Results 61 to 70 of about 28,836 (311)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Is Multilingualism the key competence?
, 2021 Key-Co System has promoted targeted research, led by the University of Reading, on Multilingualism, that is deemed as a pivotal competence, especially with regard to Adult Migrant Learners (AMLs) and their educational needs.\ud \ud The result of this research work is “Is Multilingualism the key competence?”, a paper written by Cecilia Defilippi and ...
Defilippi, Cecilia, Faloppa, Federico
openaire
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Education: Modern Discourses, 2019 The article addresses an issue of structuring the natural science school education content and substantiates the trends of its modernization under orientation at the all-round development of a personality.
Оleg Topuzov, Mykola Golovko
doaj +1 more source
Effective Management of Urban Affairs by Promoting Core Competencies in Zahedan Municipality [PDF]
پژوهشهای مدیریت عمومی, 2019 Extended Abstract Abstract The most important and most important asset of any organization is its human resources. Quality and capability of human resources is the most important factor in the survival of the organization.
Masoume Zaree kaseb, AminReza Kamalian
doaj +1 more source
Critical Thinking as a Key Competency [PDF]
Proceedings of the 3d International Conference on Applied Social Science Research, 2016 This paper focuses on the key competency of critical thinking and the perception of this competency as a basic building block of media literacy. It operates with the terms media education, media literacy, critical thinking and new media. It also covers the inclusion of media education in international documents.
Monika Hossova, Dana Petranova
openaire +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
ECNU Review of Education, 2020 Purpose: This article aims to conduct a critical analysis of key-competences-based education in China today by revealing three main challenges that Chinese educational practitioners, researchers, and policymakers might face.
Kang Zhao
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Education Sciences, 2020 The third sector represents a vast and heterogeneous universe that has a key role in society from both the social and civil points of view. It also represents an informal learning context where competence and knowledge are acquired, often in a tacit and ...
Paolo Di Rienzo
doaj +1 more source