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Immunological Reviews, 2022 SummaryDysregulation and accelerated activation of the alternative pathway (AP) of complement is known to cause or accentuate several pathologic conditions in which kidney injury leads to the appearance of hematuria and proteinuria and ultimately to the development of chronic renal failure.
Erica Daina +2 more
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Polycystic kidney disease [PDF]
Nature Reviews Disease Primers, 2018 Cystic kidneys are common causes of end-stage renal disease, both in children and in adults. Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD) are cilia-related disorders and the two main forms of monogenic cystic kidney diseases.
Bergmann, C. +5 more
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International Journal of Endocrinology, 2022 Purpose. Chronic malnutrition and cachexia are common in chronic kidney disease (CKD), and importance should be given to these complications because they affect the patient’s quality of life and prognosis.
Lilin Liu +6 more
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Prescription characteristics of phosphate binders in a high pill burden for hemodialysis patients
Renal Replacement Therapy, 2021 Background Dialysis patients have to take many oral drugs, causing a high pill burden. Phosphate binders (PBs) account for a large proportion of daily pill burden; however, the relationship between patient background and prescription status of PBs is not
Nobuo Nagano +8 more
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Kidney: polycystic kidney disease [PDF]
WIREs Developmental Biology, 2014 Polycystic kidney disease (PKD) is a life‐threatening genetic disorder characterized by the presence of fluid‐filled cysts primarily in the kidneys. PKD can be inherited as autosomal recessive (ARPKD) or autosomal dominant (ADPKD) traits. Mutations in either the PKD1 or PKD2 genes, which encode polycystin 1 and polycystin 2, are the underlying cause of
Binu M, Paul, Gregory B, Vanden Heuvel
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BMC Nephrology, 2023 Background Crescentic immunoglobulin A (IgA) nephropathy, defined as > 50% of the glomeruli with crescents, often has a poor renal prognosis. Because of the high prevalence of pre-eclampsia in the second trimester of pregnancy, we often fail to ...
Hisato Shima +8 more
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Primary Care: Clinics in Office Practice, 2020 Chronic kidney disease is encountered by the primary care physician, in no small part owing to the high rates of hypertension and diabetes, the 2 most common etiologies of chronic kidney disease in the United States. As a primary care physician, it is important to understand the epidemiology, pathophysiology, and evaluation methods of chronic kidney ...
Cornelia, Charles, Allison H, Ferris
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The Lancet, 2017 The definition and classification of chronic kidney disease (CKD) have evolved over time, but current international guidelines define this condition as decreased kidney function shown by glomerular filtration rate (GFR) of less than 60 mL/min per 1·73 m2, or markers of kidney damage, or both, of at least 3 months duration, regardless of the underlying ...
Angela C, Webster +3 more
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BMC Nephrology, 2021 Background Minimal change disease is a common cause of nephrotic syndrome in adults. Higher relapse rate put patients at risk of steroids toxicity due to long-term exposure.
Diankun Liu +8 more
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Renal Replacement Therapy, 2023 Background Stenotrophomonas maltophilia (S. maltophilia) is being increasingly recognized as an important cause of nosocomial infections, particularly in immunocompromised patients, such as patients undergoing dialysis. S.
Hisato Shima +8 more
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