Results 71 to 80 of about 1,036,066 (335)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Journal of Lipid Research, 2009 Pregnane X receptor (PXR) is an important nuclear receptor xenosensor that regulates the expression of metabolic enzymes and transporters involved in the metabolism of xenobiotics and endobiotics.
Joo-Youn Cho +7 more
doaj +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
AM-37 and ST-36 Are Small Molecule Bombesin Receptor Antagonists
Frontiers in Endocrinology, 2017 While peptide antagonists for the gastrin-releasing peptide receptor (BB2R), neuromedin B receptor (BB1R), and bombesin (BB) receptor subtype-3 (BRS-3) exist, there is a need to develop non-peptide small molecule inhibitors for all three BBR.
Terry W. Moody +6 more
doaj +1 more source
Pan-urologic cancer genomic subtypes that transcend tissue of origin [PDF]
, 2017 Urologic cancers include cancers of the bladder, kidney, prostate, and testes, with common molecular features spanning different types. Here, we show that 1954 urologic cancers can be classified into nine major genomic subtypes, on the basis of ...
Bossé, Dominick +9 more
core +2 more sources
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Journal of Experimental & Clinical Cancer Research, 2022 Background Distant metastasis is the major cause of clear cell renal cell carcinoma (ccRCC)-associated mortality. However, molecular mechanisms involved in ccRCC metastasis remain to be fully understood.
Yanliang Wang +15 more
doaj +1 more source
To what extent acute exposure to volcanic gases affects cells of the respiratory epithelium, peripheral oxygen saturation and lung funcion? [PDF]
, 2018 Dissertação de Mestrado, Ciências Biomédicas, 31 de julho de 2018, Universidade dos Açores.O vulcão das Furnas encontra-se localizado na parte oriental da ilha de São Miguel (Açores, Portugal), onde a actividade vulcânica é marcada por várias ...
Tavares, Wilson Rodrigues
core
, 2017 In September, 10 advanced practice nurses from the Department of Surgery gathered for a lunchtime kick-off meeting to form a Nurse Practitioners (NPs) & Physician Assistants (PAs) Professionalism and Scholarship Working Group.
core +2 more sources