Results 71 to 80 of about 74,857 (266)

Risk of Retinopathy Associated with Long‐Term Use of Hydroxychloroquine in Patients with Rheumatic Diseases: A Systematic Review and Meta‐Analysis

open access: yesArthritis Care &Research, EarlyView.
Objective We aimed to estimate the prevalence and cumulative incidence of hydroxychloroquine retinopathy (HCQ‐R) and its risk factors among patients receiving long‐term HCQ with rheumatic diseases through a systematic review and meta‐analysis of observational studies that used spectral‐domain optical coherence tomography (SD‐OCT) for screening ...
Narsis Daftarian   +4 more
wiley   +1 more source

Clinical Significance of Therapeutic Drug Level Monitoring for Mycophenolate in Patients With Extrarenal Systemic Lupus Erythematosus—A Systematic Review and Meta‐Analysis

open access: yesArthritis Care &Research, EarlyView.
Objective Clinical response to mycophenolic acid (MPA) is highly heterogeneous; thus, therapeutic drug level monitoring (TDM) may help improve treatment efficacy. This systematic review and meta‐analysis examined therapeutic ranges for MPA levels associated with better outcomes and safety in patients with systemic lupus erythematosus (SLE ...
Zahraa Qamhieh   +5 more
wiley   +1 more source

The Lock is the Key: Development of Novel Drugs through Receptor Based Combinatorial Chemistry

open access: yesActa Chimica Slovenica, 2017
Modern drug discovery is mainly based on the de novo synthesis of a large number of compounds with a diversity of chemical functionalities. Though the introduction of combinatorial chemistry enabled the preparation of large libraries of compounds from so-
Goran Šinko, Nikola Maraković
doaj   +1 more source

The final step of 40S ribosomal subunit maturation is controlled by a dual key lock. [PDF]

open access: yesElife, 2021
Plassart L   +12 more
europepmc   +1 more source

The Lupus Damage Index Revision Program: Results From the Item Generation and Reduction Phases

open access: yesArthritis Care &Research, EarlyView.
Objective A data‐driven and expert/patient consensus‐based project to develop a revised Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) Damage Index (SDI) is under way supported by SLICC, ACR, and the Lupus Foundation of America. Our objective is to report the item generation and reduction phase results
Burak Kundakci   +25 more
wiley   +1 more source

Exploring Topsnut-Graphical Passwords by Twin Odd-elegant Trees

open access: yesMATEC Web of Conferences, 2017
Graphical passwords are facing a good opportunity as 2-dimension codes are accepted by many people, since it has been applied in mobile devices, electronic equipments with touch screen, and so on.
Wang Hong-yu, Xu Jin, Yao Bing
doaj   +1 more source

Design of an Open-Source Decoder for Educational Escape Rooms

open access: yesIEEE Access, 2019
Escape rooms are a popular recreational activity which involves solving a series of puzzles within a time limit to `escape' the fictional setting they are in. As a fun, collaborative learning activity, escape rooms are increasingly finding their way into
Robert Ross
doaj   +1 more source

The locks and keys to industrial biotechnology

open access: yesNew Biotechnology, 2009
The sustainable use of resources by Nature to synthesize the required products at the right place, when they are needed, continues to be the role model for total synthesis and production in general. The combination of molecular and engineering science and technology in the biotechnological approach needs no protecting groups at all and has therefore ...
openaire   +2 more sources

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