Results 31 to 40 of about 2,542,347 (220)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
smartCasaplus – ein risikobasiertes geriatrisches Gesundheitscoaching für multimorbide Versicherte
Monitor VersorgungsforschungDas geriatrische Schulungsprogramm Casaplus der MedicalContact AG bietet bereits seit 2007 telefonische Gesundheitscoachings für multimorbide geriatrische Versicherte, von dem bereits ca. 30.000 Versicherte profitiert haben.
Prof. Dr. rer. pol. Stephan Burger +2 more
doaj +1 more source
Relationships and implications for complementary and alternative medicine in Aotearoa New Zealand: A discussion paper [PDF]
, 2019 The purpose of this paper is to initiate a discussion on contextualising the relationship between the nursing profession and complementary and alternative medicine (CAM) within Aotearoa New Zealand.
Te Huia, Maria
core
, 2018 This work investigates the dynamics of a one-dimensional homogeneous harmonic chain on a horizontal table. One end is anchored to a wall, the other (free) end is pulled by external force.
Baek, Seung Ki
core +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Plant Production Science, 2019 Shea tree (Vitellaria paradoxa) is one of the main native oil plants with high economic value in Africa. Its fruits are used for food, medicinal, cultural and exportation purposes. However, the lack of efficient tools to assess annual fruit production of
Loyapin Bondé +4 more
doaj +1 more source
Engagement politique des femmes et logiques d’incorporation dans les instances de décision dans la ville de Ouagadougou (Burkina Faso) [PDF]
Pensées Genre, Penser Autrement, 2022 La participation effective des femmes à la vie politique burkinabè est faible et stagnante. Cependant, une catégorie de femmes engagées sont parvenues à tirer leur épingle du jeu.
Sophie Wenninkonté KABRE +1 more
doaj
On the use of crude eigenvalue bounds in the solution of robbin's problems [PDF]
, 1973 In this paper we consider what effect the use of crude eigenvalue estimates, for the evaluation of the iterative parameters, has on the convergence of the A.D.I.
Iordandis, KI
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source