Results 111 to 120 of about 3,539,187 (313)

IKZF1 as a potential therapeutic target for dendritic cell-mediated immunotherapy in IgA nephropathy

Cell Communication and Signaling
Background Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis globally and a major cause of renal failure. Immune dysregulation drives its pathogenesis.
Fei Peng, Chunjia Sheng, Jiayi He, Yena Zhou, Yilun Qu, Shuwei Duan, Yinghua Zhao, Jikai Xia, Jie Wu, Guangyan Cai, Lingling Wu, Chuyue Zhang, Xiangmei Chen   +12 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Endothelial Progenitor Cells and Kidney Diseases

, 2018
Endothelial progenitor cells (EPC) are bone marrow derived or tissue-resident cells that play major roles in the maintenance of vascular integrity and repair of endothelial damage.
Abdullah Ozkok, Alaattin Yildiz, Yildiz, Alaattin, Ozkok, Abdullah   +3 more
core   +1 more source

Clinicopathological characteristics and renal outcomes of IgA nephropathy in systemic lupus erythematosus: a case report and systematic literature review

BMC Nephrology
Background Whether IgA nephropathy (IgAN) in patients with systemic lupus erythematosus (SLE) represents a coincidental comorbidity or a distinct clinico-pathological entity remains unclear.
XiXi Zhao, ZhenZhen Li, GuangYan Cai, FengKun Chen, Jian Zhang, XuanLi Tang, Xu Zhang, ZhiYu Duan, Yan Song   +8 more
doaj   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Haptoglobin genotypes, inflammation status and their associations with hemoglobin levels in stage 4 chronic kidney disease patients with anemia [PDF]

Background and aims: Anemia and increased inflammation are the main causes of mortality in chronic kidney disease (CKD) patients. This study was designed to explore the probable relationship of hemoglobin (Hb) with serum haptoglobin (HP), its ...
ارگانی, حسن, حسینی اصل, سید سعید, علی پناه مقدم, رضا, قربانی حق جو, امیر   +3 more
core  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

DISEASES OF THE KIDNEY [PDF]

Annual Review of Medicine, 1954
E V, NEWMAN, D G, POCOCK
openaire   +2 more sources

World Kidney Day 2012: the global role of kidney transplantation.

, 2012
There remain major challenges to providing optimal treatment for ESRD worldwide and a need, particularly in low-income economies, to mandate more focus on community screening and implementation of simple measures to minimize progression of chronic kidney
Harden, P.N., García, G.G., Chapman, J.R.   +2 more
core   +1 more source