Results 51 to 60 of about 5,788,069 (303)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

RESEARCH ACTIVITY OF THE STUDENTS IN PHYSICS AS A MEANS OF IMPLEMENTATION OF COMPETENCE-BASED APPROACH

Вестник Северо-Кавказского федерального университета, 2022
This article considers the problem of implementation of competence-based approach in terms of Russian education. The author focuses special attention on the development the key competencies of the pupils and the development of cognitive interest in ...
Anna P. Velihanova
doaj  

Formation of pupils’ key competences in Physics classes basing on the task-oriented approach

Науковий Вісник Південноукраїнського Національного Педагогічного Університету імені К. Д. Ушинського, 2019
The purpose of the study was the development, selection and implementation of high-quality physical tasks and situational tasks into the school course «Physics 8», as the conditions for positive motivation to study Physics and form pupils’ key ...
Kaplun Viktoriia, Marina Mariia , Tadeush Olga   +2 more
doaj   +1 more source

Learnin to learn: grounding the future of education

Studi sulla Formazione, 2022
The paper is a dialogue with Gregory Bateson and Alvin Toffler, prophetic thinkers that in the middle of the 20th century envisaged, and called for, the education of the future.
Eugenia Giovanna Campanella, Patrizia Giordano   +1 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Psychological methods of forming key competences [PDF]

, 2020
Описані психологічні методи формування ключових компетентностей.Psychological methods of forming key competences ...
Доротюк, О.Г.
core   +1 more source

Critical Thinking as a Key Competency [PDF]

Proceedings of the 3d International Conference on Applied Social Science Research, 2016
This paper focuses on the key competency of critical thinking and the perception of this competency as a basic building block of media literacy. It operates with the terms media education, media literacy, critical thinking and new media. It also covers the inclusion of media education in international documents.
Monika Hossova, Dana Petranova
openaire   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Practices in Integrating Workplace Learning into Upper Secondary Education

Social Sciences
In recent years, Estonian employers, upper secondary schools, and other stakeholders have devised various new collaborative measures to effectively integrate workplace learning (WPL) and school education.
Birgit Peterson, Krista Loogma, Maret Aasa   +2 more
doaj   +1 more source