Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
A WSN Layer-Cluster Key Management Scheme Based on Quadratic Polynomial and Lagrange Interpolation Polynomial. [PDF]
Sensors (Basel), 2020 Wang X, Yang Z, Feng Z, Zhao J.
europepmc +1 more source
Improvement and Implementation of Sustainable Key Performance Indicators in Supply Chain Management: The Case of a Furniture Firm [PDF]
, 2023 Yüksel Yurtay +4 more
openalex +1 more source
POLICY IMPLICATIONS ON THE REDUCTION OF NITROGEN FERTILIZER USE ON NON-IRRIGATED CORN-WINTER WHEAT PRODUCTION IN NORTH ALABAMA [PDF]
Environmental and economic effects of nitrogen fertilizer reduction on North Alabama small farms are evaluated using GPFARM. GPFARM incorporates climate, soil data and management practices to simulate science and economic analysis for a farm/ranch ...
Befecadu, Joseph +2 more
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Multi Dimensional and Scenario Generalization Value Quantification of Data Assets Based on a Multi Factor Valuation Scoring Model -- Taking the Water Resources Data Assets of Key Provinces in the Comprehensive Management of the Yangtze River Basin as an Example [PDF]
Fu Rao
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Maintenance Management through Intelligent Asset Management Platforms (IAMP). Emerging Factors, Key Impact Areas and Data Models [PDF]
, 2020 Adolfo Crespo Márquez +3 more
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Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source