Results 41 to 50 of about 2,547,482 (267)

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

La caricature des démocraties africaines avant et après la baule dans le parachutage et en attendant le vote des bêtes sauvages. [PDF]

Pensées Genre, Penser Autrement, 2022
Cette réflexion porte sur la présence d’éléments de l’histoire politique de l’Afrique francophone dans la fiction romanesque. Par le truchement de la colonisation, l’Afrique occidentale française (AOF) a épousé des valeurs de son ancien maitre ...
Boulkini COULDIATI, Fatimata NOMBRE
doaj  

Ki adná a veséjét, és ki nem?

Orvosi Hetilap, 2022
Bevezetés:Napjainkban az élő donorral történő szervtranszplantáció egyre gyakrabban végzett egészségügyi beavatkozás. Az élő szervdonáció az egészségügyi kérdéseken túl számos pszichoszociális kérdést felvet az adományozókkal és motivációjukkal kapcsolatban.Célkitűzés:Az élő vesedonációhoz fűződő attitűd, ismeretek, hiedelmek feltárása és az ...
Chrisztó, Zita, Urbán, Róbert, Rigó, Adrien   +2 more
openaire   +2 more sources

Role of vertex corrections in the $T$-linear resistivity at the Kondo breakdown quantum critical point

, 2011
The Kondo breakdown scenario has been claimed to allow the $T$-linear resistivity in the vicinity of the Kondo breakdown quantum critical point, two cornerstones of which are the dynamical exponent $z = 3$ quantum criticality for hybridization ...
Kim, Ki-Seok
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

A NEW APPROACH TO DISINFECTION OF CLEANROOMS (MICROBIOLOGICALLY ASPECTS)

Разработка и регистрация лекарственных средств, 2019
Microbiological studies conducted the effectiveness of surfaces decontamination by using potassium iodide submicron aerosol, made by the device Generator of sea air «Aeroiodine». We used bacteria of the genus Staphylococcus as the test cultures.
N. P. Sachivkina
doaj  

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

THE EFFICACY OF ZUCLOPENTHIXOL ACETATE IN PSYCHOTIC PATIENTS

Psychiatry and Clinical Psychopharmacology, 2021
Fourteen psychotic patients, 7 acute manic and 7 exacerbated patients were included in the study to evaluate the clinical effect of zuclopenthixol acetate in viscoleo. Each patient received 50-200mg. of the drug for the first injection. If necessary the
Nesrin DlLBAZ, Hatice GÜZ, Göksel BAYAM   +2 more
doaj  

Te Aroha o te Hauangiangi : Māori perspectives on healing from substance abuse : a thesis presented in partial fulfilment of the requirements for the degree of Master of Philosophy in Māori Studies at Te Pūtahi-ā-Toi School of Māori Studies, Massey University, Palmerston North, Aotearoa/New Zealand [PDF]

, 2006
This thesis examines and describes Māori cultural components used in the treatment of substance abuse problems in the Taha Māori Programme at Queen Mary Hospital.
Warbrick, Keremete Te Rangimaria
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