Results 121 to 130 of about 1,448,860 (303)

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source

GENDER AND AGE DISTRIBUTION, AND URINARY METABOLIC ABNORMALITIES IN PATIENTS WITH RECURRENT URINARY TRACT STONES

Gomal Journal of Medical Sciences, 2015
Background: Urolithiasis is one of the most common urological disorders. Patients with recurrent urinary tract stones may have underlying metabolic abnormality. The objectives of this study were to determine the gender and age distribution, and frequency
Muhammad Naeem, Tariq Ahmad, Muhammad Kamran Khan, Hazrat Ullah   +3 more
doaj  

Kidney size and its correlation with demographics: a retrospective CT Scan-based study from Pakistan

The Egyptian Journal of Radiology and Nuclear Medicine
Background Kidney size is a critical parameter in the assessment of renal health, yet population-specific reference values are lacking for Pakistan. This study aimed to establish normative computed tomography (CT)-based renal dimensions and volumes in a ...
Muhammad Rashid Asghar, Faiza Mukhtar, Muhammad Shahzil, Wajahat Ali, Aimon Riaz, Ashar Yaqub, Ahmed Sheraz, Khuram Bashir, Nayyar Saleem   +8 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Clinical characteristics and prognostic factors of non-malignant pleural effusions in hospitalised patients: a retrospective cohort study

BMJ Open
Objective Non-malignant pleural effusions (NMPE) are common in hospitalised patients. Data on NMPE inpatients are scarce and the factors influencing the prognosis are unknown.Design This was a retrospective cohort study.Setting and participants We ...
Li Zhang, Ping Li, Xiangmei Chen, Xuefeng Sun, Li Tang, Yan Mei, Guangyan Cai, Yue Niu, Danni Wang, Yangyang Ma, Qingtao Zhang   +10 more
doaj   +1 more source

Cellular microRNA networks regulate host dependency of hepatitis C virus infection

Nature Communications, 2017
Using genome-wide miRNA mimic and hairpin inhibitor screens, Li et al. identify 31 miRNAs that either inhibit or promote hepatitis C virus (HCV) replication at different steps of the viral life cycle.
Qisheng Li, Brianna Lowey, Catherine Sodroski, Siddharth Krishnamurthy, Hawwa Alao, Helen Cha, Stephan Chiu, Ramy El-Diwany, Marc G. Ghany, T. Jake Liang   +9 more
doaj   +1 more source

Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons, Nuria Guillen, Jordi Sarto, Neus Falgàs, Sergi Borrego‐Écija, Diana Esteller‐Gauxax, Magda Castellví, Adrià Tort‐Merino, Agnès Pérez‐Millan, Anna Antonell, Josep M. Augè Fradera, Gerard Piñol, Iolanda Riba, Anna Carnes‐Vendrell, Marta Cullell, Maria Teresa Osuna, Lorena Bajo, Teresa Romero, Eva Bonjoch, Joan Bello, Susana Fernández, Marta Balagué, Isabel Gómez‐Ruiz, Anuncia Boltes, Claustre Pont, Raquel Cuevas, Sara Carrillo, Laura Iglesias, Teresa Maria Casadevall Codina, Lorena Grau Guinea, Fernando Jose Espada, Raquel Sánchez‐Valle, Mircea Balasa, Albert Lladó   +33 more
wiley   +1 more source

Francisella tularensis Transmission by Solid Organ Transplantation, 20171. [PDF]

, 2019
In July 2017, fever and sepsis developed in 3 recipients of solid organs (1 heart and 2 kidneys) from a common donor in the United States; 1 of the kidney recipients died.
Annambhotla, Pallavi, Asad, Shadaba, Aslam, Saima, Basavaraju, Sridhar V, Brown, Jennifer, Burns, Kevin, Carifo, Karen, Dagher, Hikmat N, Fritz, Curtis L, Gonzalez, Anthony, Ham, John, Helsel, Elizabeth, Hinckley, Alison F, Iser, Joseph, Johnson, Michael, Jones, Jefferson M, Kelley, Walter E, Kingry, Luke C, Krafft, Melissa, Kwit, Natalie A, Medina-Garcia, Luis H, Mohler, Kelli, Murua, Christian, Nelson, Christina A, Petersen, Jeannine M, Respicio-Kingry, Laurel, Tularemia in Transplant Recipients Investigation Team, Wiggins, Landon, Zhang, Ying   +28 more
core  

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source