Results 81 to 90 of about 3,539,187 (313)

Metabolic syndrome, the leptin gene and kidney disease in non-diabetic black South Africans [PDF]

, 2008
Includes abstract.Includes bibliographical references (leaves 226-256).Obesity is a worldwide problem and is a factor in the pathogenesis of the metabolic syndrome and kidney disease through the development of obesity-related hypertension and ...
Okpechi, Ikechi Gareth
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Kidney Aging and Chronic Kidney Disease

International Journal of Molecular Sciences
The process of aging inevitably leads to an increase in age-related comorbidities, including chronic kidney disease (CKD). In many aspects, CKD can be considered a state of accelerated and premature aging. Aging kidney and CKD have numerous common characteristic features, ranging from pathological presentation and clinical manifestation to underlying ...
Zhang, Yingying, Yu, Chen, Li, Xiaogang
openaire   +2 more sources

Deciphering the Genetic Code of Autoimmune Kidney Diseases

, 2023
Autoimmune kidney diseases occur due to the loss of tolerance to self-antigens, resulting in inflammation and pathological damage to the kidneys. This review focuses on the known genetic associations of the major autoimmune kidney diseases that result in
Kim Maree O’Sullivan, Oneli Kulatunge, Stephanie U-Shane Huang   +2 more
core   +1 more source

Braden score for early mortality risk assessment in critically ill intensive care patients with multiple organ dysfunction syndrome 

Scientific Reports
Multiple organ dysfunction syndrome (MODS) is a clinical syndrome characterized by the simultaneous or sequential dysfunction of two or more organs. This condition can result in prolonged hospital stays, high in-hospital mortality rates, and an increased
Weizhu Deng, Ximu Zhang, Xiaoli Liu, Qian Wang, Chao Liu, Sha Luo, Qihu Li, Yuwei Ji, Wang Lu, Quan Hong, Zhe Feng, Guangyan Cai, Wei Yan, Zheyi Dong   +13 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Monogenic Kidney Diseases in Kidney Transplantation

Kidney International Reports
Monogenic kidney diseases are involved in up to 15% of end-stage kidney diseases (ESKDs) in adults, and in 70 % of pediatric patients. When these disorders lead to kidney failure (KF), kidney transplantation (KT) is the preferred mode of replacement therapy.
Gillion, Valentine, Devresse, Arnaud, Olinger, Eric, Dahlqvist, Géraldine, Demoulin, Nathalie, Godefroid, Nathalie, Claes, Kathleen, Devuyst, Olivier, Kanaan, Nada   +8 more
openaire   +3 more sources

Progress in the study of aging marker criteria in human populations

Frontiers in Public Health
The use of human aging markers, which are physiological, biochemical and molecular indicators of structural or functional degeneration associated with aging, is the fundamental basis of individualized aging assessments.
Yan He, Yan He, Zhe Li, Yue Niu, Yuting Duan, Qian Wang, Xiaomin Liu, Zheyi Dong, Ying Zheng, Yizhi Chen, Yizhi Chen, Yong Wang, Delong Zhao, Xuefeng Sun, Guangyan Cai, Zhe Feng, Weiguang Zhang, Xiangmei Chen, Xiangmei Chen   +18 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Kidney diseases. Advances in diagnosis and treatment. III.Hereditary kidney diseases and others. Polycystic kidney disease.

Nihon Naika Gakkai Zasshi, 1996
多発性嚢胞腎には,常染色体優性多発性嚢胞腎(ADPKD)と常染色体劣性多発性嚢胞腎(ARPKD)がある. ADPKDは,多発性の腎嚢胞が出現し,腎機能が進行性に低下することと,頭蓋内出血が生命を脅かす主要な病態である. ADPKDの遺伝子異常には少なくとも二つの異なった部位が知られている. PKD1は腎機能の予後,嚢胞の程度がPKD2より厳しい.第16番染色体短腕にPKD1が同定され, PKD1蛋白は, 11回細胞膜を貫いて存在する糖蛋白で,細胞細胞間,あるいは細胞マトリックス間の結合に関与していることが推測されている.第4番染色体長腕上にPKD2の遺伝子が同定され,その蛋白は刺激伝達系に関与していることが推測されている.
openaire   +2 more sources