dairy cows. ABSTRACT Circulating concentrations of nonesterified fatty acids (NEFAs) are elevated due to lipid mobilization from adipose tissue in ...
Siqing Mao +12 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective Late onset epilepsy (LOE) is associated with substantial morbidity. Sodium‐glucose cotransporter 2 inhibitors (SGLT2i) may exert neuroprotective effects. This study evaluated the association between SGLT2i and risk of LOE among older adults with type 2 diabetes mellitus.
Bing‐Hua Lin +3 more
wiley +1 more source
Estimating the combined costs of clinical and subclinical ketosis in dairy cows
PLoS ONE, 2020 Clinical ketosis (CK) and subclinical ketosis (SCK) are associated with lower milk production, lower reproductive performance, an increased culling of cows and an increased probability of other disorders.
W. Steeneveld +4 more
semanticscholar +1 more source
A participatory approach to design monitoring indicators of production diseases in organic dairy farms [PDF]
, 2016 Production diseases have an important negative effect on the health and welfare of dairy cows. Although organic animal production systems aim for high animal health levels, compliance with European organic farming regulations does not guarantee that this
Bareille, Nathalie +5 more
core +2 more sources