Results 91 to 100 of about 14,135,306 (260)

A novel mutation causing nephronophthisis in the Lewis polycystic kidney rat localises to a conserved RCC1 domain in Nek8 [PDF]

, 2012
Background Nephronophthisis (NPHP) as a cause of cystic kidney disease is the most common genetic cause of progressive renal failure in children and young adults.
Morahan, G., Mathew I Bellgard, Roberto A Barrero, Morahan, G, McCooke, J.K., Bellgard, MI, Jacqueline K Phillips, Ding, A., John K McCooke, Appels, R, Grant Morahan, Phillips, J.K., Justyna E Ozimek-Kulik, Phillips, JK, Bellgard, M.I., Barrero, RA, McCooke, JK, Appels, R., Barrero, R.A., Ozimek-Kulik, J.E., Rudi Appels, Alice Ding, Ozimek-Kulik, JE, Ding, A   +23 more
core   +1 more source

A role for genetic modifiers in tubulointerstitial kidney diseases

, 2023
With the increased availability of genomic sequencing technologies, the molecular bases for kidney diseases such as nephronophthisis and mitochondrially inherited and autosomal-dominant tubulointerstitial kidney diseases (ADTKD) has become increasingly ...
Leggatt, Gary P., Gilbert, Rodney, Ennis, Sarah, Sarah Ennis, Gast, Christine, Gary P. Leggatt, Eleanor G. Seaby, Seaby, Eleanor G., Veighey, Kristin, Kristin Veighey, Rodney D. Gilbert, Christine Gast   +11 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Severity of Acute Kidney Injury and its Effect on Outcome in Patients of Dengue Virus Infection

Pakistan Journal of Medical Research, 2021
Background: Dengue fever is a mosquito borne viral illness that has endangered a vast population of tropical and sub-tropical areas. Dengue has multi-system involvement including liver, hematological, respiratory and central nervous systems. Spectrum of
Muhammad Tanzeel Abbasi, Mariam Arif, Muhammad Nabeel Abbasi, Muhammad Nauman Hashmi, Muhammad Rashid Asghar, Khuram Bashir   +5 more
doaj   +2 more sources

Blood and urine biomarkers of disease progression in IgA nephropathy

Biomarker Research
The prognosis of patients with IgA nephropathy (IgAN) is variable but overall not good. Almost all patients with IgAN are at risk of developing end-stage renal disease within their expected lifetime.
Zhi-Yu Duan, Chun Zhang, Xiang-Mei Chen, Guang-Yan Cai   +3 more
doaj   +1 more source

Diagnostic and therapeutic potential of interleukin-37 in kidney diseases: A mini-review [PDF]

Interleukin-37 (IL-37) is a newly discovered anti-inflammatory cytokine from the IL-1 family that plays a key role in regulating both innate and adaptive immune responses.
Larysa Kuts, Svitlana Bokova, Nadiia Demikhova, Eda Merisalu, Olga Vlasenko   +4 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Urinary miR-142-3p: a novel biomarker of the progression of IgA nephropathy

Frontiers in Immunology
BackgroundThe prognosis of IgA nephropathy (IgAN) varies greatly but tends to be poor. The purpose of the present study was to screen for urinary sediment miRNAs that could be used for the non-invasive prediction of IgAN progression and to explore the ...
Zhi-Yu Duan, Meng Zhang, Ru Bu, Qiu-Yue Zhang, Jie Wu, ShuWei Duan, ShuPeng Lin, Xi-Zhao Chen, WenJuan Wang, Xiang-Mei Chen, Zhe Feng, Guang-Yan Cai   +11 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Machine learning model for cardiovascular disease prediction in patients with chronic kidney disease

Frontiers in Endocrinology
IntroductionCardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney disease (CKD). This study aimed to develop CVD risk prediction models using machine learning to support clinical decision making and improve patient ...
He Zhu, He Zhu, Shen Qiao, Shen Qiao, Delong Zhao, Keyun Wang, Bin Wang, Yue Niu, Shunlai Shang, Zheyi Dong, Weiguang Zhang, Ying Zheng, Xiangmei Chen   +12 more
doaj   +1 more source