Results 231 to 240 of about 14,135,306 (260)

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

WCN24-922 FRACTIONATED PLASMA SEPARATION AND ADSORPTION INTEGRATED WITH CONTINUOUS VENO-VENOUS HEMOFILTRATION IN PATIENTS WITH ACUTE BIPYRIDINE HERBICIDE POISONING

Kidney International Reports
Jianhua Dong, Xi Yang, Bian WU, Chuan Li, Li Huang, Yongchun Ge   +5 more
doaj   +1 more source

Concerted Action of Targeted Nucleic Acid Therapeutics as Flexible, Precision and Personalized Cancer Treatment

Advanced Science, EarlyView.
Combinations of small activating RNAs and small interfering RNAs were developed as personalized precision therapies that simultaneously activate tumor suppressors and silence oncogenes according to the molecular signatures of patient tumors. This combination strategy demonstrated superior anticancer efficacy, highlighting the promise of precision ...
Jing Wu, Jiaxuan Chen, Abdechakour Elkihel, Wenjun Lan, Nicolas Fraunhoffer, Dandan Zhu, Baoping Lian, Christina Galanakou, Zhancun Bian, Xi Liu, Odile Gayet, Loic Moubri, Julie Aglietti Roques, Vikash Reebye, Nagy Habib, Xiaoxuan Liu, Nelson Dusetti, Juan Lucio Iovanna, Ling Peng   +18 more
wiley   +1 more source

Toward Personalized Theranostics: A Modular PET Platform for Antibody‐Based Imaging and Therapy

Advanced Science, EarlyView.
This modular, site‐specific antibody platform enables customizable conjugates for PET imaging and therapy. Interchangeable payloads – including radiometals, cytotoxics, and fluorophores – support adaptable, multimodal applications with limited off‐target effects. In vivo, the DFO/DOTAGA bischelate immunoconjugate provided clear tumor delineation in PET/
Delphine Vivier, Megane Grah Kple, Julen Ariztia, Marion Leroux, Mathieu Moreau, Michael Claron, Maxime Cheveau, Adam Laouafa, Agnieszka Kownacka, Camille Petitot, John Simonet, Alexandre M. M. Dias, Sophie Poty, Charles Truillet, Bertrand Collin, Alexandra Oudot, Franck Denat   +16 more
wiley   +1 more source

Design and Application of Nanozymes: Current Trends and Cutting‐Edge Breakthroughs

Advanced Science, EarlyView.
Kelong Fan, Hui Wei, Xiyun Yan
wiley   +1 more source

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Pharmacological potential of Astragali Radix for the treatment of kidney diseases.

Phytomedicine, 2023
BACKGROUND With the increasing prevalence of hypertension, diabetes, and obesity, the incidence of kidney diseases is also increasing, resulting in a serious public burden.
Yue Shi, Xiu-Jie Shi, Mingming Zhao, Si-Jia Ma, Yu Zhang   +4 more
semanticscholar   +1 more source

Nutrient-sensing mTORC1 and AMPK pathways in chronic kidney diseases

Nature Reviews Nephrology, 2022
C. Huynh, J. Ryu, Jooho Lee, Ayaka Inoki, K. Inoki   +4 more
semanticscholar   +1 more source

Urine Metabolic Fingerprints Encode Subtypes of Kidney Diseases.

Angewandte Chemie, 2019
Metabolic fingerprints of biofluids encode diverse diseases and particularly urine detection offers complete non-invasiveness for diagnostics of the future.
Jing Yang, Ran Wang, Lin-huan Huang, Mengji Zhang, Jingyang Niu, C. Bao, N. Shen, M. Dai, Qiang Guo, Qian Wang, Qin Wang, Qiong Fu, K. Qian   +12 more
semanticscholar   +1 more source

Targeting immune cell metabolism in kidney diseases

Nature Reviews Nephrology, 2021
P. Basso, Vinícius Andrade-Oliveira, N. Câmara   +2 more
semanticscholar   +1 more source

Onconephrology: The Intersections Between the Kidney and Cancer

Ca-A Cancer Journal for Clinicians, 2021
Mark A Perazella, Kenar D Jhaveri, Mitchell H Rosner   +2 more
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