Results 151 to 160 of about 123,308 (219)

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

Advanced Science, EarlyView.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang, Yujing Shi, Zehua Gao, Jing Wang, Changsheng Liu   +4 more
wiley   +1 more source

Menopausal timing and senescent-immune coupling in age-related lobular involution of the human breast: a longitudinal cohort study. [PDF]

EBioMedicine
Lue JC, Stallings-Mann M, Hoskin T, McCauley BM, Vierkant RA, Pacheco-Spann L, Fischer JL, Gehling DL, Seymour LR, Baker DJ, Degnim AC, Winham SJ, Sherman ME, Radisky DC.   +13 more
europepmc   +1 more source

A Cascaded DNA Nanocircuit for Multi‐Signal‐Responsive Precision siRNA Delivery in Cancer Therapy

Advanced Science, EarlyView.
A cascaded dual‐AND logic DNA nanocircuit is engineered to respond to three tumor‐specific signals in a sequential manner: extracellular acidic pH, membrane‐overexpressed nucleolin (NCL), and intracellular glutathione (GSH). This programmable system selectively releases siPARP1 in glioblastoma (GBM), effectively silencing PARP1 and reversing TMZ ...
Yan Zhao, Yufei Lan, Min‐Goo Lee, Jinjun He, Yueran Pan, Eunji Kim, Xin Fu, Sungwook Jung, Wanxia Lu, Jinyue Fan, Haoxiang Chen, Yuanbo Zhao, Yuling Xu, Jong Seung Kim, Chao Zhang   +14 more
wiley   +1 more source

Optimized air-liquid interface cultivation enhances survival and integrity of mouse colon precision-cut tissue slices. [PDF]

Sci Rep
Thalheim D, Knittel J, Erlenbach-Wuensch K, Nagy R, Tietze R, Hartmann A, Schneider-Stock R.   +6 more
europepmc   +1 more source

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer

Advanced Science, EarlyView.
Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng, Chaoying Wei, Zhitong Niu, Jinxin Chen, Guojie Long, Yingzhen Weng, Qiufeng Liu, Yue Jiang, Panpan Wang, Ronghua Zhang, Qiang Yu, Xiaojian Wu, Wenyu Wang   +12 more
wiley   +1 more source

Malignant Odontogenic Tumors: A Clinicopathological Study of 53 Cases in Brazil. [PDF]

Head Neck Pathol
Paula de Paula L, Pontes FSC, Fonseca FP, Vargas PA, Lopes MA, Dos Santos Silva AR, Júnior JJ, Penafort PVM, Mosqueda-Taylor A, da Silva Santos PS, Lara VS, Soares CT, Dos Santos Pinto Júnior D, Ribeiro R, de Mendonça EF, Arantes DAC, Vencio EF, de Jesus Costa IFV, de Aquino Xavier FC, Dos Santos JN, Gondak R, Siqueira FM, Schussel JL, de Lima HG, Soares CD, Pontes HAR.   +25 more
europepmc   +1 more source

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

Advanced Science, EarlyView.
ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu, Wanying Xiang, Xinyue Wang, Yue Pan, Jing Gao, Jiezhen Yang, Yufei Wang, Zhipu Zhu, Man Tong, Lei Jin, Yan Ye   +10 more
wiley   +1 more source

Noninvasive prediction of Ki67 proliferation index in breast cancer based on integrated photoacoustic imaging. [PDF]

BMC Med Imaging
Mo S, Wang M, Li G, Tian H, Wu H, Tang S, Zou X, Shao M, Xu J, Huang Z, Dong F.   +10 more
europepmc   +1 more source

Corynoxine Inhibits Tumor Growth via Targeting NQO1 and Modulating the PTPA–NQO1/PP2A Switch to Activate PP2A

Advanced Science, EarlyView.
Corynoxine exerts potent broad‐spectrum anticancer activity by directly targeting NQO1. This interaction dissociates the oncogenic NQO1‐PTPA complex, releasing PTPA to robustly activate the tumor suppressor PP2A. Consequently, downstream Raf/MEK/ERK and PI3K/AKT signaling pathways are suppressed, downregulating c‐Myc and driving tumor regression ...
Guoqing Hou, Li Lin, Mengjie Xia, Ruohan Liang, Yueyue Zhang, Linna Du, Xuan Cao   +6 more
wiley   +1 more source

<i>MKI67</i> Enrichment Characterizes a Proliferative and Genomically Unstable Phenotype in Pancreatic Ductal Adenocarcinoma. [PDF]

Cancers (Basel)
Seavey CN, Kawashima K, Khan A, Di Lena É, Takabe K, Dhir M.   +5 more
europepmc   +1 more source