Results 241 to 250 of about 857,514 (313)

Reengineering Endogenous Targeting Lipid Nanoparticles (ENDO) for Systemic Delivery of mRNA to Pancreas

open access: yesAdvanced Materials, EarlyView.
ENDO lipid nanoparticles containing cholecalciferol as a fifth component demonstrate mRNA delivery to the pancreas with 99% selectivity, including beta cells. This platform shows minimal toxicity and sustained protein expression for up to 3 days in a dose‐dependent manner, offering a novel approach to pancreas‐specific mRNA delivery and gene therapy ...
Ivan Isaac   +7 more
wiley   +1 more source

Carbon Quantum Dots Assisted Virus Tracking: From Skin to Brain

open access: yesAdvanced Materials, EarlyView.
A novel carbon quantum dots‐dissolvable microneedle, CQDs‐dMN system, enables painless delivery and real‐time tracking of HSV‐1. The HSV‐1 is labeled with fluorescent CQDs and delivered to the skin dermis, minimizing damage compared to traditional methods.
Yaxiu Feng   +11 more
wiley   +1 more source

Polymer Nanogels with Albumin Reporting Interface Created Using RAFT Precipitation Polymerization for Disease Diagnosis and Food Testing

open access: yesAdvanced Materials Interfaces, EarlyView.
Herein, polymer nanogels with a reporting interface for albumin are synthesized through reversible addition–fragmentation chain transfer (RAFT) precipitation polymerization of di(ethylene glycol) methyl ether methacrylate and N,N’‐methylenebis(acrylamide) using a poly(2‐methacryloyloxyethyl phosphorylcholine) macro‐RAFT agent, followed by dansyl ...
Yukiya Kitayama   +2 more
wiley   +1 more source

Red Blood Cell Membrane‐Camouflaged Red Phosphorus‐Modified C3N4 for Enhanced Tumoral Photodynamic Therapy

open access: yesAdvanced Materials Interfaces, EarlyView.
Photodynamic therapy (PDT) faces clinical challenges due to poor tumor targeting and systemic toxicity. Herein, a biomimetic C3N4‐RP@RBCm nanoplatform is developed via erythrocyte membrane encapsulation, enabling CD47‐mediated immune evasion and EPR‐driven tumor accumulation.
Jiaxiu Liu   +9 more
wiley   +1 more source

A High‐Throughput AngioPlate Platform with Integrated AngioTEER for Modeling and Monitoring Renal Proximal Tubule Injury

open access: yesAdvanced Materials Technologies, EarlyView.
Renal tubular injury is a major contributor to kidney disease, yet remains poorly understood due to the lack of predictive models. This study presents a high‐throughput 3D renal proximal tubule model on the AngioPlate platform integrated with automated TEER measurements (AngioTEER), enabling real‐time monitoring of drug‐induced nephrotoxicity ...
Shravanthi Rajasekar   +13 more
wiley   +1 more source

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