Results 81 to 90 of about 181,059 (277)

Study on the Mechanism of Intense Strata Behavior and Control Technology for Goaf-Side Roadway in Extra-Thick Coal Seam

Applied Sciences
With the depletion of shallow coal resources, deep extra-thick coal seam mining has become vital for energy security, yet fully mechanized top-coal caving (FMTC) goaf-side roadways face severe challenges of excessive advanced deformation and intense ...
Shuai Yan, Yongjie Wang, Jianbiao Bai, Xiaolin Li, Qundi Qu   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A novel short‐wall caving zone backfilling technique for controlling mining subsidence

Energy Science & Engineering, 2019
Mining‐induced voids are the main circulation pathways for underground fluids such as water and coalbed methane. The collapse of these voids transmits to the ground surface, resulting in subsidence and building collapse.
Wenbing Liu, Jingmin Xu, Weibing Zhu, Sihua Wang   +3 more
doaj   +1 more source

Development path and key technology analysis of shaft and tunnel construction in deep stratum with high temperature

工程科学学报, 2022
The joint exploitation of deep mineral and geothermal resources strategy provides an effective way to realize the economic exploitation of “resources-thermal” and achieve a win-win situation. The technology for deep high-temperature stratum shaft and roadway construction is an important support and guarantee for the safe and efficient implementation of
Zhi-qiang LIU, Xiang-sheng CHEN, Zhao-yang SONG, Shou-ye CHENG   +3 more
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Thurston's pullback map on the augmented Teichm\"uller space and applications

, 2011
Let $f$ be a postcritically finite branched self-cover of a 2-dimensional topological sphere. Such a map induces an analytic self-map $\sigma_f$ of a finite-dimensional Teichm\"uller space.
A. Douady, A. Katok, C.T. McMullen, H. Masur, J. Milnor, J.H. Hubbard, K.M. Pilgrim, K.M. Pilgrim, L. Ahlfors, L. Bers, L. Bers, N. Selinger, Nikita Selinger, S.A. Wolpert, S.A. Wolpert, W. Abikoff, W.P. Thurston, X. Buff, Y. Imayoshi   +18 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Disaster-inducing mechanism of the movement of high-position combination cantilever plate structures in non-uniform and extra-thick coal seam mining

Gong-kuang zidonghua
The mining of non-uniform and extra-thick coal seams significantly affects the roof breaking structure in the mining field, which greatly impacts the mining pressure behavior in the working face.
ZHU Weibing, GUO Chunlei, LUO Xun, CHAI Faying, XIE Jianlin, CHAI Yi   +5 more
doaj   +1 more source

Linear manifolds in the moduli space of one-forms

, 2007
We study closures of GL_2(R)-orbits on the total space of the Hodge bundle over the moduli space of curves under the assumption that they are algebraic manifolds.
Moeller, Martin
core   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source