Biochemical characterisation of a novel broad pH spectrum subtilisin from Fictibacillus arsenicus DSM 15822T [PDF]
FEBS Open Bio, 2023 Subtilisins from microbial sources, especially from the Bacillaceae family, are of particular interest for biotechnological applications and serve the currently growing enzyme market as efficient and novel biocatalysts.
Fabian Falkenberg +4 more
doaj +2 more sources
Phylogenetic survey of the subtilase family and a data-mining-based search for new subtilisins from Bacillaceae [PDF]
Frontiers in Microbiology, 2022 The subtilase family (S8), a member of the clan SB of serine proteases are ubiquitous in all kingdoms of life and fulfil different physiological functions.
Fabian Falkenberg +3 more
doaj +2 more sources
Biochemical characterization of a novel oxidatively stable, halotolerant, and high‐alkaline subtilisin from Alkalihalobacillus okhensis Kh10‐101T [PDF]
FEBS Open Bio, 2022 Halophilic and halotolerant microorganisms represent a promising source of salt‐tolerant enzymes suitable for various biotechnological applications where high salt concentrations would otherwise limit enzymatic activity.
Fabian Falkenberg +5 more
doaj +2 more sources
New and Investigational Treatment Options for Dermatomycosis in the Era of Antifungal Resistance [PDF]
Journal of FungiSuperficial mycoses (dermatomycoses) are a growing healthcare concern due to antifungal resistance, particularly among aging and immunocompromised populations.
Aditya K. Gupta, Amanda Liddy, Tong Wang
doaj +2 more sources
Surface‐associated residues in subtilisins contribute to poly‐L‐lactic acid depolymerization via enzyme adsorption [PDF]
Microbial BiotechnologyPoly‐L‐lactic acid (PLLA) is currently the most abundant bioplastic; however, limited environmental biodegradability and few recycling options diminish its value as a biodegradable commodity.
Jordan A. Cannon +3 more
doaj +2 more sources
PLoS ONE, 2011 Combinatorial fragment exchange was utilised to recombine key structural and functional low homology regions of bacilli subtilisins to generate new active hybrid proteases with altered substrate profiles.
D Dafydd Jones
exaly +3 more sources
Characterization of drought-responsive subtilisin genes in upland rice: the role of OsSub14 in ABA signaling and ROS accumulation [PDF]
BMC Plant BiologyBackground Drought stress presents a significant challenge to rice production, affecting global food security. The protein degradation pathway is vital for regulating plant drought stress responses. Subtilisins, a family of serine proteases, are known to
Yifan Wang +8 more
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Exploring Subtilisin Inhibition to Discover Antimalarial Drugs: Insights into Medicinal Chemistry and Drug Discovery [PDF]
PharmaceuticalsIntroduction: Malaria is a tropical disease caused by the parasite Plasmodium sp., which is considered a significant public health challenge, particularly in Africa. Among the species related to human infection, P. falciparum and P.
Margarida Cochicho Leonardo +8 more
doaj +2 more sources
New insights into the evolution of subtilisin-like serine protease genes in Pezizomycotina [PDF]
BMC Evolutionary Biology, 2010 Background Subtilisin-like serine proteases play an important role in pathogenic fungi during the penetration and colonization of their hosts. In this study, we perform an evolutionary analysis of the subtilisin-like serine protease genes of subphylum ...
Zhang Ying +9 more
doaj +3 more sources
Prodomain-driven enzyme dimerization: a pH-dependent autoinhibition mechanism that controls Plasmodium Sub1 activity before merozoite egress [PDF]
mBioMalaria symptoms are associated with the asexual multiplication of Plasmodium falciparum within human red blood cells (RBCs) and fever peaks coincide with the egress of daughter merozoites following the rupture of the parasitophorous vacuole (PV) and the
Mariano Martinez +6 more
doaj +2 more sources