Results 51 to 60 of about 952,825 (268)

A new perspective on proteinuria and drug therapy for diabetic kidney disease

Frontiers in Pharmacology
Diabetic kidney disease (DKD) is one of the leading causes of end-stage renal disease worldwide and significantly increases the risk of premature death due to cardiovascular diseases.
Ruimin Zhang, Ruimin Zhang, Qian Wang, Yaqing Li, Qihu Li, Xuefeng Zhou, Xiangmei Chen, Xiangmei Chen, Zheyi Dong   +8 more
doaj   +1 more source

Orphan Kidney Diseases [PDF]

Nephron Clinical Practice, 2012
Rare kidney diseases are a unique subset of renal disorders that are often termed ‘orphan’ as a result of a multitude of reasons: the small number of patients with the consequent lack of well-defined natural history and course of many of these diseases, limited awareness among the medical community, and finally the significant cost of developing novel ...
openaire   +2 more sources

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Urinary miR-142-3p: a novel biomarker of the progression of IgA nephropathy

Frontiers in Immunology
BackgroundThe prognosis of IgA nephropathy (IgAN) varies greatly but tends to be poor. The purpose of the present study was to screen for urinary sediment miRNAs that could be used for the non-invasive prediction of IgAN progression and to explore the ...
Zhi-Yu Duan, Meng Zhang, Ru Bu, Qiu-Yue Zhang, Jie Wu, ShuWei Duan, ShuPeng Lin, Xi-Zhao Chen, WenJuan Wang, Xiang-Mei Chen, Zhe Feng, Guang-Yan Cai   +11 more
doaj   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Braden score for early mortality risk assessment in critically ill intensive care patients with multiple organ dysfunction syndrome 

Scientific Reports
Multiple organ dysfunction syndrome (MODS) is a clinical syndrome characterized by the simultaneous or sequential dysfunction of two or more organs. This condition can result in prolonged hospital stays, high in-hospital mortality rates, and an increased
Weizhu Deng, Ximu Zhang, Xiaoli Liu, Qian Wang, Chao Liu, Sha Luo, Qihu Li, Yuwei Ji, Wang Lu, Quan Hong, Zhe Feng, Guangyan Cai, Wei Yan, Zheyi Dong   +13 more
doaj   +1 more source

Machine learning model for cardiovascular disease prediction in patients with chronic kidney disease

Frontiers in Endocrinology
IntroductionCardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney disease (CKD). This study aimed to develop CVD risk prediction models using machine learning to support clinical decision making and improve patient ...
He Zhu, He Zhu, Shen Qiao, Shen Qiao, Delong Zhao, Keyun Wang, Bin Wang, Yue Niu, Shunlai Shang, Zheyi Dong, Weiguang Zhang, Ying Zheng, Xiangmei Chen   +12 more
doaj   +1 more source

Kidney Aging and Chronic Kidney Disease

International Journal of Molecular Sciences
The process of aging inevitably leads to an increase in age-related comorbidities, including chronic kidney disease (CKD). In many aspects, CKD can be considered a state of accelerated and premature aging. Aging kidney and CKD have numerous common characteristic features, ranging from pathological presentation and clinical manifestation to underlying ...
Zhang, Yingying, Yu, Chen, Li, Xiaogang
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source