Results 81 to 90 of about 1,448,860 (303)

Wars, disasters and kidneys [PDF]

, 2014
This paper summarizes the impact that wars had on the history of nephrology, both worldwide and in the Ghent Medical Faculty notably on the definition, research and clinical aspects of acute kidney injury.
Lameire, Norbert
core   +2 more sources

Diabetic Kidney Disease [PDF]

Clinical Journal of the American Society of Nephrology, 2017
Diabetic kidney disease (DKD) is a major cause of ESRD. Management includes prudent BP and glycemic control, nutritional counseling, and lifestyle modifications, including exercise, weight loss, and smoking cessation. Renin-angiotensin system (RAS) blockade using angiotensin-converting enzyme (ACE)
Lili, Tong, Sharon G, Adler
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Braden score for early mortality risk assessment in critically ill intensive care patients with multiple organ dysfunction syndrome 

Scientific Reports
Multiple organ dysfunction syndrome (MODS) is a clinical syndrome characterized by the simultaneous or sequential dysfunction of two or more organs. This condition can result in prolonged hospital stays, high in-hospital mortality rates, and an increased
Weizhu Deng, Ximu Zhang, Xiaoli Liu, Qian Wang, Chao Liu, Sha Luo, Qihu Li, Yuwei Ji, Wang Lu, Quan Hong, Zhe Feng, Guangyan Cai, Wei Yan, Zheyi Dong   +13 more
doaj   +1 more source

Progress in the study of aging marker criteria in human populations

Frontiers in Public Health
The use of human aging markers, which are physiological, biochemical and molecular indicators of structural or functional degeneration associated with aging, is the fundamental basis of individualized aging assessments.
Yan He, Yan He, Zhe Li, Yue Niu, Yuting Duan, Qian Wang, Xiaomin Liu, Zheyi Dong, Ying Zheng, Yizhi Chen, Yizhi Chen, Yong Wang, Delong Zhao, Xuefeng Sun, Guangyan Cai, Zhe Feng, Weiguang Zhang, Xiangmei Chen, Xiangmei Chen   +18 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Arterial stiffness is associated with handgrip strength in relatively healthy Chinese older adults

Frontiers in Nutrition
BackgroundIncreased arterial stiffness and low handgrip strength (HGS) are associated with poor health outcomes and are a severe health risk for older adults. However, there is limited evidence and mixed results on whether there is an association between
Yan He, Yan He, Yue Niu, Zhe Li, Ruimin Zhang, Ruimin Zhang, Yizhi Chen, Yizhi Chen, Zheyi Dong, Ying Zheng, Qian Wang, Yong Wang, Delong Zhao, Xuefeng Sun, Guangyan Cai, Zhe Feng, Weiguang Zhang, Xiangmei Chen, Xiangmei Chen   +18 more
doaj   +1 more source

Changes in kidney function in a population with essential hypertension in real life settings [PDF]

, 2017
Introduction. Hypertension has been identified as one of the commonest modifiable determinants for chronic kidney disease progression. A variety of antihypertensive drugs are available and their effect on kidney function has been investigated by a ...
Haidich, Anna-Bettina, Lasaridis, Anastasios N., Mark, Patrick B., Pikilidou, Maria I., Ptinopoulou, Anastasia G., Tziolas, Ioannis M., Zebekakis, Pantelis E.   +6 more
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Exploration of rituximab treatment strategies for membranous nephropathy adapted to the Chinese healthcare environment

BMC Nephrology
Purpose This study aimed to explore the specific efficacy of rituximab (RTX) in the treatment of membranous nephropathy (MN) and compare and analyze the differences in effectiveness among various treatment regimens, with the objective of identifying the ...
Xiaolong Wang, Xueying Cao, Jie Wu, Shuang Liang, Jian Yang, Hong Wang   +5 more
doaj   +1 more source