Results 201 to 210 of about 1,054,507 (259)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

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Key agreement for key hypergraph

Computers & Security, 2007
In this paper, we propose a key agreement protocol for a key hypergraph. In a key hypergraph, a party is represented as a vertex and a group of parties is represented as a hyperedge. A key agreement protocol for a key hypergraph establishes all the keys for hyperedges in a key hypergraph at the same time.
Ik Rae Jeong, Dong Hoon Lee 0001
openaire   +1 more source

Lightweight key agreement with key chaining

The 7th IEEE International Conference on Mobile Ad-hoc and Sensor Systems (IEEE MASS 2010), 2010
Small ad-hoc wireless networks are becoming ubiquitous. Wireless protocols like ZigBee, ANT, and Bluetooth have been targeted towards small devices with limited capabilities. As the volume and sensitivity of data being communicated over these networks increases so does the need for security. The limited capabilities of these devices, however, means the
Paul Krier, Sai Seshabhattar, Jason Pereira, Daniel W. Engels, Suku Nair   +4 more
openaire   +1 more source

Tunable Group Key Agreement

32nd IEEE Conference on Local Computer Networks (LCN 2007), 2007
Secure group communication has various applications. Requirements for an application differ in various parameters such as tolerance times for join and leave, arrival rate, departure rate, staying period and group life time. Existing group key agreement protocols do not harness knowledge of application requirements.
Rajesh Ingle, G. Sivakumar
openaire   +2 more sources

On the Security of a Key Agreement and Key Protection Scheme

IEEE Transactions on Information Forensics and Security, 2020
We point out that the key agreement and key protection scheme (published in IEEE Transactions on Information Forensics and Security, doi: 10.1109/TIFS.2018.2850299) fails to achieve the two-factor security. We demonstrate that in the scheme, if an adversary can control the master device of a target user, he can impersonate the user to pass the server’s
Yunxia Han, Chunxiang Xu, Debiao He, Kefei Chen   +3 more
openaire   +1 more source

The GN-authenticated key agreement

Applied Mathematics and Computation, 2005
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
George Stephanides, Nicolae Constantinescu   +1 more
openaire   +1 more source