Results 71 to 80 of about 3,539,187 (313)

Pruritus in Kidney Disease [PDF]

Seminars in Nephrology, 2015
Pruritus is a common and distressing symptom in patients with chronic kidney disease. The most recent epidemiologic data have suggested that approximately 40% of patients with end-stage renal disease experience moderate to severe pruritus and that uremic pruritus (UP) has a major clinical impact, being associated strongly with poor quality of life ...
Sara A, Combs, J Pedro, Teixeira, Michael J, Germain   +2 more
openaire   +2 more sources

Mesangioproliferative Kidney Diseases and Platelet-Derived Growth Factor-Mediated AXL Phosphorylation

, 2021
Rationale & Objective: Immunoglobulin A nephropathy (IgAN) is a common glomerular disease, with mesangial cell proliferation as a major feature. There is no disease-specific treatment. Platelet-derived growth factor (PDGF) contributes to the pathogenesis
Ebefors, Kerstin,, Bian, Q., Nyström, Jenny,, Julian, B. A., Willey, C. D., Anderson, J. C., Hall, S., Novak, L., Zhang, X. W., Novak, J., Huang, Z. Q.   +10 more
core   +1 more source

Polycystic Kidney Disease [PDF]

The Journal of Clinical Hypertension, 2005
Polycystic kidney disease, an inherited systemic disorder, is characterized by the development of multiple cysts in the kidneys and other organs. Patients can present at any age, but more often come to clinical attention (unless there is a family history) after age 30. Patients who are diagnosed before age 30 have a worse renal survival.
Pamela J, Fall, L Michael, Prisant
openaire   +2 more sources

Pregnancy and Kidney Outcomes in Patients With IgA Nephropathy: A Cohort Study

, 2017
Background: The outcomes of pregnancy in immunoglobulin A nephropathy (IgAN) are controversial. This cohort study assessed the effects of pregnancy on kidney disease progression and risk factors for adverse pregnancy outcomes in patients with IgAN ...
Xiaole Su, Liu, Youxia, Zhang, Hong, Jinwei Wang, Liu, Lijun, Ma, Xinxin, Jicheng Lv, Sufang Shi, Youxia Liu, Shi, Sufang, Wang, Jinwei, Lv, Jicheng, Xinxin Ma, Lijun Liu, Hong Zhang, Su, Xiaole   +15 more
core   +1 more source

Urinary miR-142-3p: a novel biomarker of the progression of IgA nephropathy

Frontiers in Immunology
BackgroundThe prognosis of IgA nephropathy (IgAN) varies greatly but tends to be poor. The purpose of the present study was to screen for urinary sediment miRNAs that could be used for the non-invasive prediction of IgAN progression and to explore the ...
Zhi-Yu Duan, Meng Zhang, Ru Bu, Qiu-Yue Zhang, Jie Wu, ShuWei Duan, ShuPeng Lin, Xi-Zhao Chen, WenJuan Wang, Xiang-Mei Chen, Zhe Feng, Guang-Yan Cai   +11 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

MSCs-derived HGF alleviates senescence by inhibiting unopposed mitochondrial fusion-based elongation in post-acute kidney injury

Stem Cell Research & Therapy
Background The underlying mechanism of human umbilical-derived mesenchymal stem cells (hUC-MSCs) therapy for renal senescence in post-acute kidney injury (post-AKI) remains unclear.
Kaiting Zhuang, Wenjuan Wang, Xumin Zheng, Xinru Guo, Cheng Xu, Xuejing Ren, Wanjun Shen, Qiuxia Han, Zhe Feng, Xiangmei Chen, Guangyan Cai   +10 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Effect of Statins on Kidney Disease Outcomes: A Systematic Review and Meta-analysis

, 2016
Background: The effects of statin administration on kidney disease outcomes remain controversial. We undertook a systematic review and meta-analysis to assess the efficacy of statins on kidney outcomes.
Hou, Wanyin, Zhang, Lu, Xie, Xinfang, Wang, Jinwei, Zhang, Hong, Lv, Jicheng, Su, Xiaole   +6 more
core   +1 more source

Hepatitis B and C co-Infection are independent predictors of progressive kidney disease in HIV-positive, antiretroviral-treated adults [PDF]

, 2012
Chronic kidney disease (CKD) is an important cause of morbidity and mortality in HIV-positive individuals. Hepatitis C (HCV) co-infection has been associated with increased risk of CKD, but prior studies lack information on potential mechanisms.
Bickel, M, ESPRIT Study Group, Amanda Mocroft, Christina M Wyatt, Ross, Michael J., Aleksandra Szymczak, ESPRIT Study Group, Daniel Grint, Jens Lundgren, Ryom, Lene, Lene Ryom, Neuhaus, Jacqueline, Bickel, Markus, Szymczak, A, Peters, L, Jacqueline Neuhaus, Ross, MJ, Michael J Ross, Koirala, J, Neuhaus, J, Szymczak, Aleksandra, Mocroft, Amanda, Peters, Lars, Grint, D, Markus Bickel, Grint, Daniel, Wyatt, CM, Janak Koirala, INSIGHT SMART Study Group, Lundgren, Jens, Ross, Michael J, Koirala, Janak, Ryom, L, Mocroft, A, Lars Peters, Lundgren, J, Wyatt, Christina M, Wyatt, Christina M.   +37 more
core   +1 more source