Results 111 to 120 of about 5,638,461 (310)
Nihon Naika Gakkai Zasshi, 1996 多発性嚢胞腎には,常染色体優性多発性嚢胞腎(ADPKD)と常染色体劣性多発性嚢胞腎(ARPKD)がある. ADPKDは,多発性の腎嚢胞が出現し,腎機能が進行性に低下することと,頭蓋内出血が生命を脅かす主要な病態である. ADPKDの遺伝子異常には少なくとも二つの異なった部位が知られている. PKD1は腎機能の予後,嚢胞の程度がPKD2より厳しい.第16番染色体短腕にPKD1が同定され, PKD1蛋白は, 11回細胞膜を貫いて存在する糖蛋白で,細胞細胞間,あるいは細胞マトリックス間の結合に関与していることが推測されている.第4番染色体長腕上にPKD2の遺伝子が同定され,その蛋白は刺激伝達系に関与していることが推測されている.
openaire +2 more sources
Comparison Of Oral Iron and Iv Iron Sucrose for Treatment of Anemia in Postpartum Indian Women
National Journal of Community Medicine, 2012 Objectives: To determine the efficacy of intravenous iron sucrose and oral iron in anaemic postpartum women, presenting at Institute of Kidney Disease and Research Centre. Method: Descriptive case series.
Aggarwal Rohina S +5 more
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
, 2022 [This corrects the article DOI: 10.1016/j.ekir.2018.01.002.]
Chronic Kidney Disease Prognosis Consortium
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Monogenic kidney diseases in adults with chronic kidney disease
Deutsches Ärzteblatt internationalAccording to current evidence, every 10th to 11th adult with chronic kidney disease (CKD) has a monogenic disease of the kidney.This review is based on reported studies in which molecular genetic diagnostic techniques were used to investigate monogenic kidney diseases in adults with CKD.
Eble, Julian +2 more
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Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Renal Replacement TherapyBackground Dextromethorphan (DXM) misuse, particularly among young individuals, has risen owing to its euphoric and hallucinogenic effects. High-dose DXM ingestion can trigger serotonin syndrome, a condition characterized by psychiatric, neuromuscular ...
Kazuhiro Okamoto +8 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source