Results 111 to 120 of about 23,218 (270)

Ser-Phosphorylation of PCSK9 (Proprotein Convertase Subtilisin-Kexin 9) by Fam20C (Family With Sequence Similarity 20, Member C) Kinase Enhances Its Ability to Degrade the LDLR (Low-Density Lipoprotein Receptor) [PDF]

, 2019
Ali Ben Djoudi Ouadda, Marie-Soleil Gauthier, Delia Susan‐Resiga, Emmanuelle Girard, Rachid Essalmani, Miles H. Black, Jadwiga Marcinkiewicz, Diane Forget, Josée Hamelin, Alexandra Evagelidis, Kévin Ly, Robert Day, Luc Galarneau, François Corbin, Benoit Coulombe, Artuela Çaku, Vincent S. Tagliabracci, Nabil G. Seidah   +17 more
openalex   +1 more source

Rationale and Design of the PASSIVATE‐CAP Trial: The Preventive Intervention Value of Drug‐Coated Balloons in Vulnerable Coronary Atherosclerotic Plaques

Clinical Cardiology, Volume 49, Issue 1, January 2026.
PASSIVATE‐CAP Research Overview and Flowchart. ABSTRACT Background Patients with acute coronary syndrome (ACS) face a significantly increased risk of cardiovascular events due to vulnerable plaques. However, no clear evidence supports performing preventive percutaneous coronary intervention (PCI) for non‐flow‐limiting vulnerable plaques.
Zhongxiu Chen, Junyan Zhang, Minggang Zhou, Shichu Liang, Yong Chen, Chen Li, Hua Wang, Jiafu Wei, Baotao Huang, Mian Wang, Yong He, for the PASSIVATE‐CAP trial investigator   +11 more
wiley   +1 more source

Research on experiment for operation performance of water pumping and energy storage by photovoltaic pump

Energy Exploration & Exploitation
In this article, the behaviors of both flow and generated output of photovoltaic pump, the characteristics of both water pumping efficiency and output frequency, and the feature of charge capacity in accumulators have been tested through experiments ...
Yanjin Wang, Linchao Gao, Yi Xie, Fuping Shen, Qingying Hao, Bing Jia   +5 more
doaj   +1 more source

Efficacy and safety of proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors, alirocumab and evolocumab, a post-commercialization study [PDF]

, 2017
Joshua Choi, Amir Khan, Michael Jarmin, Naila Goldenberg, Charles J. Glueck, Ping Wang   +5 more
openalex   +1 more source

Optimization of 4‐Amino‐2‐Pyridone Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9: Integrating Structure–Activity and Structure–Metabolism Relationships

ChemMedChem, Volume 21, Issue 1, January 2026.
Green chemistry‐based late‐stage functionalization (LSF) of the anti‐proprotein convertase subtilisin/kexin type 9 (PCSK9) early lead compound 5c led to optimized analogs with improved metabolic stability/PCSK9 IC50 ratio. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key drug target for the treatment of different hypercholesterolemia ...
Lisa Giannessi, Maria Giovanna Lupo, Martina Ugolotti, Bianca Papotti, Beatrice Mattina, Maria Grazia Martina, Anna Demurtas, Cristina Padula, Sara Nicoli, Marco Crescenzio, Nicola Ferri, Francesca Zimetti, Marco Radi   +12 more
wiley   +1 more source

Statins Versus Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors- Are We Doing Better? A Systematic Review on Treatment Disparity [PDF]

, 2020
Chetana Singh, Danel J Valero, Javariya Nisar, J. I. Ramirez, Karisma K Kothari, Sasank Isola, Aleyda M San Hernandez, Domonick K Gordon   +7 more
openalex   +1 more source

Long non‐coding RNA lncAPAT promotes atherosclerotic plaque instability by targeting ribosomal protein L22

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
LncAPAT interacted with the promoter region of RPL22 to inhibit RPL22 transcriptional activity and increase the expression of MCP‐1, thereby contributing to plaque instability. Abstract Background Long non‐coding RNAs (lncRNAs) regulate macrophage inflammation and atherosclerotic plaque stability, but mechanisms need comprehensive investigations ...
Rongxia Li, Qiyue Zhang, Yu Chen, Shuting Wang, Shuang Han, Adalaiti Kamili, Yixuan Zhong, Shujun Yang, Weili Zhang   +8 more
wiley   +1 more source

Serum Proprotein Convertase Subtilisin/Kexin Type 9 and Cell Surface Low-Density Lipoprotein Receptor [PDF]

, 2013
Hagai Tavori, Daping Fan, John Blakemore, Patricia G. Yancey, Lei Ding, MacRae F. Linton, Sergio Fazio   +6 more
openalex   +1 more source

Proproteinkonvertase Subtilisin/Kexin Typ 9 [PDF]

, 2018
K. J. Lackner, D. Peetz
openaire   +2 more sources

Targeting the lactylation of ENO1 alleviates endothelial dysfunction in sepsis

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Lactylation of ENO1 reduced the binding of TRIM21 mRNA to ENO1, thereby preventing mRNA degradation. Elevated TRIM21 subsequently binds to VE‐Cadherin, promoting its ubiquitination. Targeting the lactylation of ENO1 with a specific inhibitory peptide alleviated endothelial dysfunction.
Xueru Xie, Tingyan Liu, Caiyan Zhang, Ye Cheng, Yajing Gao, Wenfeng Xiao, Haiyan Guo, Yutong Zhou, Yawei Yu, Kexin Wang, Yinghong Lin, Lisheng Xiao, Yingying Zhang, Weiguo Yang, Gangfeng Yan, Guoping Lu, Yufeng Zhou   +16 more
wiley   +1 more source