Results 61 to 70 of about 15,095 (267)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
COMPETENCES OF YOUNG UNIVERSITY TEACHERS IN THE ERA OF COGNITIVE REVOLUTION
Russian Journal of Education and PsychologyBackground. The changing goals of higher education and expectations from the university graduates with the advent of Industry 4.0 particularly acutely raise the problem of university teachers' competences.
Li RuiTing, Tatiana E. Isaeva
doaj +1 more source
THE EUROPEAN DIMENSION OF THE COMPETENCE-BASED SCHOOL EDUCATION IN UKRAINE [PDF]
Revista de Pedagogie, 2018 The adoption of the Lisbon Strategy (2000) and of the European Reference Framework on Key Competences for Lifelong Learning (2006) launched a competence-based approach in the EU member states education systems.
Olena LOKSHYNA
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Old or Not: Competency Is the Key [PDF]
The Journal of Continuing Education in Nursing, 2021 openaire +2 more sources
Digital competence – A Key Competence for Todays and Future Physicians [PDF]
Journal of European CME, 2022 Nilufar Foadi, Julian Varghese
openaire +3 more sources
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Professional requirements for a sociocultural animator: key competences
Pedagogía Social: Revista Interuniversitaria, 2013 This article comes from a project sponsored by AECID of Educational Intervention on Social contexts and it approaches a specific dimension.As they contribute to solve several problems, sociocultural professionals claim for higher recognition. Given their
Mª Luisa Sarrate Capdevila +2 more
doaj +1 more source