Results 11 to 20 of about 11,405,950 (406)
Immunological Reviews, 2022 SummaryDysregulation and accelerated activation of the alternative pathway (AP) of complement is known to cause or accentuate several pathologic conditions in which kidney injury leads to the appearance of hematuria and proteinuria and ultimately to the development of chronic renal failure.
Erica Daina +2 more
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Pyroptosis: A New Frontier in Kidney Diseases
Oxidative Medicine and Cellular Longevity, 2021 Pyroptosis is a pattern of programmed cell death that significantly differs from apoptosis and autophagy in terms of cell morphology and function. The process of pyroptosis is characterized predominantly by the formation of gasdermin protein family ...
Ke-jia Zhang +8 more
semanticscholar +1 more source
Mesenchymal stem cells and extracellular vesicles in therapy against kidney diseases
Stem cell research & therapeutics, 2021 Kidney diseases pose a threat to human health due to their rising incidence and fatality rate. In preclinical and clinical studies, it has been acknowledged that mesenchymal stem cells (MSCs) are effective and safe when used to treat kidney diseases ...
Yuling Huang, Lina Yang
semanticscholar +1 more source
Kidney age, not kidney disease [PDF]
Canadian Medical Association Journal, 2018 KEY POINTS Although a variety of conditions and syndromes may affect the kidneys over either chronic or acute time frames, the term “chronic kidney disease” (CKD) is used to describe a decrease in the filtration ability of the glomerular capillaries in the kidney.
Stevens, Richard J +10 more
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Kidney: polycystic kidney disease [PDF]
WIREs Developmental Biology, 2014 Polycystic kidney disease (PKD) is a life‐threatening genetic disorder characterized by the presence of fluid‐filled cysts primarily in the kidneys. PKD can be inherited as autosomal recessive (ARPKD) or autosomal dominant (ADPKD) traits. Mutations in either the PKD1 or PKD2 genes, which encode polycystin 1 and polycystin 2, are the underlying cause of
Binu M, Paul, Gregory B, Vanden Heuvel
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Bone Disease in Chronic Kidney Disease and Kidney Transplant
Nutrients, 2022 Chronic Kidney Disease–Mineral and Bone Disorder (CKD-MBD) comprises alterations in calcium, phosphorus, parathyroid hormone (PTH), Vitamin D, and fibroblast growth factor-23 (FGF-23) metabolism, abnormalities in bone turnover, mineralization, volume, linear growth or strength, and vascular calcification leading to an increase in bone fractures and ...
Bellorin-Font, Ezequiel +2 more
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Clinical Kidney Journal, 2021 Inherited kidney diseases (IKDs) are among the leading causes of early-onset chronic kidney disease (CKD) and are responsible for at least 10–15% of cases of kidney replacement therapy (KRT) in adults.
R. Torra, M. Furlano, A. Ortiz, E. Ars
semanticscholar +1 more source
Targeted Drug Delivery Systems for Kidney Diseases
Frontiers in Bioengineering and Biotechnology, 2021 Kidney diseases have gradually become a global health burden. Along with the development of nanotechnology, many hybrids or nanomaterials have been utilized to promote treatment efficiency with negligible side effects.
Xiaohan Huang +4 more
semanticscholar +1 more source
Frontiers in Immunology, 2015 CD74 (invariant MHC class II) regulates protein trafficking and is a receptor for macrophage migration inhibitory factor (MIF) and d-dopachrome tautomerase (d-DT/MIF-2). CD74 expression is increased in tubular cells and/or glomerular podocytes and parietal cells in human metabolic nephropathies, polycystic kidney disease, graft rejection and kidney ...
Lara eValiño-Rivas +7 more
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Is “chronic kidney disease” a disease? [PDF]
Journal of Evaluation in Clinical Practice, 2018 AbstractSeveral philosophers of medicine have attempted to answer the question “what is disease?” In current clinical practice, an umbrella term “chronic kidney disease” (CKD) encompasses a wide range of kidney health states from commonly prevalent subclinical, asymptomatic disease to rare end‐stage renal disease requiring transplant or dialysis to ...
Smart, B, Stevens, R, Verbakel, J
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