Results 71 to 80 of about 921,567 (386)

Bombesin Receptor Family Activation and CNS/Neural Tumors: Review of Evidence Supporting Possible Role for Novel Targeted Therapy

Frontiers in Endocrinology, 2021
G-protein-coupled receptors (GPCRs) are increasingly being considered as possible therapeutic targets in cancers. Activation of GPCR on tumors can have prominent growth effects, and GPCRs are frequently over-/ectopically expressed on tumors and thus can ...
Terry W. Moody, Lingaku Lee, Lingaku Lee, Irene Ramos-Alvarez, Tatiana Iordanskaia, Samuel A. Mantey, Robert T. Jensen   +6 more
doaj   +1 more source

Urinary cholesterol in cancer screening [PDF]

, 1982
Cholesterol determinations in morning urine samples were taken in 235 selected patients with a positive test for microscopic hematuria. Values ranged from 0.2 to 76.0 mg (median 5.5) in 23 patients with urologic malignancies and from 0.1 to 33.4 mg ...
Acevedo, Belis, Bloch, Bruger, Burchell, Chu, Comings, Frick, Jüngst, Jüngst, Jüngst, Jüngst, Klahr, Neumann, Spiteller-Friedmann, Trappe, Zimmer   +16 more
core   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Targeting metabolic vulnerability by combining NAMPT inhibitors and disulfiram for treatment of recurrent ovarian cancer

Cell Death and Disease
Ovarian cancer (OV) has the highest mortality rate among gynecological cancers. As OV progresses, tumor cells spread outside the ovaries to the peritoneal and abdominal cavities, forming cell clusters that float in the ascitic fluid caused by peritonitis
Kei Kudo, Yoshimi Endo Greer, Daniel R. Crooks, Ye Yang, Jeffrey R. Brender, Teruhiko Yoshida, Brittney S. Harrington, Rahul Kamdar, Soumya Korrapati, Yusuke Shibuya, Leah Henegar, Jeffrey Kopp, Takeo Fujii, Stanley Lipkowitz, Christina M. Annunziata   +14 more
doaj   +1 more source

LncRNA MILIP links YBX1 to translational activation of Snai1 and promotes metastasis in clear cell renal cell carcinoma

Journal of Experimental & Clinical Cancer Research, 2022
Background Distant metastasis is the major cause of clear cell renal cell carcinoma (ccRCC)-associated mortality. However, molecular mechanisms involved in ccRCC metastasis remain to be fully understood.
Yanliang Wang, Yu Chen Feng, Yujin Gan, Liu Teng, Li Wang, Ting La, Peilin Wang, Yue Gu, Lei Yan, Na Li, Lina Zhang, Limeng Wang, Rick F. Thorne, Xu Dong Zhang, Huixia Cao, Feng-Min Shao   +15 more
doaj   +1 more source

ORGAN SPECIFIC VASCULAR RESPONSE TO FIBROSIS AFFECTS BREAST CANCER METASTATIC ORGANOTROPISM [PDF]

, 2016
The solid tumor microenvironment, pre-metastatic niche, and fibrotic environment are known to have significant biochemical and biomechanical similarities to the fibrotic environment. All have significantly increased levels of factors such as TGFβ, HIF1α,
Fletcher, Eliot S, Fletcher, Eliot S
core   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

AM-37 and ST-36 Are Small Molecule Bombesin Receptor Antagonists

Frontiers in Endocrinology, 2017
While peptide antagonists for the gastrin-releasing peptide receptor (BB2R), neuromedin B receptor (BB1R), and bombesin (BB) receptor subtype-3 (BRS-3) exist, there is a need to develop non-peptide small molecule inhibitors for all three BBR.
Terry W. Moody, Nicole Tashakkori, Samuel A. Mantey, Paola Moreno, Irene Ramos-Alvarez, Marcello Leopoldo, Robert T. Jensen   +6 more
doaj   +1 more source

Studies on the clinical significance of nonesterified and total cholesterol in urine [PDF]

, 1981
Gas-liquid chromatographic determinations of nonesterified and total urinary cholesterol were performed in 137 normals, 264 patients with various internal diseases without evidence of neoplasias or diseases of the kidney or urinary tract, 497 patients ...
A. Pickel, A. Stadler, BA Vela, D Jüngst, D Jüngst, D. Jüngst, DE Comings, E Bloch, F. J. Marsx, H Sobotka, H Sobotka, H. J. Karl, HF Acevedo, HF Acevedo, HF Acevedo, HF Acevedo, HF Acevedo, HF Acevedo, J Bing, J Frick, J. Wallner, JA Belis, JC Sutherland, JG Zimmer, JW Eagen, M Bruger, M Bruger, M Spiteller-Friedmann, MM Burchell, MM Burchell, P Kerkhoven, S Klahr, SG Mendoza de, TM Chu, W Trappe, W. Eiermann   +35 more
core   +2 more sources

Cancer of a Movable Kidney [PDF]

The American Journal of the Medical Sciences, 1898
n ...
openaire   +2 more sources