Results 141 to 150 of about 10,805,577 (430)
In Silico Approaches and the Role of Ontologies in Aging Research [PDF]
, 2013 The 2013 Rostock Symposium on Systems Biology and Bioinformatics in Aging Research was again dedicated to dissecting the aging process using in silico means.
Busch, Hauke +14 more
core
, 2019 Ultrasound and conventional radiographs still remain the first-line radiological tools for most of the kidney disorders. Ultrasonographic image quality has been astonishingly improved in recent years with the development of technology and software ...
Ayaz, Ercan
core +1 more source
Arterial hypertension and the kidney: The fatal duo of chronic noncommunicable diseases [PDF]
, 2020 Chronic noncommunicable diseases are the leading cause of death in the world. Among them, cardiovascular diseases occupy first place in mortality and the main risk factor is hypertension, which is usually asymptomatic until the harmful effects manifest ...
Asdrúbal, Aguilera-Méndez +3 more
core +2 more sources
Possible role of human ribonuclease dicer in the regulation of R loops
FEBS Open Bio, EarlyView.R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik +2 more
wiley +1 more source
The clinical relevance of plasma CD147/basigin in biopsy-proven kidney diseases [PDF]
, 2018 Background: Precise understanding of kidney disease activity is needed to design therapeutic strategies. CD147/basigin is involved in the pathogenesis of acute kidney injury and renal fibrosis through inflammatory cell infiltration.
86908 +29 more
core +1 more source
NefrologíaReceptor interacting protein kinase 3 (RIPK3) is an intracellular kinase at the crossroads of cell death and inflammation. RIPK3 contains a RIP homotypic interaction motif (RHIM) domain which allows interactions with other RHIM-containing proteins and a kinase domain that allows phosphorylation of target proteins.
Guerrero Mauvecin, Juan +4 more
openaire +5 more sources
Genetics of kidney disease [PDF]
Kidney International, 2003 Multiple lines of evidence suggest that susceptibility to develop end-stage renal disease (ESRD) has a significant genetic component. These studies include familial aggregation studies, comparisons of incidence rates between different racial or ethnic populations, and segregation analysis. Multiple approaches have been employed in an effort to identify
openaire +3 more sources
FEBS Open Bio, EarlyView.Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei +7 more
wiley +1 more source
TRPC Channels in Proteinuric Kidney Diseases
Cells, 2019 Over a decade ago, mutations in the gene encoding TRPC6 (transient receptor potential cation channel, subfamily C, member 6) were linked to development of familial forms of nephrosis. Since this discovery, TRPC6 has been implicated in the pathophysiology
G. Hall, Liming Wang, R. Spurney
semanticscholar +1 more source
Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis [PDF]
, 2017 IgA nephropathy (IgAN) is the most prevalent among primary glomerular diseases worldwide. Although our understanding of IgAN has advanced significantly, its underlying biology and potential drug targets are still unexplored.
Cisek, Katryna +11 more
core +2 more sources