Results 111 to 120 of about 48,363 (248)
The FASEB Journal, Volume 40, Issue 9, 15 May 2026.In patients with severe obesity, periodontitis is associated with oral microbiota dysbiosis which influences gut microbiota composition by increasing Proteobacteria proportion. These alterations are linked to systemic immune and metabolic changes, including higher circulating levels of anti‐Porphyromonas gingivalis lgG and deregulated lipid profile ...
Katy Thouvenot +11 more
wiley +1 more source
MoleculesG-quadruplex (G4), an important secondary structure of nucleic acids, is polymorphic in structure. G4 monomers can associate with each other to form multimers, which show better application performance than monomers in some aspects.
Ju Wang +6 more
doaj +1 more source
The Sirt1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression [PDF]
, 2017 Aims The deacetylase sirtuin 1 (Sirt1) exerts beneficial effects on lipid metabolism, but its roles in plasma LDL-cholesterol regulation and atherosclerosis are controversial.
Arsiwala, Tasneem +17 more
core
CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.A mouse CIRI model was generated by middle cerebral artery occlusion. HBO‐PC and LRG1 siRNA knockdown were applied. Neurological function and molecular changes were evaluated. We confirmed that HBO‐PC reprograms neuroimmune metabolism through disruption of the LRG1‐HIF‐1α‐IL‐6‐STAT3 amplification Loop attenuates pyroptosis and ischemia–reperfusion ...
Wenying Lv +5 more
wiley +1 more source
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.This meta‐analysis of randomized trials evaluates olezarsen for hypertriglyceridemia in patients at high cardiovascular risk. Olezarsen significantly improved triglycerides and other atherogenic lipid parameters with generally acceptable safety, supporting its potential as a promising adjunct therapy while highlighting the need for larger and longer ...
Ahmed Emara +9 more
wiley +1 more source
Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.ABSTRACT Barth syndrome (BTHS; OMIM 302060) is an ultra‐rare, life‐limiting genetic disorder characterized by cardiomyopathy, skeletal muscle myopathy, neutropenia, gastrointestinal issues, and fatigue. Formal analyses of survival and clinical progression remain limited.
Kexin Fu +7 more
wiley +1 more source
Медицина в Кузбассе, 2019 Increased serum low-density lipoprotein (LDL) concentrations are clearly the most important risk factors for cardiovascular diseases. Currently, statins are the most widely used drugs for treating patients with hypercholesterolemia, however, in some ...
Алексей Михайлович Чаулин +3 more
doaj
Expanding the genotypic spectrum of PCSK1 deficiency: A novel mutation in severe neonatal diarrhea
JPGN Reports, Volume 7, Issue 2, Page 242-246, May 2026.Abstract Among congenital diarrhea and enteropathies (CODEs), proprotein convertase subtilisin/kexin type 1 (PCSK1) deficiency is a rare monogenic disorder, associated with severe neonatal diarrhea and polyendocrinopathies. We report an 18‐day‐old male neonate, born to consanguineous parents, presenting with persistent watery diarrhea, metabolic ...
Eleonora Saraceno +7 more
wiley +1 more source
Lipids, Volume 61, Issue 3, Page 319-329, May 2026.ABSTRACT Ischemic stroke is frequently associated with symptomatic intracranial atherosclerotic stenosis (sICAS), is a leading cause of global disability and mortality. Current guidelines recommend dual antiplatelet and intensive statin therapies. Proprotein convertase subtilisin 9/kexin type 9 (PCSK9) inhibitors have emerged as a potent lipid‐lowering
Chao Zhao +5 more
wiley +1 more source
Biohybrids for Health Care: Towards Next‐Generation Biomaterials Application
MedComm – Biomaterials and Applications, Volume 5, Issue 2, June 2026.
Kexin Zhang, Qiankun Zhu, Can Wang
wiley +1 more source