Results 71 to 80 of about 6,075,042 (257)

Temporal Interference Stimulation of Centromedian‐Parafascicular Complex in Disorders of Consciousness: A Pilot Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Treatment of disorders of consciousness (DoC) remains a major clinical challenge, and noninvasive, targeted modulation of deep brain structures has emerged as a promising therapeutic strategy. We aimed to evaluate the feasibility/safety and preliminary effects of thalamic temporal interference stimulation (TIS) targeting centromedian‐
Gengyao Hu   +7 more
wiley   +1 more source

Supporting energy technology deployment while avoiding unintended technological lock-in: a policy design perspective

open access: yesEnvironmental Research Letters, 2018
Technology deployment policies can play a key role in bringing early-stage energy technologies to the market and reducing their cost along their learning curves.
Leonore Haelg   +2 more
doaj   +1 more source

Lock and key micelles

open access: yes, 2000
A lock unimolecular micelle includes at least one engineered acceptor specifically binding a ligand (or specifically a key unimolecular micelle) thereto.
Baker, Gregory   +2 more
core  

Impact of Age on the Diagnostic Yield of Routine EEG in People With Childhood or Juvenile Absence Epilepsy: A Cross‐Sectional Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background We aimed to identify the proportion of individuals with a confirmed diagnosis of childhood absence epilepsy (CAE) or juvenile absence epilepsy (JAE) who show a negative routine EEG (rEEG), and to determine the main factors associated with this finding.
Francesco Fortunato   +7 more
wiley   +1 more source

The Lock is the Key: Development of Novel Drugs through Receptor Based Combinatorial Chemistry

open access: yesActa Chimica Slovenica, 2017
Modern drug discovery is mainly based on the de novo synthesis of a large number of compounds with a diversity of chemical functionalities. Though the introduction of combinatorial chemistry enabled the preparation of large libraries of compounds from so-
Goran Šinko, Nikola Maraković
doaj   +1 more source

The final step of 40S ribosomal subunit maturation is controlled by a dual key lock. [PDF]

open access: yesElife, 2021
Plassart L   +12 more
europepmc   +1 more source

Lock-In Agreements in Venture Capital Backed UK IPOs [PDF]

open access: yes
This paper examines the impact of venture-capital backing of UK companies issuing shares at flotation on the characteristics of the lock-in agreements entered into by the existing shareholders, and on the abnormal returns realised around the expiry of ...
Khurshed, A.   +3 more
core  

Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley   +1 more source

Is cholesterol both the lock and key to abnormal transmembrane signals in Autism Spectrum Disorder?

open access: yesLipids in Health and Disease
Disturbances in cholesterol homeostasis have been associated with ASD. Lipid rafts are central in many transmembrane signaling pathways (including mTOR) and changes in raft cholesterol content affect their order function.
Clifford Lingwood
doaj   +1 more source

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