Results 121 to 130 of about 994,467 (315)

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

Gut microbiota–derived short-chain fatty acids and kidney diseases

, 2017
Lingzhi Li, Liang Ma, Ping Fu Kidney Research Institute, Department of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, China Abstract: Gut microbiota and its metabolites play pivotal roles in host physiology and pathology.
Ma L, Li L, Fu P
core  

Protocol for Developing and Validating a Multimarker-Clinical Prediction Model of SGLT2 Inhibitor-Induced Acute eGFR Dip in CKD Stages 3–4: A Three-Stage Urinary Proteomics Study

Life
Introduction: SGLT2 inhibitors reduce renal composite endpoints and proteinuria, yet RCTs uniformly show an acute eGFR dip within 2 weeks to 2 months after initiation.
Zhiyu Duan, Youhe Gao, Mengjie Huang, Yanjun Liang, Jing Hao, Jie Wang, Guangyan Cai   +6 more
doaj   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

The kidney in systemic autoimmune diseases /

, 2008
This volume brings together an international group of clinicians and clinical scientists to contribute to a state-of the-art review of the underlying pathogenic mechanisms, methods of clinical assessment, classification and diagnosis of renal disease ...
Pusey, C. D., Mason, Justin C.
core  

Patterns of Kidney Function Decline in Autosomal Dominant Polycystic Kidney Disease: A Post Hoc Analysis From the HALT-PKD Trials

, 2018
Background: Previous clinical studies of autosomal dominant polycystic kidney disease (ADPKD) reported that loss of kidney function usually follows a steep and relentless course.
Rahbari-Oskoui, Frederic F., Theodore Steinman, Jesse Wei, Schrier, Robert, Torres, Vicente E., Czarnecki, Peter, Steinman, Theodore I., Torres, Vicente, Masoumi, Amirali, Perrone, Ronald D., Rocco, Michael, Dana C. Miskulin, Yu, Alan, William E. Braun, James E. Bost, Vicente Torres, Miskulin, Dana, Hogan, Marie C., Wetzel, Louis, Godela M. Brosnahan, Ronald Perrone, Greene, Tom, Abebe, Kaleab Z., James Glockner, Briggs, Josephine, Erick Remer, Kaleab Z. Abebe, Shayman, James, Patel, Nayana, Bost, James E., Michael F. Flessner, Mittal, Pardeep, Meyers, Catherine M., Berenice Gitomer, Nayana Patel, Harris, Peter C., Kyongtae T. Bae, Franz Winklhofer, Saul Nurko, Connie Wang, Bae, Kyongtae T., Josephine Briggs, Peter C. Harris, William Henrich, Henrich, William, Wendler, David, Marie C. Hogan, Glockner, James, Vicente E. Torres, Grantham, Jared J., Nurko, Saul, King, Bernard, Dana Miskulin, Chapman, Arlene B., Miskulin, Dana C., Kelleher, Cass, Peter Czarnecki, Miller, J. Philip, Kyongtae Bae, Moore, Charity G., Robert W. Schrier, Peter McCullough, Jared Grantham, Frederic F. Rahbari-Oskoui, Theodore I. Steinman, Amirali Masoumi, McCullough, Peter, Cass Kelleher, Winklhofer, Franz, Frederic Rahbari-Oskoui, Tom Greene, Martin, Diego, Leonard, Mary, Ivan Pedrosa, Ronald D. Perrone, Godela Brosnahan, Diego Martin, Star, Robert, William Braun, Robert Star, Moe, Sharon, Charity G. Moore, Mary Leonard, Gitomer, Berenice, El-Zoghby, Ziad, Wang, Connie, Chapman, Arlene, Bernard King, James Shayman, Arlene Chapman, Peter Harris, Halin, Neil, Brosnahan, Godela M., Thompson, Paul A., Jared J. Grantham, J. Philip Miller, Schrier, Robert W., Michael Flessner, Flessner, Michael F., Paul A. Thompson, Robert Schrier, Bae, Kyongtae, Braun, William E., Alan Yu, Louis Wetzel, Catherine M. Meyers, Neil Halin, Ziad El-Zoghby, Remer, Erick, Sharon Moe, David Wendler, Pedrosa, Ivan, Arlene B. Chapman, Pardeep Mittal, Wei, Jesse, Michael Rocco   +115 more
core   +1 more source

Kidney size and its correlation with demographics: a retrospective CT Scan-based study from Pakistan

The Egyptian Journal of Radiology and Nuclear Medicine
Background Kidney size is a critical parameter in the assessment of renal health, yet population-specific reference values are lacking for Pakistan. This study aimed to establish normative computed tomography (CT)-based renal dimensions and volumes in a ...
Muhammad Rashid Asghar, Faiza Mukhtar, Muhammad Shahzil, Wajahat Ali, Aimon Riaz, Ashar Yaqub, Ahmed Sheraz, Khuram Bashir, Nayyar Saleem   +8 more
doaj   +1 more source

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source

Acute kidney injury in Australia: a first national snapshot [PDF]

, 2015
Overview Acute kidney injury (AKI) is increasing in incidence globally. This report presents the first national statistical snapshot on AKI and its impact in Australia.
Australian Institute of Health and Welfare
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