Results 121 to 130 of about 14,135,306 (260)

Chronic kidney disease: regional variation in Australia [PDF]

, 2013
Chronic kidney disease (CKD) is a common and serious problem in Australia and its management can be resource intensive. Those with CKD\u27s most severe form, end-stage kidney disease (ESKD), usually require kidney replacement therapy (KRT) to ...

core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Shenhua Tablet inhibits mesangial cell proliferation in rats with chronic anti-Thy-1 nephritis

Biological Research
BACKGROUND: In China, mesangial proliferative glomerulonephritis (MsPGN) is one of the most common kidney diseases. In this study, we treated a rat model of chronic anti-Thy-1 MsPGN with Shenhua Tablet and evaluated whether the tablet was able to protect
Wenjia Geng, Ribao Wei, Shuwen Liu, Li Tang, Hanyu Zhu, Pu Chen, Jie Wu, Xueguang Zhang, Fei Zhu, Zhong Yin, Xiangmei Chen   +10 more
doaj  

Understanding autoimmune response after SARS-CoV-2 infection and the pathogenesis/mechanisms of long COVID

Medical Review
COVID-19 posed a major challenge to the healthcare system and resources worldwide. The popularization of vaccines and the adoption of numerous prevention and control measures enabled the gradual end of the COVID-19 pandemic.
Guo Ming, Shang Shunlai, Li Mengfei, Cai Guangyan, Li Ping, Chen Xiangmei, Li Qinggang   +6 more
doaj   +1 more source

Multifactorial functions of the inflammasome component NLRP3 in pathogenesis of chronic kidney diseases.

Kidney International, 2019
The NLRP3 inflammasome is a cytosolic multiprotein caspase-activating complex platform involved in innate immunity required for the maturation and release of interleukin (IL)-1β and IL-18.
S. R. Mulay
semanticscholar   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Exploration of rituximab treatment strategies for membranous nephropathy adapted to the Chinese healthcare environment

BMC Nephrology
Purpose This study aimed to explore the specific efficacy of rituximab (RTX) in the treatment of membranous nephropathy (MN) and compare and analyze the differences in effectiveness among various treatment regimens, with the objective of identifying the ...
Xiaolong Wang, Xueying Cao, Jie Wu, Shuang Liang, Jian Yang, Hong Wang   +5 more
doaj   +1 more source

Incidence and Prognosis of Acute Kidney Diseases and Disorders Using an Integrated Approach to Laboratory Measurements in a Universal Health Care System

JAMA Network Open, 2019
Key Points Question Do the acute kidney diseases and disorders (AKD) criteria from the Kidney Disease: Improving Global Outcomes guidelines identify patients who do not meet existing criteria for chronic kidney disease (CKD) or acute kidney injury (AKI),
M. James, A. Levey, M. Tonelli, Zhi Tan, Rebecca Barry, N. Pannu, P. Ravani, S. Klarenbach, B. Manns, B. Hemmelgarn   +9 more
semanticscholar   +1 more source

Chemokine receptor CCR1: A new target for progressive kidney disease [PDF]

, 2005
Infiltrating leukocytes are thought to contribute to the progression of kidney disease. Locally produced chemokines guide circulating leukocytes into the kidney, which renders therapeutic blockade of respective chemokine receptors on the leukocyte ...
Hans-Joachim Anders, Ninichuk, Volha, Anders, Hans-Joachim, Volha Ninichuk   +3 more
core   +1 more source