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Safety evaluation of an extension of use of the food enzyme subtilisin from the non‐genetically modified Bacillus licheniformis strain NZYM‐CX [PDF]
EFSA JournalThe food enzyme subtilisin (EC 3.4.21.62) is produced with the non‐genetically modified Bacillus licheniformis strain NZYM‐CX by Novozymes A/S. The safety of this food enzyme was evaluated previously and it did not give rise to safety concerns when used ...
EFSA Panel on Food Enzymes (FEZ) +15 more
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Exploring Subtilisin Inhibition to Discover Antimalarial Drugs: Insights into Medicinal Chemistry and Drug Discovery [PDF]
PharmaceuticalsIntroduction: Malaria is a tropical disease caused by the parasite Plasmodium sp., which is considered a significant public health challenge, particularly in Africa. Among the species related to human infection, P. falciparum and P.
Margarida Cochicho Leonardo +8 more
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Characterization of drought-responsive subtilisin genes in upland rice: the role of OsSub14 in ABA signaling and ROS accumulation [PDF]
BMC Plant BiologyBackground Drought stress presents a significant challenge to rice production, affecting global food security. The protein degradation pathway is vital for regulating plant drought stress responses. Subtilisins, a family of serine proteases, are known to
Yifan Wang +8 more
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Journal of Fungi, 2021 Skin infections by keratinophilic fungi are commonly referred to as dermatophytosis and represent a major health burden worldwide. Although patient numbers are on the rise, data on virulence factors, their function and kinetics are scarce. We employed an
Christina-Marie Baumbach +5 more
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Frontiers in Fungal Biology, 2022 The growth and development of organisms depend on nutrient availability. Dermatophytes must sense nutrient levels and adapt to the host environment to colonize human and animal keratinized tissues.
Aline H. S. Cruz +9 more
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Nattokinase historical sketch on experimental and clinical evidence
Italian Journal of Medicine, 2023 Nattokinase (NK) is a protease derived from food used mainly in the Japanese diet that has several properties. The main activity is related to improving fibrinolytic activities. Other activities have been demonstrated in the regulation of blood pressure
Pierpaolo Di Micco +7 more
doaj +1 more source
EFSA Journal, 2023 The food enzyme subtilisin (serine endopeptidase, EC 3.4.21.62) is produced with the non‐genetically modified microorganism Bacillus paralicheniformis strain LMG S‐30155 by ENMEX SA de CV, now part of Kerry Food Ingredients (Cork) Ltd. The food enzyme is
EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP) +23 more
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PF-429242, a Subtilisin Inhibitor, Is Effective in vitro Against Leishmania infantum
Frontiers in Microbiology, 2021 PF-429242 is an inhibitor of subtilisin, an important protease found in Leishmania. However, studies regarding the effect of PF-429242 on Leishmania are scarce. In this work we evaluated the antileishmanial effect of PF-429242 against Leishmania infantum
Patrícia de Almeida Machado +10 more
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Proceedings of the National Academy of Sciences, 1973 Subtilisin reacts at pH 6.8-7.8 with p -nitrophenyl diazoacetate to release p -nitrophenol and form diazoacetyl subtilisin. Although at pH 7.8 this derivative rapidly undergoes hydrolytic cleavage to regenerate active enzyme, the derivative can be ...
Y, Stefanovsky, F H, Westheimer
openaire +2 more sources
FEBS Open Bio, 2023 Subtilisins from microbial sources, especially from the Bacillaceae family, are of particular interest for biotechnological applications and serve the currently growing enzyme market as efficient and novel biocatalysts.
Fabian Falkenberg +4 more
doaj +1 more source