Aging Cell, Volume 25, Issue 1, January 2026.This article supports that ANGPTL4 secreted factor is induced transcriptionally and activated by proteolytic cleavage during senescence, contributing to the production of a pro‐inflammatory SASP. In the senescent cell microenvironment, ANGPTL4 could thus contribute to senescence‐dependent alterations such as inflammation and tumor initiation.
Gabriela Makulyte +20 more
wiley +1 more source
SAT-LB95 Low Density Lipoprotein Receptor and Proprotein Convertase Subtilisin/Kexin Type 9 Kinetics Using Heavy Water (2H2O) Labeling and Mass Spectrometry [PDF]
, 2020 Mohamad Dandan, Marc K. Hellerstein
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Addressing unmet needs for chronic kidney disease treatment in type 1 diabetes: A review
Diabetes, Obesity and Metabolism, Volume 28, Issue 1, Page 16-26, January 2026.Abstract Chronic kidney disease (CKD) is a serious complication occurring in nearly one of three people with type 1 diabetes (T1D). Major therapeutic advances have been made in the management of CKD for people with type 2 diabetes (T2D), thereby improving their kidney, cardiovascular, and survival outcomes.
Katherine R. Tuttle +3 more
wiley +1 more source
Revisiting Assisted Reproductive Technology (ART) - Related Psychological Symptom Clusters [Letter]
International Journal of Women's HealthHuimin Du,1 Kexin Wang2 1First Affiliated Hospital of Huzhou University, Huzhou, Zhejiang People’s Republic of China; 2Gynecology Department, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumchi, People’s Republic of ...
Du H, Wang K
doaj
[Proprotein convertase subtilisin/kexin type 9 (PCSK9) and inhibitors].
Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir, 2015 Hypercholesterolemia is a major risk factor for atherosclerosis. Low-density lipoprotein cholesterol (LDL-C) lowering drugs reduce cardiovascular morbidity and mortality. However, many individuals treated with statins do not achieve their target levels of LDL-C.
Ahmet, Avci +2 more
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TDP‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models
The FEBS Journal, Volume 293, Issue 2, Page 348-384, January 2026.The manuscript explores structural and functional features of TDP‐43 and its worm homologue, TDP‐1, highlighting conserved and divergent structural and functional features. Using genetically engineered C. elegans models, key pathological features of TDP‐43 proteinopathies—including aggregation, neurodegeneration, and motor deficits—are recapitulated ...
Ghulam Jeelani Pir +7 more
wiley +1 more source
Elevation of serum proprotein convertase subtilisin/kexin type 9 (PCSK9) concentrations and its possible atherogenic role in patients with systemic lupus erythematosus [PDF]
, 2018 Chenglong Fang, Tingting Luo, Ling Lin
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The role of orexin A in the pathogenesis of ischaemic stroke at high altitude
Experimental Physiology, Volume 111, Issue 1, Page 257-269, 1 January 2026.Schematic illustration of the experimental design. This study investigated the role of Orexin A in the pathogenesis of ischemic stroke at high altitude. Abstract Orexin offers protection against cerebral ischaemia–reperfusion injury, with high altitude playing a key role in modulating its expression.
Minxia Zhu +7 more
wiley +1 more source
Modeling and Simulation to Support Phase 2 Dose Selection for RG7652, a Fully Human Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9 [PDF]
, 2015 Nageshwar Budha +7 more
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