Results 81 to 90 of about 594,656 (344)

Sarilumab in Polyarticular‐Course Juvenile Idiopathic Arthritis: Dose‐Finding and One‐Year Analysis of a Phase 2b, Open‐Label, Multicenter Study

Arthritis Care &Research, Accepted Article.
Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension‐phase). During part 1, three doses were assessed in two weight groups (Group A/B: ≥30–60 kg/≥10–<
Fabrizio De Benedetti, Inmaculada C. Penadés, Irina Nikishina, Ivan Foeldvari, Alberto J. Spindler, Anna Kozlova, Nadina Rubio‐Pérez, Pierre Quartier, Zbigniew Żuber, Raul Barria, Daniel Clemente, Gabriel V. Cornejo, Katherine Marzan, Nancy Liu, Christine Xu, Stephen DiMartino, Angeliki Giannelou, Fei Cao‐Ghoul, Bolanle Akinlade, Lydie Baret‐Cormel   +19 more
wiley   +1 more source

Mechanochemical Synthesis and Characterization of Nanostructured ErB4 and NdB4 Rare‐Earth Tetraborides

Advanced Engineering Materials, Volume 27, Issue 6, March 2025.
ErB4 and NdB4 nanostructured powders are produced by mechanochemical synthesis. 5 h mechanical alloying and 4 M HCl acid leaching are used in the production. ErB4 and NdB4 powders exhibit maximum magnetization of 0.4726 emu g−1 accompanied with an antiferromagnetic‐to‐paramagnetic phase transition at about TN = 18 K and 0.132 emu g−1 with a maximum at ...
Burçak Boztemur, Faruk Kaya, Bora Derin, Mustafa Lütfi Öveçoğlu, Ju Li, Duygu Ağaoğulları   +5 more
wiley   +1 more source

Is cholesterol both the lock and key to abnormal transmembrane signals in Autism Spectrum Disorder?

Lipids in Health and Disease
Disturbances in cholesterol homeostasis have been associated with ASD. Lipid rafts are central in many transmembrane signaling pathways (including mTOR) and changes in raft cholesterol content affect their order function.
Clifford Lingwood
doaj   +1 more source

Bistable Mechanisms 3D Printing for Mechanically Programmable Vibration Control

Advanced Engineering Materials, EarlyView.
This work introduces a 3D‐printed bistable mechanism integrated into tuned mass dampers (TMDs) for mechanically adaptive passive vibration suppression. Through optimized geometry, the bistable design provides adaptable vibration reduction across a broad range of scenarios, achieving effective vibration mitigation without complex controls or external ...
Ali Zolfagharian, Frédéric Demoly, Mohammad Lakhi, Bernard Rolfe, Mahdi Bodaghi   +4 more
wiley   +1 more source

ALL-MASK: A Reconfigurable Logic Locking Method for Multicore Architecture with Sequential-Instruction-Oriented Key [PDF]

, 2022
Jianfeng Wang, Zhonghao Chen, Jiahao Zhang, Yixin Xu, Tongguang Yu, Enze Ye, Ziheng Zheng, Huazhong Yang, Sumitha George, Yongpan Liu, Vijaykrishnan Narayanan, Xueqing Li   +11 more
openalex   +1 more source

Solvent fluctuations induce non-Markovian kinetics in hydrophobic pocket-ligand binding

, 2016
We investigate the impact of water fluctuations on the key-lock association kinetics of a hydrophobic ligand (key) binding to a hydrophobic pocket (lock) by means of a minimalistic stochastic model system.
Dzubiella, Joachim, Setny, Piotr, Weiß, R. Gregor   +2 more
core   +1 more source

Supporting energy technology deployment while avoiding unintended technological lock-in: a policy design perspective

Environmental Research Letters, 2018
Technology deployment policies can play a key role in bringing early-stage energy technologies to the market and reducing their cost along their learning curves.
Leonore Haelg, Marius Waelchli, Tobias S Schmidt   +2 more
doaj   +1 more source

Trace Nickel Activated Biphasic Core‐CuOii/Shell‐CuOi Secondary Microspheres Enable Room Temperature Parts‐Per‐Trillion‐Level NO2 Detection

Advanced Engineering Materials, EarlyView.
An idea of designing novel sensors is proposed by creating appropriate Schottky barriers and vacancies between isomorphous Core‐CuOii/ Shell‐CuOi secondary microspheres and enhancing catalytic and spill‐over effects, and electronegativity via spontaneous biphasic separation, self‐assembly, and trace‐Ni‐doping.
Bala Ismail Adamu, Peipei Chen, Shafia Mukhtar Ibrahim, Mukhtar Lawan Adam, Attia Falak, Mokhotjwa Simon Dhlamini, Hanfu Wang, Lingxiang Jiang, Weiguo Chu   +8 more
wiley   +1 more source

Multi-order analytical solving computation of rainstorm causal decomposition during typhoons using a designed key-lock quasi-Newton optimizing derivation. [PDF]

Heliyon, 2023
Huang CL, Hsu NS, Yao CH, Lo WC.
europepmc   +1 more source

Design of an Open-Source Decoder for Educational Escape Rooms

IEEE Access, 2019
Escape rooms are a popular recreational activity which involves solving a series of puzzles within a time limit to `escape' the fictional setting they are in. As a fun, collaborative learning activity, escape rooms are increasingly finding their way into
Robert Ross
doaj   +1 more source