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Over 65,000 Americans are diagnosed with kidney cancer each year and nearly 13,000 die of this disease. Kidney cancer is not a single disease, it is made up of a number of different types of cancer, each with a different histology, a different clinical course, responding differently to therapy and caused by a different gene. Study of the thirteen genes
W Marston, Linehan, W Kimryn, Rathmell
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Cigarette smoking and obesity may account for approximately 40% of cases in high-incidence countries. Continued research in kidney cancer is needed since nearly 50% of the patients die within five years after diagnosis.
Eunyoung, Cho, +5 more
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Epigenetics of Kidney Cancer And Bladder Cancer [PDF]
This article focuses on the epigenetic alterations of aberrant promoter hypermethylation of genes, and histone modifications or RNA interference in cancer cells. Current knowledge of the hypermethylation of allele(s) in classical tumor suppressor genes in inherited and sporadic cancer, candidate tumor suppressor and other cancer genes is summarized ...
Amanda M, Hoffman, Paul, Cairns
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From kidney injury to kidney cancer [PDF]
Epidemiologic studies document strong associations between acute or chronic kidney injury and kidney tumors. However, whether these associations are linked by causation, and in which direction, is unclear. Accumulating data from basic and clinical research now shed light on this issue and prompt us to propose a new pathophysiological concept with ...
Peired A. J. +4 more
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Examining the Relationship between Depression, Anxiety and Stress in Kidney Cancer Patients [PDF]
Cancer of the kidney is one of the 10 most common cancers found globally. Overall, it is the fourth most common cancer in men and the eighth most common cancer in women. Many kidney cancer patients experience psychologic problems and reactions.
Demirtaş, Türev +3 more
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We quantified the burden of kidney cancer in the United States by identifying trends in the use of health care resources and estimating the economic impact of the disease.The analytical methods used to generate these results were described previously.The incidence of all stages of kidney cancer is increasing in America, particularly T1 disease.
Eric M, Wallen +3 more
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In this Focus (Cancer Cell 6, pp. 223–228), the legends for Figure 1, Figure 2 were reversed. They are reprinted below with the proper captions. Additionally, Figure 1Figure 1 should be cited at the end of the second-to-last sentence of the section “Studies of dominantly inherited, epithelial forms of renal carcinoma,” the citation at the end of the ...
Linehan, W.Marston, Zbar, Berton
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Epidemiology of Kidney Cancer [PDF]
Some tumors are known to have a definite cause-effect etiology, but renal cell carcinoma (RCC) is not one of them precisely. With regard to RCC we can only try to identify some clinical and occupational factors as well as substances related to tumorigenesis.
D. Pascual, A. Borque
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Second Primary Cancers After Kidney Cancers, and Kidney Cancers as Second Primary Cancers
Second primary cancers (SPCs) are increasing due to improving survival in first primary cancers. Previous studies on SPCs in renal cell carcinoma (RCC) have focused on treatment and other risk factors, but data of RCC as an SPC are scarce.In this study, we want to elucidate the risk for any SPC after RCC, and in reverse order, for RCC as an SPC after ...
Zheng, Guoqiao +6 more
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The human gonadotropin-releasing hormone receptor GnRH1R is a GPCR with an important role in the human reproductive system and of interest as a drug target.
Wei Yan +11 more
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