Results 51 to 60 of about 4,369,422 (307)

Metabolomic landscape of renal cell carcinoma in von Hippel-Lindau syndrome in a Chinese cohort

iScience
Summary: Von Hippel-Lindau (VHL) syndrome is a rare autosomal dominant disorder, where renal cell carcinoma (RCC) serves as a significant cause of mortality. We collected peripheral blood from 61 VHL-RCC patients and 31 healthy individuals, along with 19
Zedan Zhang, Yi Wang, Wuping Yang, Tao Liu, Chuandong Wang, Cong Huang, Yawei Xu, Xiaolin Chen, Jingcheng Zhou, Yizhou Wang, Xiaohua Zhou, Yanqing Gong, Kan Gong   +12 more
doaj   +1 more source

Selective In Vitro Propagation of Nephron Progenitors Derived from Embryos and Pluripotent Stem Cells

Cell Reports, 2016
Nephron progenitors in the embryonic kidney propagate while generating differentiated nephrons. However, in mice, the progenitors terminally differentiate shortly after birth.
Shunsuke Tanigawa, Atsuhiro Taguchi, Nirmala Sharma, Alan O. Perantoni, Ryuichi Nishinakamura   +4 more
doaj   +1 more source

Cancer trends: Breast, cervical and colorectal cancer 1994-2019: National trends for cancers with population-based screening programmes in Ireland

, 2022
The overall burden of cancer in Ireland is increasing, primarily due to population growth and ageing, with the annual number of cases of breast cancer, cervical cancer and colorectal cancer estimated to increase by 50%, 56% and 113% respectively by 2045 ...
National Cancer Registry Ireland (NCRI)
core  

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Targeting metabolic vulnerability by combining NAMPT inhibitors and disulfiram for treatment of recurrent ovarian cancer

Cell Death and Disease
Ovarian cancer (OV) has the highest mortality rate among gynecological cancers. As OV progresses, tumor cells spread outside the ovaries to the peritoneal and abdominal cavities, forming cell clusters that float in the ascitic fluid caused by peritonitis
Kei Kudo, Yoshimi Endo Greer, Daniel R. Crooks, Ye Yang, Jeffrey R. Brender, Teruhiko Yoshida, Brittney S. Harrington, Rahul Kamdar, Soumya Korrapati, Yusuke Shibuya, Leah Henegar, Jeffrey Kopp, Takeo Fujii, Stanley Lipkowitz, Christina M. Annunziata   +14 more
doaj   +1 more source

Co-creating with patients an impact framework across the medicine’s life cycle: a qualitative study exploring patients’ experiences of involvement in and perceptions of impact measures

Research Involvement and Engagement, 2022
Plain English summary Developing medicines involves multiple stages, all essential for pharmaceutical companies. However, this approach is becoming increasingly costly and patients are rarely involved in defining treatment outcomes.
Oleks Gorbenko, Pascale Cavillon, Rachel H. Giles, Teodora Kolarova, Muriël Marks, Antonella Cardone, Sandeep Bagga, Claire Nolan   +7 more
doaj   +1 more source

Treating kidney cancer – a review [PDF]

, 2020
Introduction. Kidney cancer in the structure of registered cases was in 6th place in men and 8th in women. Aim. Understanding the molecular biology of renal cell carcinoma has made it possible to produce new diagnostic methods. Material and methods. This
Bartusik-Aebisher, Dorota, Ewa Kaznowska, Kaznowska, Ewa, Piotr Przyczyna, Przyczyna, Piotr, Dorota Bartusik-Aebisher, Aebisher, David, David Aebisher   +7 more
core   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Ontological analyses reveal clinically-significant clear cell renal cell carcinoma subtypes with convergent evolutionary trajectories into an aggressive typeResearch in context

EBioMedicine, 2020
Background: Clear cell renal cell carcinoma (ccRCC) is a particularly challenging tumor type because of its extensive phenotypic variability as well as intra-tumoral heterogeneity (ITH).
Qi Cai, Alana Christie, Satwik Rajaram, Qinbo Zhou, Ellen Araj, Suneetha Chintalapati, Jeffrey Cadeddu, Vitaly Margulis, Ivan Pedrosa, Dinesh Rakheja, Renee M. McKay, James Brugarolas, Payal Kapur   +12 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source