Results 131 to 140 of about 14,135,306 (260)

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Autophagy in Chronic Kidney Diseases

Cells, 2019
Autophagy is a cellular recycling process involving self-degradation and reconstruction of damaged organelles and proteins. Current evidence suggests that autophagy is critical in kidney physiology and homeostasis.
Tien-An Lin, V. Wu, Chao-Yung Wang
semanticscholar   +1 more source

World Kidney Day 2012: the global role of kidney transplantation.

, 2012
There remain major challenges to providing optimal treatment for ESRD worldwide and a need, particularly in low-income economies, to mandate more focus on community screening and implementation of simple measures to minimize progression of chronic kidney
Harden, P.N., García, G.G., Chapman, J.R.   +2 more
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Exertional heat stroke-related acute kidney injury: novel animal and cellular models

Renal Failure
Exertional heat stroke (EHS) is a life-threatening condition frequently complicated by acute kidney injury (AKI), yet standardized experimental models remain limited. This study aimed to establish reproducible in vivo and in vitro models specifically for
Jiaona Liu, Jing Hao, Pengfei Kang, Yingjie Zhang, Wanjun Shen, Pu Chen, Jingjing Chen, Xuefeng Sun, Xiangmei Chen   +8 more
doaj   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Management and treatment of glomerular diseases (part 1): conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

, 2019
The Kidney Disease: Improving Global Outcomes (KDIGO) initiative organized a Controversies Conference on glomerular diseases in November 2017. The conference focused on the 2012 KDIGO guideline with the aim of identifying new insights into nomenclature ...
Noiri, E, Lv, J, Nester, CM, Ronco, P, Malvar, A, Liew, A, Caster, DJ, Jha, V, Adler, SG, Katafuchi, R, Mok, CC, Wenderfer, SE, Wheeler, DC, Jennette, JC, O'Shaughnessy, MM, Barbour, SJ, Rovin, BH, Choo, JCJ, Roccatello, D, Coppo, R, Lafayette, RA, Hogan, JJ, Pendergraft, WF, Bagga, A, Iseki, K, Hodson, EM, Cheung, M, Radhakrishnan, J, Cattran, DC, Kaname, S, Tang, SCW, Walters, GD, Floege, J, Chang, A, Chan, DTM, Fervenza, FC, Smoyer, WE, Mejía-Vilet, JM, Parikh, SM, Li, PKT, Wetzels, JFM, Cook, HT, Pillebout, E, Vivarelli, M, Glassock, RJ, Moeller, MJ, Özen, S, Alpers, CE, Gibson, KL, Thurman, JM, Peh, CA, Tesař, V, Wang, AYM, Park, HC, Pickering, MC, Maruyama, S, Rathi, M, Nachman, PH, Fox, JG, Harris, D, Barratt, J, Hoxha, E, Johnson, DW, Trimarchi, H, Ayoub, I, Kitching, AR, Winkelmayer, WC, Fogo, AB   +67 more
core   +2 more sources

IKZF1 as a potential therapeutic target for dendritic cell-mediated immunotherapy in IgA nephropathy

Cell Communication and Signaling
Background Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis globally and a major cause of renal failure. Immune dysregulation drives its pathogenesis.
Fei Peng, Chunjia Sheng, Jiayi He, Yena Zhou, Yilun Qu, Shuwei Duan, Yinghua Zhao, Jikai Xia, Jie Wu, Guangyan Cai, Lingling Wu, Chuyue Zhang, Xiangmei Chen   +12 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Clinicopathological characteristics and renal outcomes of IgA nephropathy in systemic lupus erythematosus: a case report and systematic literature review

BMC Nephrology
Background Whether IgA nephropathy (IgAN) in patients with systemic lupus erythematosus (SLE) represents a coincidental comorbidity or a distinct clinico-pathological entity remains unclear.
XiXi Zhao, ZhenZhen Li, GuangYan Cai, FengKun Chen, Jian Zhang, XuanLi Tang, Xu Zhang, ZhiYu Duan, Yan Song   +8 more
doaj   +1 more source