Results 41 to 50 of about 1,483,664 (290)
Molecular Oncology, EarlyView.There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes +20 more
wiley +1 more source
Security for 5G Mobile Wireless Networks
IEEE Access, 2018 The advanced features of 5G mobile wireless network systems yield new security requirements and challenges. This paper presents a comprehensive study on the security of 5G wireless network systems compared with the traditional cellular networks.
Dongfeng Fang, Yi Qian, Rose Qingyang Hu
doaj +1 more source
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Secure Session Key Management Scheme for Meter-Reading System Based on LoRa Technology
IEEE Access, 2018 Long range (LoRa) technology is a wireless communication technology, which may provide low-power, low-rate, and LoRa communication. It may widely be used into many applications, such as smart metering and factory monitoring.
Zhuoqun Xia +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
Key Management Systems at the Cloud Scale
Cryptography, 2019 This paper describes a cloud-scale encryption system. It discusses the constraints that shaped the design of Amazon Web Services’ Key Management Service, and in particular, the challenges that arise from using a standard mode of operation such as ...
Matthew Campagna, Shay Gueron
doaj +1 more source
Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
VERIFICATION OF KEY MANAGEMENT CRYPTOGRAPHIC PROTOCOLS WITH COLORED PETRI NETS
Вестник Донского государственного технического университета, 2018 The possibility of using colored Petri nets for the analysis of key distribution cryptographic protocols as an example of symmetric Needham—Schroeder protocol is reviewed and evaluated.
Nadezhda S. Mogilevskaya +1 more
doaj