Results 41 to 50 of about 28,836 (311)

LIFELONG LEARNING ESSENTIAL CONDITION FOR INCLUSION IN A KNOWLEDGE-BASED ECONOMY [PDF]

Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2023
Lifelong learning is essential to support competitiveness and social inclusion. In the article, aspects of the organization of the lifelong learning process are studied, such as: strategies, forms of learning and directions for inclusion in the concept
ABRAMIHIN CEZARA, PhD Associate Professor, ȘARAI NATALIA, Master of economics   +1 more
doaj  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The strategic framework for European cooperation in education and training (ET 2020): Which place for archaeological heritage in the lifelong learning context? [PDF]

Munibe Antropologia-Arkeologia, 2012
The Lisbon Strategy objective of turning Europe into a world-leading knowledge-based society, has left the way to the Europe 2020 strategyobjectives of smart, sustainable and inclusive growth. The strategic framework for European cooperation in education
Martínez Rodríguez, R., Errazkin Agirrezabala, M.   +1 more
doaj  

Collaboration : A key competence for competing in the 21st Century [PDF]

, 2008
It is now an accepted fact that in the 21st century competition will be between networks of organisations and individuals, which efficiently and effectively integrate their competencies and resources in order to compete in a global economy (Bititci et al, 2004). Similarly the SME’2000 conference, which was held in Bologna, conclude that “SMEs belonging
Bititci, Umit, Butler, P., Cahill, William, Kearney, Denis   +3 more
openaire   +3 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Improving teaching capacity to increase student achievement: The key role of communication competences in Higher Education

, 2019
The educational model based on competences established under the unifying framework of the European Higher Education Area (EHEA), has brought new challenges and threats for educational institutions at university level, who now have to adapt, update and ...
Rodríguez López, Ángel, Jaime E. Souto, Arroyo Noblejas, María Luisa, Souto Pérez, Jaime Eduardo, María Luisa Arroyo Noblejas, Ángel Rodríguez López   +5 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source