Results 121 to 130 of about 361,970 (307)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Round Optimal Fully Secure Distributed Key Generation [PDF]

open access: yes
Protocols for distributed (threshold) key generation (DKG) in the discrete-logarithm setting have received a tremendous amount of attention in the past few years. Several synchronous DKG protocols have been proposed, but most such protocols are not fully
Jonathan Katz
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Spi2Java: automatic cryptographic protocol java code generation from spi calculus [PDF]

open access: yes, 2004
Pozza, Davide   +3 more
core   +1 more source

Session-Key Generation Using Human Passwords Only [PDF]

open access: yes, 2005
We present session-key generation protocols in a model where the legitimate parties share only a human-memorizable password, and there is no additional setup assumption in the ...
Yehuda Lindell, Oded Goldreich
core  

Secure agent data integrity shield

open access: yes, 2004
In the rapidly expanding field of E-Commerce, mobile agent is the emerging technology that addresses the requirement of intelligent filtering/processing of information. This paper will address the area of mobile agent data integrity protection.
Yang, Y., Guan, SU, Yang, Y, Guan, S.-U.
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

SoK: Dlog-based Distributed Key Generation [PDF]

open access: yes
Distributed Key Generation (DKG) protocols are fundamental components of threshold cryptography, enabling key generation in a trustless manner for a range of cryptographic operations such as threshold encryption and signing.
Renas Bacho, Alireza Kavousi
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

On the security of software-defined next-generation cellular networks

open access: yes, 2016
In the recent years, mobile cellular networks are ndergoing fundamental changes and many established concepts are being revisited. Future 5G network architectures will be designed to employ a wide range of new and emerging technologies such as Software ...
Vasilakis, Vasileios   +4 more
core  

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