Results 231 to 240 of about 1,145,786 (286)

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

Evaluating the Association of Ki-67 with Oncotype DX Recurrence Score in Early-Stage ER-Positive/HER2-Negative Breast Cancer. [PDF]

Cancers (Basel)
Dragoumis D, Kapetsis G, Louis K, Maniatis D, Mpalampou E, Bouloukos K, Xenakis X, Papaioannou N, Parpoudi S, Pesmatzoglou G, Sachoulidou A, Sfakianakis E, Triantafyllidou S, Tsantilas V, Tsiftsoglou A, Filippidou S, Fyssas IP, Stathoulopoulou M, Matiatou M, Karathanasis P, Alexandrou D, Amanatidou A, Desiris K, Efraimidou E, Zavos A, Michailidou E, Roussogiannis S, Venizelos V.   +27 more
europepmc   +1 more source

REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma

Advanced Science, EarlyView.
Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu, Shihui Shen, Dongxia Li, Peilin Shi, Jiaming Xu, Tongxin Lv, Yingying Du, Jingwei Zhang, Bo Yang, Hansen Chen, Zhuoya Peng, Wenjie Ren, Lu Zhang, Sheng Cheng, Tongjin Yin, Wencai Sheng, Lei Li, Juan Wu, Qingcheng Yang, Shuogui Xu, Wei Zheng   +20 more
wiley   +1 more source

CT-Based Radiomics for Non-Invasive Prediction of Ki-67 Expression in Hepatocellular Carcinoma. [PDF]

J Hepatocell Carcinoma
Wu M, Du Z, Xiao Y, Wang Y, Yang J, Li Z, Liu X, Yang S, An T.   +8 more
europepmc   +1 more source

Single‐Cell Profiling Identifies SLC2A5‐Mediated Fructose Metabolism as a Vulnerability in Primary CNS Lymphoma

Advanced Science, EarlyView.
Glucose deprivation in the primary CNS lymphoma (PCNSL) tumor microenvironment drives SLC2A5 (encoding GLUT5)‐dependent fructose metabolism in tumor cells, while hypoxia induces HIF‐mediated SLC2A5 expression in tumor‐supportive macrophages, revealing SLC2A5‐driven fructose utilization as a shared and targetable metabolic vulnerability across malignant
Qiaoli Wu, Qianru Zhang, Wenqiang Yan, Lu Sun, Yiran Cui, Bolin Liu, Guoqing Han, Feng Zhang, Ke Pu, Mingchao Zhang, Xiaobing Zhang, Qingguo Li, Gang An, Yuxuan Liu   +13 more
wiley   +1 more source

The Ki-67 proliferation index and recurrence risk of intracranial meningioma: a multicenter, retrospective cohort study of 5,050 patients. [PDF]

Acta Neurochir (Wien)
Mirian C, Jensen LR, Juratli TA, Maier AD, Broechner A, Torp SH, Shih HA, Morshed RA, Young JS, Magill ST, Bertero L, Stummer W, Spille DC, Brokinkel B, Oya S, Miyawaki S, Saito N, Proescholdt M, Kuroi Y, Gousias K, Simon M, Moliterno J, Prat-Acin R, Goutagny S, Prabhu VC, Tsiang JT, Wach J, Güresir E, Yamamoto J, Kim YZ, Lee JH, Kim DW, Koshy M, Perumal K, Baskaya MK, Cannon DM, Shrieve DC, Suh CO, Chang JH, Kamenova M, Straumann S, Soleman J, Eyüpoglu IY, Catalan T, Lui A, Theodosopoulos PV, McDermott MW, Wang F, Góes P, Jamshidi A, Komotar R, Ivan M, Luther E, Souhami L, Guiot MC, Csonka T, Endo T, Barrett OC, Jensen R, Gupta T, Patel AJ, Klisch TJ, Kim JW, Maiuri F, Barresi V, Tabernero MD, Skyrman S, Law I, Scheie D, Kristensen BW, Munch TN, Meling T, Fugleholm K, Blanche P, Mathiesen T.   +74 more
europepmc   +1 more source

Interfacial Growth of 420 nm Ultrathin and Dense MOFs for Composite Electrolyte to Reduce Li+ Conduction Resistance and Inhibit Lithium Dendrite

Advanced Science, EarlyView.
In this work, an interfacial growth method using PVDF‐HFP enables controlled permeation of 2‐methylimidazole to react with Co2+, forming an ultrathin (420 nm) ZIF‐67 layer by precisely tuning the reaction time. This dense layer promotes lithium salt dissociation and suppresses dendrite growth, while its ultrathin nature reduces Li+ transport resistance,
Xinhong Qi, Zhaokai Rui, Shichen Zhang, Yihang Li, Ziyi Xin, Mengjuan Li, Lu Gao, Yuchen He, Xiaobin Jiang, Xiangcun Li, Gaohong He   +10 more
wiley   +1 more source

Immunohistochemical Evaluation of Ki-67 Proliferation Marker in Various Biological Variants of Ameloblastoma. [PDF]

Cureus
Salunkhe G, Issac AS, Jha R, Kolte D, Datla PP, Tiwari RV, Dixit H, Gupta S.   +7 more
europepmc   +1 more source

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source