Results 81 to 90 of about 994,467 (315)

Deciphering the Genetic Code of Autoimmune Kidney Diseases

, 2023
Autoimmune kidney diseases occur due to the loss of tolerance to self-antigens, resulting in inflammation and pathological damage to the kidneys. This review focuses on the known genetic associations of the major autoimmune kidney diseases that result in
Kim Maree O’Sullivan, Oneli Kulatunge, Stephanie U-Shane Huang   +2 more
core   +1 more source

Computational genomics approaches for kidney diseases in Africa [PDF]

, 2015
Philosophiae Doctor - PhDEnd stage renal disease (ESRD), a more severe form of kidney disease, is considered to be a complex trait that may involve multiple processes which work together on a background of a significant genetic susceptibility.
Mapiye, Darlington Shingirirai
core   +1 more source

Progress in the study of aging marker criteria in human populations

Frontiers in Public Health
The use of human aging markers, which are physiological, biochemical and molecular indicators of structural or functional degeneration associated with aging, is the fundamental basis of individualized aging assessments.
Yan He, Yan He, Zhe Li, Yue Niu, Yuting Duan, Qian Wang, Xiaomin Liu, Zheyi Dong, Ying Zheng, Yizhi Chen, Yizhi Chen, Yong Wang, Delong Zhao, Xuefeng Sun, Guangyan Cai, Zhe Feng, Weiguang Zhang, Xiangmei Chen, Xiangmei Chen   +18 more
doaj   +1 more source

Kidney diseases. Advances in diagnosis and treatment. III.Hereditary kidney diseases and others. Polycystic kidney disease.

Nihon Naika Gakkai Zasshi, 1996
多発性嚢胞腎には,常染色体優性多発性嚢胞腎(ADPKD)と常染色体劣性多発性嚢胞腎(ARPKD)がある. ADPKDは,多発性の腎嚢胞が出現し,腎機能が進行性に低下することと,頭蓋内出血が生命を脅かす主要な病態である. ADPKDの遺伝子異常には少なくとも二つの異なった部位が知られている. PKD1は腎機能の予後,嚢胞の程度がPKD2より厳しい.第16番染色体短腕にPKD1が同定され, PKD1蛋白は, 11回細胞膜を貫いて存在する糖蛋白で,細胞細胞間,あるいは細胞マトリックス間の結合に関与していることが推測されている.第4番染色体長腕上にPKD2の遺伝子が同定され,その蛋白は刺激伝達系に関与していることが推測されている.
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The Value of Genetic Testing in Polycystic Kidney Diseases Illustrated by a Family With PKD2 and COL4A1 Mutations

, 2018
The diagnosis of autosomal dominant polycystic kidney disease (ADPKD) relies on imaging criteria in the setting of a positive familial history. Molecular analysis, seldom used in clinical practice, identifies a causative mutation in >90% of cases in the ...
Robert C. Albright, Senum, Sarah R., Harris, Peter C., Brendan C. Lanpher, Torres, Vicente E., Kyongtae T. Bae, Lanpher, Brendan C., Cornec-Le Gall, Emilie, Theodore I. Steinman, Steinman, Theodore I., Perrone, Ronald D., William E. Braun, Bae, Kyongtae T., Peter C. Harris, Schrier, Robert W., Chebib, Fouad T., Charles D. Madsen, Alan S. Yu, Marc C. Patterson, Vicente E. Torres, Ronald D. Perrone, Madsen, Charles D., Chapman, Arlene B., Patterson, Marc C., Abebe, Kaleab Z., Christina M. Heyer, Heyer, Christina M., Braun, William E., Kaleab Z. Abebe, Robert W. Schrier, Albright, Robert C., Sarah R. Senum, Yu, Alan S., Arlene B. Chapman, Emilie Cornec-Le Gall, Fouad T. Chebib   +35 more
core   +1 more source

Clinical Implication of Heat Shock Protein 70 in Kidney Disease Kidney Diseases and HSP70

, 2021
Heat shock protein (HSP) 70 has been investigated from various aspects in experimental studies, since it is the most abundant form of HSP in cells. HSP 70 is involved in response to various acute and chronic insults of kidney and also other parts of the ...
Yilmaz, Alev, Yildirim, Zeynep Nagehan Yuruk   +1 more
core   +1 more source

Arterial stiffness is associated with handgrip strength in relatively healthy Chinese older adults

Frontiers in Nutrition
BackgroundIncreased arterial stiffness and low handgrip strength (HGS) are associated with poor health outcomes and are a severe health risk for older adults. However, there is limited evidence and mixed results on whether there is an association between
Yan He, Yan He, Yue Niu, Zhe Li, Ruimin Zhang, Ruimin Zhang, Yizhi Chen, Yizhi Chen, Zheyi Dong, Ying Zheng, Qian Wang, Yong Wang, Delong Zhao, Xuefeng Sun, Guangyan Cai, Zhe Feng, Weiguang Zhang, Xiangmei Chen, Xiangmei Chen   +18 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

World Kidney Day 2012: the global role of kidney transplantation.

, 2012
There remain major challenges to providing optimal treatment for ESRD worldwide and a need, particularly in low-income economies, to mandate more focus on community screening and implementation of simple measures to minimize progression of chronic kidney
Harden, P.N., García, G.G., Chapman, J.R.   +2 more
core   +1 more source