Results 81 to 90 of about 921,567 (386)

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Genistein increases epidermal growth factor receptor signaling and promotes tumor progression in advanced human prostate cancer. [PDF]

, 2011
Genistein is an isoflavone found in soy, and its chemo-preventive and -therapeutic effects have been well established from in vitro studies. Recently, however, its therapeutic actions in vivo have been questioned due to contradictory reports from animal ...
Adomat, Hans, Cunha, Gerald R, Kurita, Takeshi, Nakamura, Hisae, Wang, Yuwei, Wang, Yuzhuo   +5 more
core   +4 more sources

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

Technical report: Kidney tumor segmentation using a 2D U-Net followed by a statistical post-processing filter [PDF]

arXiv, 2020
Each year, there are about 400'000 new cases of kidney cancer worldwide causing around 175'000 deaths. For clinical decision making it is important to understand the morphometry of the tumor, which involves the time-consuming task of delineating tumor and kidney in 3D CT images.
arxiv  

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Upper Tract Urothelial Tumor with Renal Vein and Inferior Vena Cava Thrombus Case Report [PDF]

, 2017
Introduction: Urothelial tumors of upper tract are uncommon in clinical practice compared to other renal malignancy. Presentation of Case: A 71-year-old man with multiple co-morbidities who presented with generalized non-specific symptoms was worked up ...
Raed A, Alturki A
core   +1 more source

Recent developments in kidney cancer [PDF]

Canadian Urological Association Journal, 2011
Renal cell carcinoma (RCC) diagnosis and management haveundergone significant shifts in the recent past. The increasing rateof diagnosis of small renal masses, often in patients at high risk ofmorbidity with operative treatment, has led to studies, trials anddiscoveries in renal mass biopsy, active surveillance and minimallyinvasive thermal ablation ...
Michael A.S. Jewett, Michael Leveridge
openaire   +4 more sources

Integrative Pan-Cancer Analysis of RNMT: a Potential Prognostic and Immunological Biomarker [PDF]

arXiv, 2022
Background: RNA guanine-7 methyltransferase (RNMT) is one of the main regulators of N7-methylguanosine, and the deregulation of RNMT correlated with tumor development and immune metabolism. However, the specific function of RNMT in pan-cancer remains unclear.
arxiv  

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

The Role of Interleukin-10 in Women with Metastatic Invasive Ductal Carcinoma

مجلة كلية الطب, 2011
Background: Breast cancer is the malignant tumor that forms from the uncontrolled growth of abnormal breast cells. It usually affects tissues involved in milk production (Ductal and lobular tissues).
Amina N. Althwani, Mohammed A. Najm
doaj   +1 more source