Results 181 to 190 of about 177,505 (309)

Contribution of Mesenchymal-like and Epithelial Cellular Subsets to Chemotherapy Resistance in Triple-Negative Breast Cancer. [PDF]

Int J Mol Sci
Vuong NB, Korolkova OY, Izban MG, Sakwe NI, McIntosh AR, Ball DD, Black PJ, Edwards AD, Ballard BR, Adunyah SE, Sakwe AM.   +10 more
europepmc   +1 more source

Depletion of p75NTR in Schwann Cells Driven by Inflammation Mediates Cutaneous Pain in Psoriasis

Advanced Science, EarlyView.
Psoriasis‐like inflammation induces proliferation and molecular remodeling of cutaneous Schwann cells, marked by reduced p75NTR and increased NGF expression. IL‐17A promotes this process, whereas Schwann cell‐specific p75NTR overexpression alleviates cutaneous pain in vivo.
Yibo Wang, Linlin Xu, Chenglong Pan, Ruonan Cao, Piao Zeng, Xinxing Lyu, Qingxia Hu, Zhenzhen Yan, Shuhong Huang, Ningning Dang   +9 more
wiley   +1 more source

Informative High-Risk HPV Genotyping in Cervical Cancer Screening: Integrated Analysis of Cytology and p16/Ki67 Dual Staining. [PDF]

Cancers (Basel)
Trzeszcz M, Mazurec K, Mazurec M, Kobierzycki C, Halon A, Jach R.   +5 more
europepmc   +1 more source

Early Detection and Inhibition of Post‐Surgical Cancer Recurrence by Synthetic Extracellular Vesicles

Advanced Science, EarlyView.
An implantable hydrogel is designed to hold gene transfection agents engineered to turn early recurrent tumor cells into generators of synthetic EVs. These synthetic EVs can express engineered miR‐26a (E‐miR‐26a) for highly sensitive detection and PD‐1 (a PD‐L1‐blocking agent) for therapeutic intervention, thereby enabling early detection and ...
Junli Zhang, Wenjia Chang, Ruolin Hu, Peiyan Su, Qin Zhou, Yanan Li, Zhenzhong Zhang, Kaixiang Zhang   +7 more
wiley   +1 more source

Role of HER2 in Response to Neoadjuvant Endocrine Therapy in Luminal Breast Cancer. [PDF]

Curr Oncol
Monte CD, Martí C, Rodríguez E, Moreno-Palacios E, Frías L, Meléndez M, Loayza A, Yébenes L, Sánchez-Méndez JI.   +8 more
europepmc   +1 more source

Nano‐Enabled Systemic Delivery of STING Agonist by Engineered Silicasome for Potent Antitumor Immunotherapy

Advanced Science, EarlyView.
Engineered mesoporous silica nanoparticles (Silicasomes) enable systemic delivery of the STING agonist ADU‐S100, overcoming the instability and toxicity that limit cyclic dinucleotides to local administration. By enhancing tumor accumulation, activating systemic antitumor immunity, and remodeling the tumor immune microenvironment, these nanoparticles ...
Wenjing Zhou, Yuting Li, Xudong Sun, Honghong Yang, Xiayu Shi, Lijia Yao, Jinhong Jiang, Erli Wang, Haoyang Wang, Yi Wei, Xiangsheng Liu   +10 more
wiley   +1 more source

Relative and normalized iodine concentrations derived from photon counting computed tomography and their correlation with tumor grade and Ki67 in pancreatic neuroendocrine neoplasia: A pilot study. [PDF]

J Neuroendocrinol
Sähn MJ, Waltermann S, Ottemöller J, Diallo-Danebrock R, Niehoff JH, Bähr M, Gerdes B, Borggrefe J, Begum N, Surov A.   +9 more
europepmc   +1 more source

Assessment of HER2 and Ki67 in adenocarcinomas

, 2019
Biomarkers in tumor tissue can predict cancer behavior or can be targeted with targeted therapy. Two examples of such biomarkers are HER2 and Ki67. These biomarkers are assessed with stains on tissue of patients in clinical pathology.Timco Koopman is a resident in pathology and works at the pathology department of the UMCG. For his thesis he researched
openaire   +1 more source

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source

Genetic recording of pancreatic beta cell proliferation. [PDF]

Proc Natl Acad Sci U S A
Zhao H, Chen H, Kang Z, Huang X, Zhu J, Liu Z, Liu X, Han X, Lu J, Zhou B.   +9 more
europepmc   +1 more source