Results 91 to 100 of about 2,352,989 (309)

Current Perspective on the Location and Function of Gamma- Aminobutyric Acid (GABA) and its Metabolic Partners in the Kidney. [PDF]

, 2014
Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter located in the mammalian central nervous system, which binds to GABAA and GABAB receptors to mediate its neurological effects.
Peppiatt-Wildman, Claire M., Wildman, Scott S.P., Dunn, Kadeshia, Kelley, Stephen P., Wildman, Scott S. P.   +4 more
core   +1 more source

Kidney health for all: bridging the gap in kidney health education and literacy

, 2022
The high burden of kidney disease, global disparities in kidney care, and poor outcomes of kidney failure bring a concomitant growing burden to persons affected, their families, and carers, and the community at large.
Hsiao, Li-Li, Bonner, Ann, Tantisattamo, Ekamol, Laffin, Paul, Kalantar-Zadeh, Kamyar, Ulasi, Ifeoma, Lui, Siu-Fai, Kumaraswami, Latha A, Liakopoulos, Vassilios, Balducci, Alessandro, Langham, Robyn G, World Kidney Day Joint Steering Committee, Saadi, Gamal, Robyn G Langham, Gamal Saadi, Kamyar Kalantar-Zadeh, Siu-Fai Lui, Kamyar Kalantar–Zadeh, Ann Bonner, Alessandro Balducci, Li-Li Hsiao, Vassilios Liakopoulos, Ekamol Tantisattamo, Latha A Kumaraswami, null null, Latha Kumaraswami, Paul Laffin, Ifeoma Ulasi   +27 more
core   +1 more source

IL-27: A Double-Edged Sword in Immune Regulation via JAK-STAT Orchestration

Journal of Immunology Research
Interleukin-27 (IL-27) is a multifunctional cytokine produced mainly by innate immune cells that regulates immune responses primarily through the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway. The role of IL-
Xiangqi Zhang, Chen Feng, Ye Xu, Yingqi Zeng, Qiulin Luo, Jiajie Qin, Tengfang Li, Longkai Peng, Hedong Zhang, Helong Dai   +9 more
doaj   +1 more source

Implementing a multisite shared haemodialysis care programme

BMJ Open Quality
Adults receiving centre-based haemodialysis (HD) have low levels of patient activation which are associated with poorer outcomes. Shared haemodialysis care (SHC) describes an intervention whereby individuals are supported to undertake elements of their ...
Udaya Prabhakar Udayaraj, David Green, Angela Pietrafesa, Marianne Reyes, Giada Donnini, Evelyn Gicana, Evelyn Nadurata, Juniya John, Jessica Ponting, Raji Srinivasan   +9 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Metabolic syndrome, the leptin gene and kidney disease in non-diabetic black South Africans [PDF]

, 2008
Includes abstract.Includes bibliographical references (leaves 226-256).Obesity is a worldwide problem and is a factor in the pathogenesis of the metabolic syndrome and kidney disease through the development of obesity-related hypertension and ...
Okpechi, Ikechi Gareth
core   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

GEN1 as a risk factor for human congenital anomalies of the kidney and urinary tract

Human Genomics
Background Congenital anomalies of the kidney and urinary tract (CAKUT) are prevalent birth defects. Although pathogenic CAKUT genes are known, they are insufficient to reveal the causes for all patients.
Xuanjin Du, Chunyan Wang, Jialu Liu, Minghui Yu, Haixin Ju, Shanshan Xue, Yaxin Li, Jiaojiao Liu, Rufeng Dai, Jing Chen, Yihui Zhai, Jia Rao, Xiang Wang, Yubo Sun, Lei Sun, Xiaohui Wu, Hong Xu, Qian Shen   +17 more
doaj   +1 more source