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Humoral and Cellular Immunogenicity of 3 Doses of BNT162b2 in Children With Kidney Diseases
, 2023 IntroductionPatients with severe kidney diseases are at risk of complications from COVID-19; however, little is known about the effectiveness of COVID-19 vaccines in children and adolescents with kidney diseases.MethodsWe investigated the immunogenicity ...
Wong, Howard HW +49 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Severity of Acute Kidney Injury and its Effect on Outcome in Patients of Dengue Virus Infection
Pakistan Journal of Medical Research, 2021 Background: Dengue fever is a mosquito borne viral illness that has endangered a vast population of tropical and sub-tropical areas. Dengue has multi-system involvement including liver, hematological, respiratory and central nervous systems. Spectrum of
Muhammad Tanzeel Abbasi +5 more
doaj +2 more sources
A new perspective on proteinuria and drug therapy for diabetic kidney disease
Frontiers in PharmacologyDiabetic kidney disease (DKD) is one of the leading causes of end-stage renal disease worldwide and significantly increases the risk of premature death due to cardiovascular diseases.
Ruimin Zhang +8 more
doaj +1 more source
Nephron Clinical Practice, 2012 Rare kidney diseases are a unique subset of renal disorders that are often termed ‘orphan’ as a result of a multitude of reasons: the small number of patients with the consequent lack of well-defined natural history and course of many of these diseases, limited awareness among the medical community, and finally the significant cost of developing novel ...
openaire +2 more sources
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Recent Advances in Molecular Mechanisms Underlying Kidney Diseases
Kidney diseases remain a major public health concern associated with increasing morbidity and the mortality of millions of people globally. Recently, the prevalence of kidney diseases has increased significantly.
core +1 more source
Chemokine receptor CCR1: A new target for progressive kidney disease [PDF]
, 2005 Infiltrating leukocytes are thought to contribute to the progression of kidney disease. Locally produced chemokines guide circulating leukocytes into the kidney, which renders therapeutic blockade of respective chemokine receptors on the leukocyte ...
Hans-Joachim Anders +3 more
core +1 more source
TOTAL ULTRASOUND GUIDED PERCUTANEOUS NEPHROLITHOTOMY: A NOVEL TECHNIQUE
Gomal Journal of Medical Sciences, 2014 Introduction: Fluoroscopy is commonly used imaging technique during percutaneous nephrolithotomy but is associated with risks of radiation exposure. We evaluated the safety and efficacy of ultrasound guided Percutaneous Nephrolithotomy for treatment of ...
Anayat Ullah +5 more
doaj
Blood and urine biomarkers of disease progression in IgA nephropathy
Biomarker ResearchThe prognosis of patients with IgA nephropathy (IgAN) is variable but overall not good. Almost all patients with IgAN are at risk of developing end-stage renal disease within their expected lifetime.
Zhi-Yu Duan +3 more
doaj +1 more source