Results 51 to 60 of about 597,682 (300)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Silences in the boom: coal seam gas, neoliberalizing discourse, and the future of regional Australia
Journal of Political Ecology, 2014 In high-stakes resource use struggles currently playing out across the world, different beliefs about economics and "growth-first" regional development underpin decisions and dynamics that have far-reaching consequences.
Alexandra Mercer +2 more
doaj +1 more source
Health Care Coverage: Job Lock and the Potential Impact of the Patient Protection and Affordable Care Act [PDF]
, 2011 [Excerpt] The majority of Americans—about 55 percent in 2010—rely on employer-sponsored health care coverage, which is largely subsidized by most employers and thus less costly to employees than coverage purchased by individuals on their own.
United States Government Accountability Office
core +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Opening up public data should be an urgent priority for the government and could lead to considerable economic benefits [PDF]
, 2012 There is no longer a reasonable justification for keeping publicly funded data under lock and key. With the government ostensibly committed to transparency, Chris Yiu argues that opening up public data is a must, and could have solid economic and ...
Yiu, Chris
core
From Popular Culture to Popular Custom, and Back Again : A love-lock's tale [PDF]
, 2019 Walk over a major bridge in a Western city and chances are you will come across at least one or two love-locks. These are padlocks inscribed with names or initials and attached to a public structure, typically by a couple in declaration of romantic ...
Houlbrook, Ceri
core +3 more sources
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Lessons from Love-Locks: The archaeology of a contemporary assemblage [PDF]
, 2017 This document is the Accepted Manuscript version. The final, definitive version of this paper has been published in Journal of Material Culture, November 2017, published by SAGE Publishing, All rights reserved.Loss of context is a challenge, if not the ...
Bord J +31 more
core +2 more sources
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Portable appliance security apparatus [PDF]
, 1981 An apparatus for securing a small computer, or other portable appliance, against theft is described. It is comprised of a case having an open back through which the computer is installed or removed. Guide members in the form of slots are formed in a rear
Kerley, J. J.
core +1 more source