Results 91 to 100 of about 2,425,371 (368)

Antisense and the Kidney

Kidney and Blood Pressure Research, 1996
Antisense oligonucleotides are being used as gene-therapeutic agents. This short overview focuses on the in vivo kinetics and on potential in vivo applications for research purposes as well as therapeutic applications. The most promising experimental results have been obtained with oligonucleotides targeted against genes involved in cell proliferation,
Oberbauer, R, Murer, H, Schreiner, G F, Meyer, T W   +3 more
openaire   +2 more sources

IL-27: A Double-Edged Sword in Immune Regulation via JAK-STAT Orchestration

Journal of Immunology Research
Interleukin-27 (IL-27) is a multifunctional cytokine produced mainly by innate immune cells that regulates immune responses primarily through the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway. The role of IL-
Xiangqi Zhang, Chen Feng, Ye Xu, Yingqi Zeng, Qiulin Luo, Jiajie Qin, Tengfang Li, Longkai Peng, Hedong Zhang, Helong Dai   +9 more
doaj   +1 more source

Implementing a multisite shared haemodialysis care programme

BMJ Open Quality
Adults receiving centre-based haemodialysis (HD) have low levels of patient activation which are associated with poorer outcomes. Shared haemodialysis care (SHC) describes an intervention whereby individuals are supported to undertake elements of their ...
Udaya Prabhakar Udayaraj, David Green, Angela Pietrafesa, Marianne Reyes, Giada Donnini, Evelyn Gicana, Evelyn Nadurata, Juniya John, Jessica Ponting, Raji Srinivasan   +9 more
doaj   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Baseline total kidney volume and the rate of kidney growth are associated with chronic kidney disease progression in Autosomal Dominant Polycystic Kidney Disease

, 2018
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive enlargement of kidney cysts leading to chronic kidney disease (CKD) and end-stage renal disease (ESRD). Identification of an early biomarker that can predict progression
Flessner, Michael F., Vicente E. Torres, Yu, Alan S.L., Mrug, Michal, Grantham, Jared J., Rahbari-Oskoui, Frederic F., Michal Mrug, Harris, Peter C., Torres, Vicente E., Bennett, William M., Kyongtae T. Bae, Frederic F. Rahbari-Oskoui, Chapman, Arlene B., Landsittel, Douglas P., William M. Bennett, Shen, Chengli, Chengli Shen, Bae, Kyongtae T., Jared J. Grantham, Alan S.L. Yu, Arlene B. Chapman, Peter C. Harris, Douglas P. Landsittel, Michael F. Flessner   +23 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Decision letter for "Morphology and seasonality of the sexual segment of the kidney in genus Bothrops snakes"

, 2021

openalex   +1 more source

GEN1 as a risk factor for human congenital anomalies of the kidney and urinary tract

Human Genomics
Background Congenital anomalies of the kidney and urinary tract (CAKUT) are prevalent birth defects. Although pathogenic CAKUT genes are known, they are insufficient to reveal the causes for all patients.
Xuanjin Du, Chunyan Wang, Jialu Liu, Minghui Yu, Haixin Ju, Shanshan Xue, Yaxin Li, Jiaojiao Liu, Rufeng Dai, Jing Chen, Yihui Zhai, Jia Rao, Xiang Wang, Yubo Sun, Lei Sun, Xiaohui Wu, Hong Xu, Qian Shen   +17 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source