Results 61 to 70 of about 4,369,422 (307)

Nephron Sparing Treatment (NEST) for small renal masses: understanding patients’ and clinicians’ experiences of a cohort-embedded randomised control trial

Pilot and Feasibility Studies
Background To understand the perspectives and experiences of patients and healthcare professionals regarding the trial design, recruitment and randomisation process to a novel cohort-embedded RCT design for Nephron Sparing Treatment (NEST) for small ...
Veronica Ranieri, Hannah Warren, Joana B. Neves, Joseph Santiapillai, Nicola Rode, David Cullen, Graham Munneke, Miles Walkden, Prasad Patki, Ravi Barod, Faiz Mumtaz, Michael Aitchison, Elena Pizzo, Norman R. Williams, William H. Wildgoose, Kurinchi Gurusamy, Mark Emberton, Axel Bex, Maxine G. B. Tran   +18 more
doaj   +1 more source

Efficacy and safety of Androgen Deprivation Therapy (ADT) combined with modified docetaxel chemotherapy versus ADT combined with standard docetaxel chemotherapy in patients with metastatic castration-resistant prostate cancer: study protocol for a multicentre prospective randomized controlled trial

BMC Cancer, 2022
Background Androgen deprivation therapy (ADT) combined with docetaxel chemotherapy is the standard treatment for metastatic castration-resistant prostate cancer (mCRPC) patients.
Xiangwei Yang, Hong Chen, Duanya Xu, Xianju Chen, Yamei Li, Jun Tian, Dongwen Wang, Jun Pang   +7 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Proceedings of IKCS North America 2025 - Abstracts

We are pleased to present the abstracts accepted for the 2025 IKCS North America meeting! The research detailed here will be presented on stage and exhibited during our meeting, representing the best of what our scientific community has to offer.
INTERNATIONAL KIDNEY CANCER SYMPOSIUM: NORTH AMERICA
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Prospect of acromegaly therapy: molecular mechanism of clinical drugs octreotide and paltusotine

Nature Communications, 2023
Somatostatin receptor 2 (SSTR2) represents a therapeutic target of neuroendocrine tumors. Here, authors report two structures of SSTR2 bound to peptide octreotide and small molecule paltusotine, revealing the basis subtype selectivity and signal bias ...
Jie Zhao, Hong Fu, Jingjing Yu, Weiqi Hong, Xiaowen Tian, Jieyu Qi, Suyue Sun, Chang Zhao, Chao Wu, Zheng Xu, Lin Cheng, Renjie Chai, Wei Yan, Xiawei Wei, Zhenhua Shao   +14 more
doaj   +1 more source

Cancer risks in people on dialysis and kidney transplant recipients: a Catalan cohort study, 2003-21 [PDF]

Background: People with kidney failure have a higher risk of cancer compared with age- and sex-matched individuals in the general population, yet data from southern Europe are limited. This study explores cancer incidence in the kidney failure population
Coloma, Ana, Codina, Sergi, Lloberas, Nuria, Oliveras, Laia, Manonelles, Anna, Lloberas Blanch, Núria, Ribes Puig, Josepa, Oliveras Pagès, Laia, Borràs Andrés, Josep Maria, Montero Pérez, Núria, Martinez-Carbonell, Elisenda, Pareja, Laura, Tort i Donada, Joan, 1958-, Favà, Àlex, Borras, Josep M, Couceiro Monteagudo, Carlos, Manonelles Montero, Anna, Couceiro, Carlos, Cruzado, Josep Ma., Melilli, Edoardo, Montero, Nuria, Gálvez, Jordi, Tort, Jaume, Comas, Jordi, Mosteiro Molina, Sonia, CRUZADO, JOSEP M, Mosteiro, Sonia   +26 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

National Aboriginal and Torres Strait Islander cancer framework 2015 [PDF]

, 2015
Overview The National Aboriginal and Torres Strait Islander Cancer Framework (the Framework) provides high-level guidance and direction for the many individuals, communities, organisations and governments whose combined efforts are required to address ...
Cancer Australia
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source