Results 111 to 120 of about 14,135,306 (260)

The Role of Sirtuins in Kidney Diseases

International Journal of Molecular Sciences, 2020
Sirtuins (SIRTs) are class III histone deacetylases (HDACs) that play important roles in aging and a wide range of cellular functions. Sirtuins are crucial to numerous biological processes, including proliferation, DNA repair, mitochondrial energy ...
Yu-Ah Hong, J. E. Kim, Jee-Jo Min, Gang J. Ko   +3 more
semanticscholar   +1 more source

CRISPR-Cas9 system in autosomal dominant polycystic kidney disease: a comprehensive review [PDF]

Genetic kidney diseases are caused by mutations in specific genes that significantly affect kidney development and function. Although the underlying pathogenic genes of many kidney diseases have been identified, an understanding of their mechanisms and ...
Andreas Kronbichler, Seungyeon Kang, Jae Il Shin, Lee, M. H., Kang, S., Kronbichler, Andreas, Shin, J. I., Se Jin Park, Min Ho Lee, Park, S. J., Kang, S.,, Park, S. J.,, Lee, M. H.,, Shin, J. I.,, Kronbichler, Andreas,   +14 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Progress in the study of aging marker criteria in human populations

Frontiers in Public Health
The use of human aging markers, which are physiological, biochemical and molecular indicators of structural or functional degeneration associated with aging, is the fundamental basis of individualized aging assessments.
Yan He, Yan He, Zhe Li, Yue Niu, Yuting Duan, Qian Wang, Xiaomin Liu, Zheyi Dong, Ying Zheng, Yizhi Chen, Yizhi Chen, Yong Wang, Delong Zhao, Xuefeng Sun, Guangyan Cai, Zhe Feng, Weiguang Zhang, Xiangmei Chen, Xiangmei Chen   +18 more
doaj   +1 more source

Clinical practice guideline for renal rehabilitation: systematic reviews and recommendations of exercise therapies in patients with kidney diseases

Renal Replacement Therapy, 2019
In recent years, a concept of renal rehabilitation has become widely known among nephrology specialists, dialysis specialists, kidney transplantation specialists, rehabilitation specialists, nutrition specialists, guideline specialists, nurses ...
K. Yamagata, J. Hoshino, H. Sugiyama, N. Hanafusa, Y. Shibagaki, Y. Komatsu, T. Konta, N. Fujii, E. Kanda, T. Sofue, K. Ishizuka, M. Kitagawa, K. Kono, Norikazu Hinamoto, Takayuki Miyai, Kiyomi Koike, S. Toda, J. Hasegawa, M. Yamanouchi, R. Yoshimura, Ryota Ishii, S. Goto, H. Kawarazaki, Kentaro Takase, Fumika Taki, Mimiko Matsumura, Y. Raita, Satoko Sakurai, Tatsuya Shimizu, Suguru Yamanoto, Takehiko Kawaguchi, H. Oguchi, M. Tsujita, M. Yazawa, A. Uchida, Yasuhiro Ando, S. Kaneko, A. Matsunaga, Taku Harada, O. Ito, M. Kohzuki   +40 more
semanticscholar   +1 more source

Gut microbiota–derived short-chain fatty acids and kidney diseases

, 2017
Lingzhi Li, Liang Ma, Ping Fu Kidney Research Institute, Department of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, China Abstract: Gut microbiota and its metabolites play pivotal roles in host physiology and pathology.
Ma L, Li L, Fu P
core  

Kidney Biopsy Findings and Management of Kidney Diseases in Patients with Class III Obesity: A Single-Center Experience

Background: Class III obesity, formerly known as morbid obesity, is a known risk factor for chronic kidney diseases. Due to outdated information suggesting that morbid obesity is a contraindication for kidney biopsy and the misconception that proteinuria
Rezzan Eren Sadioğlu, Saba Kiremitçi, Kenan Keven   +2 more
core   +1 more source

Endothelial Progenitor Cells and Kidney Diseases

, 2018
Endothelial progenitor cells (EPC) are bone marrow derived or tissue-resident cells that play major roles in the maintenance of vascular integrity and repair of endothelial damage.
Abdullah Ozkok, Alaattin Yildiz, Yildiz, Alaattin, Ozkok, Abdullah   +3 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Arterial stiffness is associated with handgrip strength in relatively healthy Chinese older adults

Frontiers in Nutrition
BackgroundIncreased arterial stiffness and low handgrip strength (HGS) are associated with poor health outcomes and are a severe health risk for older adults. However, there is limited evidence and mixed results on whether there is an association between
Yan He, Yan He, Yue Niu, Zhe Li, Ruimin Zhang, Ruimin Zhang, Yizhi Chen, Yizhi Chen, Zheyi Dong, Ying Zheng, Qian Wang, Yong Wang, Delong Zhao, Xuefeng Sun, Guangyan Cai, Zhe Feng, Weiguang Zhang, Xiangmei Chen, Xiangmei Chen   +18 more
doaj   +1 more source