Results 211 to 220 of about 587,070 (347)

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Culture and Adaptation of Pseudomonas aeruginosa During Early Infection in Children With Cystic Fibrosis. [PDF]

J Infect Dis
Mitra SD, Soneji M, Axline CMR, Hayden HS, Radey MC, Forsberg CM, Ozer EA, Wolter DJ, Pope CE, Burns J, Hoffman LR, Mayer-Hamblett N, Singh P, Hauser AR.   +13 more
europepmc   +1 more source

Mitochondrial dysfunction in inherited renal disease and acute kidney injury

Nature Reviews Nephrology, 2016
F. Emma, G. Montini, S. Parikh, L. Salviati   +3 more
semanticscholar   +1 more source

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, Volume 13, Issue 7, 3 February 2026.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Bilateral Perinephric Pseudocysts in an Owl Monkey. [PDF]

J Med Primatol
Gozalo AS, Lambert LE, Elkins WR.
europepmc   +1 more source

Characteristics of renal cystic and solid lesions based on contrast-enhanced computed tomography of potential kidney donors.

American Journal of Kidney Diseases, 2012
A. Rule, Kewalee Sasiwimonphan, J. Lieske, M. Keddis, V. Torres, T. Vrtiska   +5 more
semanticscholar   +1 more source

Economic Burden of Sickle Cell Disease: A Retrospective Study of Pediatric and Adult Individuals With Medicaid Coverage From 2016 to 2020

American Journal of Hematology, Volume 101, Issue 2, Page 269-280, February 2026.
ABSTRACT There is limited information regarding the contemporary real‐world clinical and financial burden of Medicaid enrollees with sickle cell disease (SCD) in the United States. Using the IBM MarketScan Medicaid database (7/2016–12/2020), individuals with ≥ 3 SCD diagnoses were matched 1:1 on age, gender, and race to individuals without SCD ...
Giovanna Tedesco Barcelos, Telma Peixoto, Jose Alvir, Jay Lin, Christine L. Baker   +4 more
wiley   +1 more source

Case Report: An atypical case of ARPKD highlights the utility and challenges of implementing genetic testing in cystic kidney disease. [PDF]

Front Pediatr
Marquez J, Hawkins LM, Beck AE, Dipple KM, Glass IA, Keefe AC, Nguyen ED.   +6 more
europepmc   +1 more source

G-protein signaling modulator 1 deficiency accelerates cystic disease in an orthologous mouse model of autosomal dominant polycystic kidney disease

Proceedings of the National Academy of Sciences of the United States of America, 2012
Michelle P. Kwon, T. Pavlov, K. Nozu, Shauna Rasmussen, D. Ilatovskaya, A. Lerch-Gaggl, Lauren M. North, Hyunho Kim, F. Qian, W. Sweeney, E. Avner, J. Blumer, A. Staruschenko, F. Park   +13 more
semanticscholar   +1 more source

Chemical Profiling, In Silico and In Vitro Studies to Identify Potential CDK2 and mTOR Inhibitor From Selaginella inaequalifolia (Hook. & Grev.) Spring Ethanolic Extracts

Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.
ABSTRACT The current study is aimed to reveal the phytoprofile of Selaginella inaequalifolia (Hook. & Grev.) Spring using GC–MS and predict the drug properties, toxicity, biological properties of S. inaequalifolia ethanolic extracts (SiEE) using in silico methods and in vitro toxicity assays, namely, MTT and BSLB assay.
Johnson Marimuthu Alias Antonysamy, Sivaraman Arumugam, Robin Charles Antony Arulraj, Anne Wincy Jacob Thomas, Henrique D. M. Coutinho   +4 more
wiley   +1 more source