Results 151 to 160 of about 6,477,960 (317)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Institutionalising Performance Management in R&D Organisations: Key Concepts and Aspects [PDF]

open access: yes
In an era in which accountability, cost effectiveness and impact orientation are at premium, Research and Technological Organisations are under pressure not only to improve their performance but also to be able to demonstrate this improvement.
Sutherland, Alistair J.   +1 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga   +2 more
wiley   +1 more source

Distributed Key Management to Secure IoT Wireless Sensor Networks in Smart-Agro. [PDF]

open access: yesSensors (Basel), 2020
Mawlood Hussein S   +2 more
europepmc   +1 more source

Singularity Blockchain Key Management via non-custodial key management

open access: yes
web3 wallets are key to managing user identity on blockchain. The main purpose of a web3 wallet application is to manage the private key for the user and provide an interface to interact with the blockchain. The key management scheme ( KMS ) used by the wallet to store and recover the private key can be either custodial, where the keys are permissioned
openaire   +2 more sources

Aspects of career development and information management policies at the Bank of Japan - a frank interview with a former central banker

open access: yes, 2004
Relatively little empirical research has been published on the internal affairs of central banks. Secrecy is a key aspect of central banking, and this has posed a major obstacle to researchers.
Werner, R.A.
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

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