Results 91 to 100 of about 2,764,347 (308)

Microglial double stranded DNA accumulation induced by DNase II deficiency drives neuroinflammation and neurodegeneration

open access: yesJournal of Neuroinflammation
Background Deoxyribonuclease 2 (DNase II) is pivotal in the clearance of cytoplasmic double stranded DNA (dsDNA). Its deficiency incurs DNA accumulation in cytoplasm, which is a hallmark of multiple neurodegenerative diseases.
Ling-jie Li   +7 more
doaj   +1 more source

Evaluation of the organisation and delivery of patient-centred acute nursing care [PDF]

open access: yes, 2006
In 2002, a team of researchers from the School of Nursing, University of Salford were commissioned by Bolton Hospitals NHS Trust to evaluate the delivery and organisation of patient-centred nursing care across the acute nursing wards within the Royal ...
Haigh, CA, Ormandy, P, Solomon, JM
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Engineered microbial platform confers resistance against heavy metals via phosphomelanin biosynthesis

open access: yesNature Communications
Environmental concerns are increasingly fueling interest in engineered living materials derived from microbial sources. Melanin biosynthesis in microbes, particularly facilitated by recombinant tyrosinase expression, offers sustainable protection for the
Xiaokang Ren   +7 more
doaj   +1 more source

Efficient Peroral Delivery of Insulin via Vitamin B12 Modified Trimethyl Chitosan Nanoparticles

open access: yesJournal of Pharmacy & Pharmaceutical Sciences, 2015
PURPOSE: We investigated the effect of vitamin B12 (VB12) modification on the insulin absorption from trimethyl chitosan(TMC) nanoparticles (NPs) under the influence of mucus.
Zhiyang Ke   +4 more
doaj   +1 more source

Reducing Inequalities in Water Supply, Sanitation, and Hygiene in the Era of the Sustainable Development Goals [PDF]

open access: yes, 2017
The Sustainable Development Goals (SDGs) and the World Bank's corporate goals of ending extreme poverty and boosting shared prosperity call for specific attention to the poor and vulnerable.
Craig Kullman   +3 more
core   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

A network approach to overcoming barriers to market engagement for SMEs in energy efficiency initiatives such as the Green Deal [PDF]

open access: yes, 2016
The Green Deal (GD) was launched in 2013 by the UK Government as a market-led scheme to encourage uptake of energy efficiency measures in the UK and create green sector jobs.
Gilmour, Daniel J.   +2 more
core   +3 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

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