Results 101 to 110 of about 94,068 (259)
Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress
Advanced Science, EarlyView.Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen +11 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo +16 more
wiley +1 more source
Pancreatic Atrophy: A Narrative Review and Surgical Interpretation
Annals of Gastroenterological Surgery, EarlyView.Pancreatic parenchymal atrophy pattern and intraoperative margin assessment guide surgical strategy. ABSTRACT Despite recent advances in multimodal management, pancreatic ductal adenocarcinoma remains a fatal malignancy. Early detection of indirect findings of pancreatic ductal adenocarcinoma is essential to improve treatment outcomes, drawing ...
Rika Fujino +4 more
wiley +1 more source
KI-67 IMMUNOHISTOHEMICAL EXPRESSION IN PROSTATIC LESIONS
The Iraqi Journal of Medical Sciences, 2017 Background: The cell proliferation marker, ki-67, is a nuclear and nucleolar protein, which can be detected during all active phases of the cell cycle (G1, S, G2, and mitosis), but absent from cell resting phases.
Inas A. Rasheed +2 more
doaj +2 more sources
American Journal of Hematology, EarlyView.ABSTRACT CD19‐directed chimeric antigen receptor (CAR) T‐cell therapy has transformed outcomes for patients with relapsed or refractory (r/r) mantle cell lymphoma (MCL), yet more than 40% relapse within one year. Early identification of patients at risk for progression could inform post CAR‐T surveillance and consolidation strategies.
Snegha Ananth +12 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley +1 more source
Pakistan Journal of Medicine and DentistryBackground: Identification of cells in the replicative pool for cases of breast cancers and their association with various conventional prognostic parameters would have widespread predictive as well as therapeutic value.
M Mohiuddin Alamgir, Saeeda Baig
doaj
The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding
Animal Research and One Health, EarlyView.A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang +10 more
wiley +1 more source
Animal Research and One Health, EarlyView.Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu +8 more
wiley +1 more source
Сибирский онкологический журнал, 2016 Purpose: to study argyrophilic proteins associated with nucleolar organizer regions (Ag-NOR proteins) in proliferating cells in relationship between the clinical and morphological parameters and survival in squamous cell lung carcinoma.
D. S. Kobyakov +3 more
doaj