Results 51 to 60 of about 103,973 (310)

MODEL OF INTEGRAL KEY COMPETENCE OF FUTURE QUALIFIED WORKERS OF SEWING PROFILE

open access: yesНеперервна професійна освіта: теорія та практика, 2021
The article raises the issue of the lack of a list of current key competencies required by the modern labor market of the garment industry in the State Standards of Vocational Education for the professions «Tailor» and «Cutter».
Halyna Оdnoroh
doaj   +1 more source

Key Competencies of Physics Teachers

open access: yesHigher Education Studies, 2020
In China, the main goal of basic education curriculum reform is to develop students' key competencies. The physics teaching directed by key competencies would not only aim at the memory and reappearance of physics knowledge but also the application of physics knowledge and methods.
Tingting Liu, Haibin Sun
openaire   +2 more sources

Establishing the "new" into "the way we do things": Reviewing paper aims and content in response to national and local developments.

open access: yes, 2010
This paper reports on a review of "Professional practice and inquiry I" in response to local and national developments. The introduction of The New Zealand Curriculum (Ministry of Education, 2007) raised questions for initial teacher educators about how ...
Earl Rinehart, (Suzanne) Kerry
core   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Problems in Teaching Physics at Technical Universities

open access: yesAnnals of West University of Timisoara: Physics, 2013
The paper deals with the problem of decreasing level of knowledge of university students due to the changes of the school system in Slovakia. As the commonly repeated words connected with education in 21st.century are key competencies, we tried to look ...
Banik Ivan   +3 more
doaj   +1 more source

Critical Thinking as a Key Competency [PDF]

open access: yesProceedings of the 3d International Conference on Applied Social Science Research, 2016
This paper focuses on the key competency of critical thinking and the perception of this competency as a basic building block of media literacy. It operates with the terms media education, media literacy, critical thinking and new media. It also covers the inclusion of media education in international documents.
Monika Hossova, Dana Petranova
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

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