Results 41 to 50 of about 4,369,422 (307)

Abnormal liver tests are not sufficient for diagnosis of hepatic graft‐versus‐host disease in critically ill patients

Hepatology Communications, 2022
Hepatic graft‐versus‐host disease (HGVHD) contributes significantly to morbidity and mortality after hematopoietic stem cell transplantation (HSCT). Clinical findings and liver biomarkers are neither sensitive nor specific.
Alexander H. Yang, Mai Ai Thanda Han, Niharika Samala, Bisharah S. Rizvi, Rachel Marchalik, Ohad Etzion, Elizabeth C. Wright, Ruchi Patel, Vinshi Khan, Devika Kapuria, Vikramaditya Samala Venkat, David E. Kleiner, Christopher Koh, Jennifer A. Kanakry, Christopher G. Kanakry, Steven Pavletic, Kirsten M. Williams, Theo Heller   +17 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Neuropeptide G Protein-Coupled Receptors as Oncotargets

Frontiers in Endocrinology, 2018
Neuropeptide G protein-coupled receptors (GPCRs) are overexpressed on numerous cancer cells. In a number of tumors, such as small cell lung cancer (SCLC), bombesin (BB) like peptides and neurotensin (NTS) function as autocrine growth factors whereby they
Terry W. Moody, Irene Ramos-Alvarez, Robert T. Jensen   +2 more
doaj   +1 more source

Kidney Function, Proteinuria, and Cancer Incidence: The Korean Heart Study

, 2017
BACKGROUND: Reported associations of estimated glomerular filtration rate (eGFR) with cancer risk are inconsistent, and data for the proteinuria-cancer relationship are sparse. We sought to quantify the associations of cancer incidence with eGFR and with
지선하, 정금지
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The Efficacy and Safety of Tyrosine Kinase Inhibitors for Von Hippel–Lindau Disease: A Retrospective Study of 32 Patients

Frontiers in Oncology, 2019
Background: Von Hippel-Lindau (VHL) disease is an autosomal-dominant hereditary cancer syndrome. Currently, studies on tyrosine kinase inhibitor (TKI) therapy for VHL disease are scarce. In this study, we retrospectively evaluated the efficacy and safety
Kaifang Ma, Kaifang Ma, Kaifang Ma, Kaifang Ma, Baoan Hong, Baoan Hong, Jingcheng Zhou, Jingcheng Zhou, Jingcheng Zhou, Jingcheng Zhou, Yanqing Gong, Yanqing Gong, Yanqing Gong, Yanqing Gong, Jiangyi Wang, Shengjie Liu, Xiang Peng, Bowen Zhou, Bowen Zhou, Bowen Zhou, Bowen Zhou, Jiufeng Zhang, Jiufeng Zhang, Jiufeng Zhang, Jiufeng Zhang, Haibiao Xie, Haibiao Xie, Haibiao Xie, Haibiao Xie, Kenan Zhang, Kenan Zhang, Kenan Zhang, Kenan Zhang, Lei Li, Lei Li, Lei Li, Lei Li, Desheng Cai, Desheng Cai, Desheng Cai, Desheng Cai, Zixin Wang, Zixin Wang, Zixin Wang, Zixin Wang, Lin Cai, Lin Cai, Lin Cai, Lin Cai, Kan Gong, Kan Gong, Kan Gong, Kan Gong   +52 more
doaj   +1 more source

Childhood, adolescent and young adult cancer: cancer trends report

, 2023
This is the third Cancer Trends Report the National Cancer Registry Ireland (NCRI) has published on childhood cancers and the first to include cancers in adolescents and young adults (AYA) (up to 24 years of age).
National Cancer Registry Ireland (NCRI)
core  

Kidney

, 2022
The folder contains: Metabolites-based_tissue and Metabolites_, Enzymes-, Reactions-based_PDGSMMs networks of kidney cancer in graphml format; sample_sheet.tsv tabular file containing GDC samples metadata, namely clinical information of samples ...
Ichcha Manipur (9294179), Lucia Maddalena (9294182), Ilaria Granata (1906462), Mario Guarracino (3431300), Giordano Maurizio (11730081)   +4 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source